Impact of photobiomodulation on macrophages and their polarization during diabetic wound healing: a systematic review

Rahmannia, Maryam; Amini, Abdollah; Chien, Sufan; Bayat, Mohammad

doi:10.1007/s10103-022-03581-5

Cited by 11 publications

(5 citation statements)

References 68 publications

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“…Post-transcriptional control is also an important regulator of macrophage polarization in diabetes. For example, microRNAs have been shown to be important regulators of gene expression during macrophage polarization [9]. MicroRNAs (miRNAs) are non-coding small RNAs about 20 base pairs in length.…”

Section: Alterations In Macrophage Polarization In Diabetic Woundsmentioning

confidence: 99%

“…During the study of the mechanisms underlying diabetes-related impaired wound healing, accumulating evidence suggests that macrophages play a pivotal role in orchestrating proper wound healing [9]. In the early stages of normal wound healing, macrophages polarize to an M1-like phenotype, whereby they remove pathogens, dead cells and debris, and promote inflammation through secreting pro-inflammatory cytokines [10].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Macrophages as a Target for Treating Diabetic Foot Ulcers

Zhu¹,

Xiao²,

Jiang³

et al. 2023

Diabetic Foot - Recent Advances

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In all stages of wound healing, macrophages play a pivotal role by coordinating the repair steps in a timely and accurate fashion. The successful completion of wound healing requires proper spatiotemporal presence and function of macrophages. Diabetes significantly alters the proliferation, polarization and functionality of macrophages, leading to a suboptimal but prolonged pro-inflammatory M1-like phenotype in wound macrophages and a failure of their late transition to a reparative M2-like phenotype. This defect in macrophage phenotype and the proper transition results in delayed or even failure of wound healing. Specifically in the diabetic foot ulcer (DFUs), this macrophage dysfunction results in chronic infection and potentially amputation. The abnormal macrophage phenotype in diabetes is not fully understood but is believed to mainly result from epigenetic changes in macrophages and altered interactions between macrophages and other cell types, such as fibroblasts, endothelial cells, neutrophils and T-cells. Recent research on DFUs has focused on developing strategies to improve diabetic wound repair through modulation of macrophage polarization. Treatment of DFUs will greatly benefit from a multi-modal therapy that includes controlling high blood glucose, topical support, prevention of secondary infection, resolution of sustained inflammation and application of cellular therapies targeting macrophages.

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Section: Alterations In Macrophage Polarization In Diabetic Woundsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Macrophages as a Target for Treating Diabetic Foot Ulcers

Zhu¹,

Xiao²,

Jiang³

et al. 2023

Diabetic Foot - Recent Advances

View full text Add to dashboard Cite

show abstract

“…Low-power lasers have been widely used for the treatment of various conditions because they can induce the photobiomodulation effect in biological tissues. Therapeutic protocols based on photobiomodulation are available and used successfully for reducing/accelerating inflammatory processes [2,3], reducing pain [4,5], promoting wound healing [6,7], and treating muscle and nerve injuries [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Low-power infrared laser on survival, proliferation, and reactive oxygen species levels in Escherichia coli cultures

da Cunha Sales,

de Pontes dos Santos,

da Silva Ferreira

et al. 2024

Laser Phys.

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Laser devices are light sources that emit monochromatic, coherent, and collimated electromagnetic radiation beams. Low-power lasers are widely used to treat clinical conditions based on the photobiomodulation effect. Despite therapeutic applications, mainly in continuous waves, limited data are available on photobiomodulation effects induced by low-power lasers in the pulsed emission mode. Thus, the aim of this study was to evaluate the effects of a low-power pulsed infrared laser on survival, proliferation, DNA damage, and reactive oxygen species (ROS) levels in Escherichia coli cells. E. coli C600 cultures and pUC19 plasmids were exposed to a low-power pulsed (5000 Hz) infrared (904 nm) laser (1.1, 2.3, and 4.6 J). Bacterial survival was evaluated by survival fractions, bacterial proliferation was evaluated by measurement of bacterial colony areas, DNA damage was evaluated by plasmid profiling in agarose gels after electrophoresis, and ROS level was evaluated by flow cytometry. The results suggest that exposure to a low-power infrared laser in pulsed emission mode does not alter the proliferation of E. coli C600 and the electrophoretic profile of bacterial plasmids but decreases survival and increases ROS levels in E. coli C600 cultures.

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“…Recently, the term photobiomodulation (PBM) has replaced the previous low-level laser therapy due to it improperly representing electricity and total energy utilization. PBM acts as a form of light therapy by using nonionized light sources to initiate a non-thermal effect in which endogenous chromoplasts result in photo-physicochemical cascades at varying biological levels [ 15 , 16 ]. Intravascular PBM (iPBM) has been advocated since the 1960s; this non-drug therapy was first applied for the treatment of cardiovascular disease and is believed to improve blood circulation and blood cell function [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Intravascular Photobiomodulation on Insomnia, Muscle Soreness, and Biochemistry Profiles: An Eight-Year Retrospective Cohort

et al. 2023

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Background: Although cognitive-behavioral therapy is the first-line treatment for insomnia, pharmacotherapy is often prescribed to treat insomnia and related symptoms. In addition, muscle relaxants are commonly prescribed to alleviate muscle soreness when the pain is unbearable. However, pharmacotherapy can lead to numerous side effects. The non-drug strategy intravascular laser irradiation of blood (iPBM) has been advocated to improve pain, wound healing, blood circulation, and blood cell function to relieve insomnia and muscle soreness symptoms. Therefore, we assessed whether iPBM improves blood parameters and compared drug use before and after iPBM therapy. Methods: Consecutive patients who received iPBM therapy between January 2013 and August 2021 were reviewed. The associations between laboratory data, pharmacotherapies, and iPBM therapy were retrospectively analyzed. We compared patient characteristics, blood parameters, and drug use within the three months before the first treatment and the three months after the last treatment. We also compared the changes before and after treatment in patients who received ≥10 or 1–9 iPBM treatments. Result: We assessed 183 eligible patients who received iPBM treatment. Of them, 18 patients reported insomnia disturbance, and 128 patients reported pain in any part of their body. After the treatment, HGB and HCT significantly increased after treatment in both the ≥10 and 1–9 iPBM treatment groups (HGB p < 0.001 and p = 0.046; HCT p < 0.001 and p = 0.029, respectively). Pharmacotherapy analysis revealed no significant differences in drug use before and after treatment, though drug use tended to decrease after iPBM. Conclusions: iPBM therapy is an efficient, beneficial, and feasible treatment that increases HGB and HCT. While the results of this study do not support the suggestion that iPBM reduces drug use, further larger studies using symptom scales are needed to confirm the changes in insomnia and muscle soreness after iPBM treatment.

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Impact of photobiomodulation on macrophages and their polarization during diabetic wound healing: a systematic review

Cited by 11 publications

References 68 publications

Macrophages as a Target for Treating Diabetic Foot Ulcers

Macrophages as a Target for Treating Diabetic Foot Ulcers

Low-power infrared laser on survival, proliferation, and reactive oxygen species levels in Escherichia coli cultures

Effects of Intravascular Photobiomodulation on Insomnia, Muscle Soreness, and Biochemistry Profiles: An Eight-Year Retrospective Cohort

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