Impact of Photobiomodulation and Condition Medium on Mast Cell Counts, Degranulation, and Wound Strength in Infected Skin Wound Healing of Diabetic Rats

Kouhkheil, Reza; Fridoni, Mohammadjavad; Abdollhifar, Mohammad‐Amin; Amini, Abdollah; Bayat, Sahar; Ghoreishi, Seyed Kamran; Chien, Sufan; Kazemi, Mahsa; Bayat, Mohammad

doi:10.1089/photob.2019.4691

Cited by 23 publications

(19 citation statements)

References 54 publications

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“…Finally, photoimmodulation, or photoimmodulation combined with condition medium derived from human bone marrow MSCs, significantly decreases both the total numbers of MCs and their degranulation and improves wound healing in diabetes [96]. Omega-3 fatty acids significantly decreased the diabetic wound area by affecting the concentration of MCs [97].…”

Section: Mcs Stabilizersmentioning

confidence: 99%

Mast Cells in Diabetes and Diabetic Wound Healing

et al. 2020

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Mast cells (MCs) are granulated, immune cells of the myeloid lineage that are present in connective tissues. Apart from their classical role in allergies, MCs also mediate various inflammatory responses due to the nature of their secretory products. They are involved in important physiological and pathophysiological responses related to inflammation, chronic wounds, and autoimmune diseases. There are also indications that MCs are associated with diabetes and its complications. MCs and MC-derived mediators participate in all wound healing stages and are involved in the pathogenesis of non-healing, chronic diabetic foot ulcers (DFUs). More specifically, recent work has shown increased degranulation of skin MCs in human diabetes and diabetic mice, which is associated with impaired wound healing. Furthermore, MC stabilization, either systemic or local at the skin level, improves wound healing in diabetic mice. Understanding the precise role of MCs in wound progression and healing processes can be of critical importance as it can lead to the development of new targeted therapies for diabetic foot ulceration, one of the most devastating complications of diabetes.

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Section: Mcs Stabilizersmentioning

confidence: 99%

Mast Cells in Diabetes and Diabetic Wound Healing

et al. 2020

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“…Accordingly, since tryptase contributes to the pathogenesis of diabetes and its complexities, aiming MCs as a new remedy for diabetes needs more investigations [12]. In this context, it has been reported that the increased numbers of total MC density and degranulation in diabetic animals negatively affected the potentiometric properties of their skin wounds [13][14][15]. Recently, Wygrecka et al have suggested that MCs might provide to the fibrotic course by encouraging local fibroblasts in the lung, therefore leading to the pathogenesis of the illness [16].…”

Section: Discussionmentioning

confidence: 99%

Aerobic Exercise‐Assisted Cardiac Regeneration by Inhibiting Tryptase Release in Mast Cells after Myocardial Infarction

Bayat

Chien

Chehelcheraghi

2021

BioMed Research International

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Background. Cardiovascular disease (CVD) contributes critically to the mortality, morbidity, and economic problem of illness globally. Exercise is a share of everyone’s life. Some evidence-based studies have frequently shown a progressive correlation between physical activity and good health. Objective. The effects of daily exercise on cardiomyocyte size, collagen content (fibrosis), and releasing mast cells (MCsʼ) tryptase of the model of myocardial infarction (MI) were assessed. Methods. 40 rats were coincidentally spread into sham+inertia (control), sham+exercise, infarction+inertia, and infarction+exercise groups. An experimental model of acute MI was induced in infarction groups. One week after surgery, exercising groups were allowed to an aerobic exercise program for six weeks. At the endpoint of the study, all examinations were performed. Results. We found lesser fibrosis in sham+exercise and infarction+exercise groups compared to sham+inertia and infarction+inertia groups, respectively ( p = 0.023 , p = 0.001 ). Also, infarction groups were significantly lower than sham groups ( p < 0.05 ) and the infarction+exercise group was significantly lower than the infarction+inertia group ( p < 0.05 ). The effect of exercise on MCs while increased MC density and degranulation occur at the site of fibrosis, we demonstrated that exercise decreases both total MC density and degranulation in both sham and infarction groups ( p < 0.05 ). Immunohistochemistry examinations were significantly higher expression of MCsʼ tryptase in infarction groups than sham groups ( p < 0.05 , p < 0.0001 ). Conclusion. Exercise improves fibrosis and cardiac function in both healthy and MI rats by inhibiting released MCsʼ tryptase.

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“…Moreover, 72 mice infected with methicillin-resistant Staphylococcus aureus were treated with MSC-CM or MSC-CM plus photobiomodulation (PBM). MSC-CM plus PBM decreased colony-forming units and the number of inflammatory cells (Fridoni et al, 2019;Kouhkheil et al, 2019).…”

Section: Other Woundsmentioning

confidence: 95%

“…MSC-CM was also evaluated in second-and third-degree burn wounds (Aryan et al, 2019;Li J. Y. et al, 2019;Zhou et al, 2019), radiation-induced wounds (Sun et al, 2019), and infected wounds (Fridoni et al, 2019;Kouhkheil et al, 2019; Table 3). Cells were isolated from human tissues: bone marrow (Aryan et al, 2019;Fridoni et al, 2019;Kouhkheil et al, 2019), umbilical cord (Zhou et al, 2019), Wharton's jelly (Sun et al, 2019), and placenta (Li J. Y. et al, 2019). MSCs from passages 3 to 8 at 60-80% confluence were used.…”

Section: Other Woundsmentioning

confidence: 99%

Mesenchymal Stromal Cell-Conditioned Medium for Skin Diseases: A Systematic Review

Montero‐Vílchez

Sierra-Sánchez

Sánchez‐Díaz

et al. 2021

Front. Cell Dev. Biol.

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The skin is the largest organ of the human body, and its dysfunction is related to many diseases. There is a need to find new potential effective therapies for some skin conditions such as inflammatory diseases, wound healing, or hair restoration. Mesenchymal stromal cell (MSC)-conditioned medium (CM) provides a potential opportunity in the treatment of skin disease. Thus, the objective of this review is to evaluate the uses of MSC-CM for treating skin diseases in both animal and human models. A systematic review was conducted regarding the use of MSC-CM for treating skin conditions. One hundred one studies were analyzed. MSC-CM was evaluated in wound healing (55), hypertrophic scars (9), flap reperfusion (4), hair restoration (15), skin rejuvenation (15), and inflammatory skin diseases (3). MSC-CM was obtained from different MSC sources, mainly adipose tissue, bone marrow, and umbilical cord blood. MSC-CM was tested intravenously, intraperitoneally, subcutaneously, intradermally or intralesionally injected or topically applied. MSC-CM was used in both animals and humans. MSC-CM improved wound healing, hair restoration, skin rejuvenation, atopic dermatitis, and psoriasis in both animals and humans. MSC-CM also decreased hypertrophic scars and flap ischemia in animal models. In conclusion, MSC-CM is a promising therapy for skin conditions. Further studies are needed to corroborate safety and effectiveness and to standardize CM manufacturing.

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Impact of Photobiomodulation and Condition Medium on Mast Cell Counts, Degranulation, and Wound Strength in Infected Skin Wound Healing of Diabetic Rats

Cited by 23 publications

References 54 publications

Mast Cells in Diabetes and Diabetic Wound Healing

Mast Cells in Diabetes and Diabetic Wound Healing

Aerobic Exercise‐Assisted Cardiac Regeneration by Inhibiting Tryptase Release in Mast Cells after Myocardial Infarction

Mesenchymal Stromal Cell-Conditioned Medium for Skin Diseases: A Systematic Review

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