Impact of PEGylated Nanoparticles on Tumor Targeted Drug Delivery

Mozar, Fitya Syarifa; Chowdhury, Ezharul Hoque

doi:10.2174/1381612824666180730161721

Cited by 56 publications

(25 citation statements)

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“…There are conflicting reports regarding the ideal surface charge required for nanoparticle‐assisted drug delivery . He et al (cancer treatment) revealed that particles with <15 mV surface charges exhibited ideal properties such as reduced macrophage uptake, longer circulation time and higher tumor retention . However, it is well established that the charge effect of cell‐uptake is cell type and surface charge dependent .…”

Section: Resultsmentioning

confidence: 99%

Synthesis and characterization of polylactide‐PAMAM “Janus‐type” linear‐dendritic hybrids

Chandrasiri

Abebe

Gupta

et al. 2019

J. Polym. Sci. Part A: Polym. Chem.

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Herein, we present a facile and comprehensive synthetic methodology for the preparation of polyester‐polyamidoamine (PAMAM) (i.e., polyester: polylactide [PLA] (hydrophobic) and polyamidoamine, PAMAM [hydrophilic]) polymers. A library of PLA‐PAMAM linear dendritic block copolymers (LDBCs) in which both l and d, l polylactide were employed in mass ratios of 30:70, 50:50, 70:30, and 90:10 (PLA:PAMAM) were synthesized and analyzed. When placed in aqueous media, the immiscibility of the hydrophilic and hydrophobic segments leads to nanophase‐segregation exhibited as the formation of aggregates (e.g., vesicles, worms, and/or micelles). By employing both stereochemical configurations of PLA, the differentiation in mass ratios of PLA‐PAMAM aided in elucidating the structure–property relationships of the LDBC system and provided a means toward the control of nanoparticle morphology. Transmission electron microscopy and dynamic light scattering afford the size and shape of the nanoparticles with diameters ranging from 10.6 for low mass ratios to 122.4 nm for high mass ratios of PLA‐PAMAM and positive zeta‐potential values between +24.7 mV and +48.2 mV. Furthermore, small‐angle X‐ray scattering (SAXS) studies were employed to obtain more detailed information on the morphological assemblies constructed via direct dissolution. Such insights provide a pathway toward nanomaterials with unique morphologies and tunable properties deemed relevant in the development of next generation biomaterials. © 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019, 57, 1448–1459

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Section: Resultsmentioning

confidence: 99%

Synthesis and characterization of polylactide‐PAMAM “Janus‐type” linear‐dendritic hybrids

Chandrasiri

Abebe

Gupta

et al. 2019

J. Polym. Sci. Part A: Polym. Chem.

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“…Moreover, it was confirmed by several studies that PEG having a MW of 2 kDa or higher is required to provide a useful steric hindrance on the surfaces of nanosystems in order to decrease protein adsorption and to reduce recognition by the MPS ( Bazile et al, 1995 ; Mosqueira et al, 1999 ; Fang, 2006 ; Owens and Peppas, 2006 ; Perrault and Chan, 2009 ). The PEG arrangement can also be modulated by the density of the PEG moieties on the particle surface, promoting a mushroom conformation at low polymer densities or a more extended brush state at higher densities ( Gulati et al, 2018 ; Mozar and Chowdhury, 2018 ).…”

Section: Drug Targetingmentioning

confidence: 99%

Biodegradable Polymeric Nanoparticles for Drug Delivery to Solid Tumors

et al. 2021

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Advances in nanotechnology have favored the development of novel colloidal formulations able to modulate the pharmacological and biopharmaceutical properties of drugs. The peculiar physico-chemical and technological properties of nanomaterial-based therapeutics have allowed for several successful applications in the treatment of cancer. The size, shape, charge and patterning of nanoscale therapeutic molecules are parameters that need to be investigated and modulated in order to promote and optimize cell and tissue interaction. In this review, the use of polymeric nanoparticles as drug delivery systems of anticancer compounds, their physico-chemical properties and their ability to be efficiently localized in specific tumor tissues have been described. The nanoencapsulation of antitumor active compounds in polymeric systems is a promising approach to improve the efficacy of various tumor treatments.

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“…A critical aspect of the study is to assess the surface charge of aggregates formed from the amphiphilic JDs. Generally, particles with positive surface charges below 15 mV display the ideal properties such as decreased macrophage uptake, [49] higher tumor retention, and longer circulation time [50] . In addition, the ideal surface charge depends on factors such as cell type, cellular uptake mechanism, and intracellular localization of nanoaggregates [5,51] .…”

Section: Resultsmentioning

confidence: 99%

“…Generally, particles with positive surface charges below 15 mV display the ideal properties such as decreased macrophage uptake, [49] higher tumor retention, and longer circulation time. [50] In addition, the ideal surface charge depends on factors such as cell type, cellular uptake mechanism, and intracellular localization of nanoaggregates. [5,51] There have been reported studies that explain the ability of cationic nanoaggregates to stay in a tumor for a prolonged time compared to anionic and neutral charged nanoaggregates.…”

Section: Surface Property Analysis Of Pamam -Fa Jds Based Nano Aggregmentioning

confidence: 99%

Structural and Surface Properties of Polyamidoamine (PAMAM) – Fatty Acid‐based Nanoaggregates Derived from Self‐assembling Janus Dendrimers

et al. 2020

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This study summarizes the synthesis, characterization, and evaluation of a library of biocompatible selfassembling Janus dendrimers (JDs) and their resulting nanostructures possessing either a cationic (NH 3 +), anionic (COO À), or neutral (OH) surface. Strategically designed for applications in therapeutic delivery, the dendrimers are comprised of a polyamidoamine (PAMAM) dendron as the hydrophilic portion and fatty acid (FA) functionalized dendrons as the hydrophobic portion. The physicochemical characterization and in vitro cell viability of amphiphilic JDs were performed. Microscopy (TEM) and dynamic light scattering (DLS) analysis indicate the size (i. e., diameters) of spherical nanoaggregates ranging from 40 to 100 nm with zeta-potential values ranging from À 17.9 to + 58.7 mV with respect to the terminal functional group of the JD employed. Furthermore, these systems exhibited spherical nanoaggregates with critical aggregate concentrations (CAC) ranging from 2.8 to 7.0 mg/L. At low concentrations (< 200 μg/mL), JDs nanoaggregates showed minimal cell growth inhibitory properties in the in vitro testing, demonstrating their safety. The results of this study prove that a simple yet strategic combination of chemically distinctive dendritic segments can afford a versatile library of unique JDs nanoplatforms with excellent potential for biomedical applications.

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Impact of PEGylated Nanoparticles on Tumor Targeted Drug Delivery

Cited by 56 publications

References 0 publications

Synthesis and characterization of polylactide‐PAMAM “Janus‐type” linear‐dendritic hybrids

Synthesis and characterization of polylactide‐PAMAM “Janus‐type” linear‐dendritic hybrids

Biodegradable Polymeric Nanoparticles for Drug Delivery to Solid Tumors

Structural and Surface Properties of Polyamidoamine (PAMAM) – Fatty Acid‐based Nanoaggregates Derived from Self‐assembling Janus Dendrimers

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