Impact of perioperative red blood cell transfusion on postoperative recovery and long-term outcome in patients undergoing surgery for ovarian cancer: A propensity score-matched analysis

Zhang, Hao; Wu, Xin; Xu, Zheng; Sun, Zhirong; Zhu, Minmin; Chen, Wankun; Miao, Changhong

doi:10.1016/j.ygyno.2019.12.006

Cited by 22 publications

(24 citation statements)

References 43 publications

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“…Additionally, rates of organ-space SSI, which are an imperfect marker and likely underestimate the incidence of anastomotic leak after bowel resection ( Rickles et al, 2013 ), were low overall, but were twice as likely to occur among patients who had bowel resection (1% vs 5%, p = 0.12). Recent studies have examined the impact of allogeneic red blood cell transfusion on recurrence and survival among patients undergoing surgery for ovarian cancer, with overall mixed results ( Zhang et al, 2020 , Hunsicker et al, 2019 , Pergialiotis et al, 2020 ). Given that our bowel resection cohort was much more likely to receive a blood transfusion (p < 0.01), consideration of this impact is warranted if transfusion of blood products is ultimately determined to be an independent predictor of worse recurrence and survival.…”

Section: Discussionmentioning

confidence: 99%

Survival impact of bowel resection at the time of interval cytoreductive surgery for advanced ovarian cancer

McNamara

Guerra

Qin

et al. 2021

Gynecologic Oncology Reports

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Highlights Bowel resection is associated with decreased three-year survival. Bowel resection does not impact progression free survival. Bowel resection is associated with significant peri -operative complication. Sequelae of peri -operative morbidity may contribute to decreased survival. Bowel resection may be a surrogate for worse tumor molecular subtype.

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Section: Discussionmentioning

confidence: 99%

Survival impact of bowel resection at the time of interval cytoreductive surgery for advanced ovarian cancer

McNamara

Guerra

Qin

et al. 2021

Gynecologic Oncology Reports

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“…In the present study, the incidence of postoperative complications in patients receiving blood transfusion increased signi cantly during the perioperative period. Zhang et al reported that a perioperative blood transfusion potentially increases the risk of postoperative complications and is associated with a prolonged LOS (9). Furthermore, another study reported that perioperative blood transfusion may be associated with worse outcome in patients undergoing surgery(16).…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, some studies have found that the infusion of allogeneic blood inhibits the immune function of patients, which is not conducive to improving the prognosis in the perioperative period (9).…”

Section: Introductionmentioning

confidence: 99%

Effects of perioperative red blood cell transfusion on systemic immune indicators and postoperative recovery in patients undergoing cesarean section: A propensity score matching analysis

Zhou

Tao

et al. 2021

Preprint

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Background Postpartum hemorrhage (PPH) is one of the leading causes of maternal death in all regions of the world. Intra-operative red blood cell transfusion is one of the most effective strategies to treat PPH. However, the effect of blood transfusion on patients undergoing cesarean section remains unclear. The aim of this study was to investigate the effects of a intra-operative blood transfusion on systemic immune indicators and postoperative recovery in patients undergoing cesarean section. Methods This retrospective study enrolled patients undergoing cesarean section between January 2016 and June 2020. We divided these patients into two groups according to whether they received a intraoperative blood transfusion. Baseline characteristics were compared between groups. After propensity score matching, the length of stay (LOS), perioperative systemic inflammation-based scores, and postoperative complications were compared. Univariate and multivariable Cox proportional hazard models were used to evaluate the associations between covariates and outcomes. Results A total of 1221 patients were enrolled. After propensity score matching, a significant difference in LOS was observed between groups (4.2days vs. 6.6days, P=0.026). The postoperative complication rate in the blood transfusion (BT) group was significantly higher than that in the non-blood transfusion(NBT) group (vomiting, 3.2% vs. 4.9%, P=0.032; fever, 5.41% vs. 2.24%, P=0.032; wound complications, 15.44% vs. 10.45%, P=0.028; intestinal obstructions, 5.88% vs. 2.75%, P=0.034, respectively). The systemic inflammatory indicators fluctuated significantly in the BT group compared with the NBT group on POD1 and POD3. The multivariate analysis indicated that intra-operative blood transfusion was associated with a longer LOS (hazard ratio: 1.52, 95% confidence interval: 1.07, 2.25). Conclusions A intra-operative blood transfusion was associated with fluctuations in systemic inflammatory indicators, higher postoperative complication rates and a prolonged length of stay.

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“…patients have an increased risk of developing infectious and non-infectious postoperative complications after major cancer surgery. [8][9][10] However, the results from a recent randomised controlled trial (RCT) demonstrate that a restrictive approach in which transfusions were triggered by haemoglobin (Hb) lower than 7 g/dL increased the risk of postoperative complications when compared with a liberal approach (Hb <9 g/dL). 11 Perioperative blood product transfusions may also impact long-term cancer outcomes (ie, recurrence and survival) by modulating the immune system, promoting inflammation and directly affecting cancer cells.…”

Section: Open Accessmentioning

confidence: 99%

International multicentre observational study to evaluate the association between perioperative red blood cell transfusions and 1-year mortality after major cancer surgery (ARCA-1): study design, statistical analysis plan and study protocol

et al. 2021

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IntroductionBlood transfusion is still common in patients undergoing major cancer surgery. Blood transfusion can be associated with poor prognosis in patients with cancer. Perioperative Care in the Cancer Patient -1 (ARCA-1) aims to assess in a large cohort of patients the current incidence, pattern of practice and associations between perioperative blood transfusions and 1-year survival in patients undergoing major cancer surgery.Methods and analysisARCA-1 is a prospective international multicentre observational study that will include adult patients scheduled to have major cancer surgical procedures with the intention to cure, and an overnight planned hospital admission. The study will be opened for 1 year for enrolment (7 January 2020–7 February 2021). Each centre will enrol patients for 30 days. The primary endpoint of this study is all-cause mortality 1 year after major cancer surgery. Secondary endpoints are rate of perioperative blood product use, cancer-specific mortality at 1 year and PFSs and 30-day morbidity and mortality.Ethics and disseminationThis study was approved by the Institutional Review Board at The University of Texas—MD Anderson Cancer Center. The study results will be published in peer-reviewed journals and disseminated at international conferences.Trial registration numberNCT04491409.

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Impact of perioperative red blood cell transfusion on postoperative recovery and long-term outcome in patients undergoing surgery for ovarian cancer: A propensity score-matched analysis

Cited by 22 publications

References 43 publications

Survival impact of bowel resection at the time of interval cytoreductive surgery for advanced ovarian cancer

Survival impact of bowel resection at the time of interval cytoreductive surgery for advanced ovarian cancer

Effects of perioperative red blood cell transfusion on systemic immune indicators and postoperative recovery in patients undergoing cesarean section: A propensity score matching analysis

International multicentre observational study to evaluate the association between perioperative red blood cell transfusions and 1-year mortality after major cancer surgery (ARCA-1): study design, statistical analysis plan and study protocol

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