Impact of ovarian endometrioma on oocytes and pregnancy outcome in in vitro fertilization

Suzuki, Takahiro; Izumi, Shun-ichiro; Matsubayashi, Hidehiko; Awaji, H.; Yoshikata, Kikuo; Makino, Tsunehisa

doi:10.1016/j.fertnstert.2004.11.028

Cited by 134 publications

(67 citation statements)

References 30 publications

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“…These morphological alterations were never observed in samples from contralateral healthy ovaries. This indicates that the ovarian pathological changes rather than the space-occupying lesion itself are responsible for the decline in ovarian reserve [13] and poor ovarian response in ART cycles [34,39]. Diminished ovarian reserve has been reported not only in patients suffering from ovarian endometriomas, but also in patients with minimal to mild disease.…”

Section: Reduced Ovarian Reserve In Patients Affected By Endometriosismentioning

confidence: 99%

“…Some authors suggest that IVF performance (oocytes quality, fertilization rates, embryo quality, and live birth rates) in the presence of endometriosis is impaired [18,34] while others show reserved outcomes [35,48]. Nevertheless, when good quality oocytes are fertilized, or when a large number of embryos is available, implantation rates seem to return to control values [49].…”

Section: Embryo/egg Freezingmentioning

confidence: 99%

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The role of fertility preservation in patients with endometriosis

Carrillo

Seidman

Cittadini

et al. 2016

J Assist Reprod Genet

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Patients affected with severe endometriosis are at significant risk for ovarian tissue damage, which may lead to infertility, reduced response to ovarian stimulation, and occasionally, premature ovarian failure. The risk for a compromised ovarian reserve in young patients is especially high following repeated surgical intervention and in the presence of bilateral endometriomas. In many cases, enhanced loss of ovarian reserve may also result from the damaging effect of the pathologic process on follicle reservoir even without surgical interventions. Women diagnosed with severe endometriosis and those designated for extensive ovarian surgical intervention are frequently not planning to conceive. In light of recent advances in fertility preservation techniques (FPT), such as oocytes and ovarian tissue freezing, as well as their increasing success rates, we critically evaluate the options for FPT in patients suffering from endometriosis. Personalized counseling should be offered to all patients with endometriosis taking into account age, extent of ovarian involvement, current ovarian reserve, previous and impending surgeries for endometriosis, along with current success rates and possible risks associated with FPT.

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Section: Reduced Ovarian Reserve In Patients Affected By Endometriosismentioning

confidence: 99%

Section: Embryo/egg Freezingmentioning

confidence: 99%

The role of fertility preservation in patients with endometriosis

Carrillo

Seidman

Cittadini

et al. 2016

J Assist Reprod Genet

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“…Daha önceki yapı-lan çalışmalarda endometriomanın bizatihi kendisinin over rezervi üzerine olan etkileri histopatolojik çalışmalarla ortaya konulmaya çalışılmıştır [8]. Bu çalışmalarda antral folikül sayısı [9], ovulasyon oranı veya gonodotropinlere yanıt incelenmiştir [10,11,12]. Geniş çaplı bir derlemede ovaryan endometriomaları bulunan hastalarda kontrol gurubuna göre ovulasyon indüksiyo-nu ile daha az folikül elde edildiği görülmüştür [13].…”

Section: Discussionunclassified

The Effect of the Ovarian Endometrioma Surgery on Ovarian Reserve and Ovarian Blood Flow

Yılmaz¹,

Uysal²,

Önoglu³

et al. 2015

Ann Clin Anal Med

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ÖzetAmaç: Laparaskopik endometriosis cerrahisinin ovaryan rezerv ve ovaryan kan akım parametreleri üzerine olan etkilerini araştırmak. Gereç ve Yöntem: Üçüncü basamak eğitim ve araştırma hastanesinde endometrioma nedeniyle laparaskopik cerrahi uygulanan 26 hasta prospektif olarak değerlendirildi. Olgulara cerrahi işlem öncesi ve sonrası adet periyodunun 3üncü günü FSH, LH ve E2 bakıldı. Operasyon öncesi ve sonrası olguların ultrasonografik olarak kist volümü, over volümü ve ovaryan arter rezistif indeks'i Doppler ultrasonografi ile değerlendirildi. Bulgular: Çalışma gurubundaki 26 hastanın yaş ortalaması 25,6 ± 4,5 (20-36 yaş) idi. Operasyon öncesi ve sonrası üçüncü gün bakılan hormonal değerler karşılaştırıldığında sırasıyla FSH (p: 0,455), LH (p: 0,672), değerlerinde bir değişiklik izlenmezken, E2 (p: 0,024) değerleri-nin anlamlı olarak azaldığı görüldü. Cerrahi sonrası ovaryan volüm anlamlı bir şekilde azalırken (p: 0,001), bu azalışın Ovaryan Arter RI değerlerini (p: 0,587) etkilemediği görüldü. Sonuç: Çalışmamızda ovaryan endometriomaların laparoskopik kistektomisi sonrasında over hacimlerinin anlamlı olarak azaldığını ama bunun, hormon sonuçlarına ve ovaryan arter kan akımlarına bakıldığında over rezervini etkilemediği görüldü. Anahtar KelimelerEndometriosis; Ovaryan Rezerv; Doppler Ultrasonografi Abstract Aim: To investigate the effectiveness of laparoscopic endometriosis surgery on ovarian reserve and ovarian blood flow index. Material and Method: Twenty-six patients were evaluated prospectively whom had laparoscopic surgery due to endometrioma in third care education and research hospital. Before and after surgical procedure all patients FSH, LH and E2 levels were measured in their 3rd menstrual period day. Periodically cysts and ovarian volume as well as ovarian artery resistive index measured by using transvaginal Doppler sonography. Results: Twenty-six patients' mean age was 25, 6 ± 4, 5 (20-36 years). When the compared to changes of preoperative and postoperative values of hormonal parameters FSH (p: 0,455) and LH (p: 0,672) were insignificant and E2 (p: 0,024) was significant respectively. While ovarian volume was decreasing significantly (p: 0,001), Ovarian Artery RI parameter was not changed (p: 0,587). Discussion: Our study was showed that while laparoscopic surgical treatment of ovarian endometriomas significantly decrease ovarian volume, but hormonal parameters and ovarian blood flow were not affected.

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“…Suzuki et al investigated the effect of endometriosis and the presence of an ovarian endometrioma on outcomes of IVF. Endometriosis affects the oocyte number but not the embryo quality or pregnancy outcome, irrespective of the presence of ovarian endometrioma (14). Somigliana et al reported that the presence of ovarian endometriomas is associated with a reduced responsiveness to gonadotropins.…”

Section: Tab 1 the Clinical Characteristics Of Groupsmentioning

confidence: 99%

“…The presence of endometrioma may be the most important predictor of a poor reproductive outcome (10 -12). Previous reports have suggested that ovarian endometriomas might produce substances that are toxic to oocytes (13) and impair the oocyte development (14).…”

mentioning

confidence: 99%

Does ovarian endometrioma affect the number of oocytes retrieved for in vitro fertilization?

Kıran¹,

Arıkan²,

Kaplanoğlu³

et al. 2012

BLL

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Abstract:Objective: To investigate the effects of ovarian endometrioma on the number of oocytes retrieved for in vitro fertilization (IVF). Background: The presence of endometrioma may be the most important predictor of a poor reproductive outcome. Literature data suggest that ovarian endometriomas might affect the response to ovarian stimulation and oocyte retrieval. Methods: The present retrospective study evaluates 2,023 women who applied to our center with an infertility complaint. Twenty-nine women with endometriomas (group 1) who were treated with IVF were included in the study. They were compared with 51 women with unexplained infertility (group 2) regarding the number of retrieved oocytes after egg retrieval and number of metaphase II oocytes. The diagnosis of endometrioma was made via ultrasound examination with the identifi cation of low-density cystic masses in the ovaries. The patients underwent a controlled ovarian hyperstimulation (COH) with either the long agonist mini-dose protocol or the multi-dose antagonist protocol. Results: The incidence of endometrioma in infertile women was found to be 1.4 %. The women's ages ranged between 24 and 45 years, and the duration of their infertility ranged between 12 and 216 months. The endometrioma was bilateral in 24 % of the cases. The mean endometrioma diameter was 26.2 ± 7.3 mm for the right ovary and 23.2±6.1 mm for the left ovary. The average number of retrieved oocytes after egg retrieval in groups 1 and 2 was 12.4±8.3 and 12.2 ± 8.6, respectively. The average number of metaphase II oocytes in groups 1 and 2 was 8.6±6.1 and 9.4 ± 7.3, respectively. The number of retrieved oocytes after egg retrieval and the number of metaphase II oocytes in both endometrioma group and unexplained infertile group were similar (p > 0.05). Conclusion: Endometrioma did not reduce the number of retrieved oocytes in a COH cycle for IVF treatment. However it should be noted that the ovarian response is affected by the size of endometriomas, bilaterality, previous surgeries, recurrence, and the patient's age (Tab. 1, Ref. 31). Full Text in PDF www.elis.sk.

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Impact of ovarian endometrioma on oocytes and pregnancy outcome in in vitro fertilization

Cited by 134 publications

References 30 publications

The role of fertility preservation in patients with endometriosis

The role of fertility preservation in patients with endometriosis

The Effect of the Ovarian Endometrioma Surgery on Ovarian Reserve and Ovarian Blood Flow

Does ovarian endometrioma affect the number of oocytes retrieved for in vitro fertilization?

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