Impact of perfluorooctylethane on the formation of a semi-crystalline liquid-condensed phase in a phospholipid monolayer and of perfluorooctyl bromide on the adsorption of albumin on such a monolayer

Gerber, Frédéric; Vandamme, Thierry F.; Krafft, Marie Pierre

doi:10.1016/j.crci.2008.04.017

Cited by 6 publications

(19 citation statements)

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“…9-13 In particular, use of air saturated with fluorocarbon gases has recently been considered for RDS treatment. [35][36][37][38]65 This followed the observation that FC gases can prevent the formation of an LC phase in Langmuir monolayers of DPPC and can promote dissolution of existing LC domain. [35][36][37][38] A predominant symptom in RDS patients is a dyspnea arising from dysfunction and inactivation of PS.…”

Section: Discussionmentioning

confidence: 99%

“…[35][36][37][38]65 This followed the observation that FC gases can prevent the formation of an LC phase in Langmuir monolayers of DPPC and can promote dissolution of existing LC domain. [35][36][37][38] A predominant symptom in RDS patients is a dyspnea arising from dysfunction and inactivation of PS. Partial ventilation with air and fluorocarbon gases has been considered useful as RDS treatment.…”

Section: Discussionmentioning

confidence: 99%

“…Krafft and co-workers have recently examined the fluidization of DPPC monolayers utilizing fluorocarbon (FC) gases according to a novel technique in which the inspired air would be saturated by the FC. [35][36][37] It was found that the fluorocarbon gases effectively inhibit the formation of the semicrystalline (liquid-condensed) DPPC domains and facilitate the respreading of the DPPC monolayer. Moreover, gaseous PFOB promotes the respreading of a DPPC monolayer during compression and expansion on an albumin-supplemented subphase, 38 suggesting potential usefulness of such fluorocarbons in ARDS treatments.…”

Section: Introductionmentioning

confidence: 99%

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Fluorocarbon-Hybrid Pulmonary Surfactants for Replacement Therapy - A Langmuir Monolayer Study

et al. 2010

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Effective additives to pulmonary surfactant (PS) preparations for therapy of respiratory distress syndrome (RDS) are being intensively sought. We report here the investigation of the effects of partially fluorinated amphiphiles (PFA) on the surface behavior of a model PS formulation. When small amounts of a partially fluorinated alcohol C(8)F(17)C(m)H(2m)OH (F8HmOH, m = 5 and 11) are added to the PS model preparation (a dipalmitoylphosphatidylcholine (DPPC)/Hel 13-5 peptide mixture) considered here, the effectiveness of the latter in in vitro pulmonary functions is enhanced. The mechanism for the improved efficacy depends on the hydrophobic chain length of the added PFA molecules. The shorter PFA, F8H5OH, when incorporated in the monolayer of the PS model preparation, promotes a disordered liquid-expanded (LE) phase upon lateral compression (fluidization). In contrast, the addition of the longer PFA, F8H11OH, reduces the disordered LE/ordered liquid-condensed (LC) phase transition pressure and promotes the growth of ordered domains (solidification). Furthermore, compression-expansion cycles suggest that F8H5OH, when incorporated in the PS model preparation, undergoes an irreversible elimination into the subphase, whereas F8H11OH enhances the squeeze-out phenomenon of the SP-B mimicking peptide, which is important in pulmonary functions and is related to the formation of a solid-like monolayer at the surface and of a surface reservoir just below the surface. F8H11OH particularly reinforces the effectiveness of DPPC in terms of minimum reachable surface tension, and of preservation of the integrated hysteresis area between compression and expansion isotherms, the two latter parameters being generally accepted indices for assessing PS efficacy. We suggest that PFA amphiphiles may be useful potential additives for synthetic PS preparations destined for treatment of RDS in premature infants and in adults.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Fluorocarbon-Hybrid Pulmonary Surfactants for Replacement Therapy - A Langmuir Monolayer Study

et al. 2010

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“…They tend to self-assemble more easily and form better organized and more stable systems than their hydrocarbon counterparts. Owing to these properties, fluorocarbons and fluorinated surfactants have the potential as being used in many applications including the drug delivery, gene transfection, intravascular oxygen transport and other biomedical field [22][23][24][25][26]. In these applications, it is also critical to know the toxicity of the molecules that are utilized.…”

Section: Introductionmentioning

confidence: 98%

“…Moreover, they are lipophobic [22,23]. They can fluidize the lipid monolayer and this property of fluorocarbons can be used to capture the fluid like behavior of lung surfactants [24,25]. Fluorinated surfactants have the tendency to reduce the surface tension to very low value.…”

Section: Introductionmentioning

confidence: 99%

Biophysical investigation of the interfacial properties of cationic fluorocarbon/hydrocarbon hybrid surfactant: Mimicking the lung surfactant protein C

Aydoğan

Uslu

Tanacı

2011

Journal of Colloid and Interface Science

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Synthesis and Manipulation of Colloid and Interface Structure and Properties by Exposure to Perfluorocarbon Gases

Krafft

2022

PATAI'S Chemistry of Functional Groups

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This chapter exposes the notion of physical reactivity of chemically inert nonfunctional compounds and the decisive role it can play in the synthesis of colloids and interfaces and in controlling their properties. Thus, introduction of perfluorocarbon vapor in the atmosphere above an aqueous dispersion of phospholipids promotes the adsorption of the latter to the air/water interface. When contacted with a monolayer of dipalmitoylphosphatidylcholine, perfluorocarbons fluidize this monolayer, inhibiting the formation of the ordered semicrystalline phase upon compression. Perfluorohexane can help desorb serum albumin from a phospholipid film, allowing the phospholipid to respread upon expansion. The perfluorocarbon also effectively counteracts lung surfactant deactivation by serum proteins. Exposure to perfluorohexane gas of a monolayer of phospholipids spread on aqueous solutions of C 2 F 5 ‐labeled molecules prompts their selective adsorption into the interfacial film. When the phospholipid forms liquid‐condensed monolayers, the C 2 F 5 ‐labeled species remain partially trapped in the monolayer after the perfluorohexane is removed. Perfluorocarbons can also impact the behavior of nanoparticles. Thus, nanodiamond clusters are efficiently disaggregated, which promotes their adsorption to the air/water interface, thereby enabling the formation of perfluorocarbon‐stabilized, nanodiamond‐shelled microbubbles. Prospective applications include lung surfactant substitutes that resist deactivation by serum proteins for treating lung conditions, novel drug‐loaded medical microbubbles, and nanodiamond‐based microbubbles for multimodal diagnostic and delivery purposes.

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Impact of perfluorooctylethane on the formation of a semi-crystalline liquid-condensed phase in a phospholipid monolayer and of perfluorooctyl bromide on the adsorption of albumin on such a monolayer

Abstract: a Syste `mes organise ´s fluore ´s a `finalite ´s the ´rapeutiques (SOFFT),

Cited by 6 publications

References 57 publications

Fluorocarbon-Hybrid Pulmonary Surfactants for Replacement Therapy - A Langmuir Monolayer Study

Fluorocarbon-Hybrid Pulmonary Surfactants for Replacement Therapy - A Langmuir Monolayer Study

Biophysical investigation of the interfacial properties of cationic fluorocarbon/hydrocarbon hybrid surfactant: Mimicking the lung surfactant protein C

Synthesis and Manipulation of Colloid and Interface Structure and Properties by Exposure to Perfluorocarbon Gases

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