Impact of polysubstance use on social and non-affective cognitive performance among treatment-seeking individuals with alcohol use disorders

Lewis, Ben; Garcia, Christian; Bohan, Riley; Nixon, Sara Jo

doi:10.1016/j.addbeh.2020.106359

Cited by 10 publications

(7 citation statements)

References 46 publications

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“…The mean age of the HC was 43.3 (SD=12.5), and the mean age of individuals with AUD was 40.4 (SD=8.9). As previously reported in the treatmentseeking population (Lewis et al, 2019;Lewis et al, 2020;Hoffman, Lewis, & Nixon, 2019), the groups significantly differed on typical alcohol consumption, binge alcohol consumption, BDI, AI and smoking habits (all p's<.05). There were no significant differences between men and women within each group.…”

Section: Demographicssupporting

confidence: 81%

Posterior Alpha Power During Working Memory Maintenance in Alcohol Use Disorder

Rilo

2020

UFJUR

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Individuals with alcohol use disorder (AUD) display modest neurobehavioral deficits on cognitive tasks such as working memory (WM). Neurophysiology (i.e. posterior alpha power) during the maintenance phase of a WM task was compared. Healthy controls (HC, n=50) and newly abstinent individuals with AUD (n=42) completed a directed attend/ignore WM task. Spectral alpha power was extracted from the posterior portion of the scalp. A mixed linear model compared posterior alpha power controlling for alpha power in a baseline condition between group (HC vs. AUD) and sex (male vs. female). Main effects for group (p=.01) and sex (p=.003) were significant. HC displayed a higher alpha power compared to that of individuals with AUD. Males also presented with higher alpha power compared to women. There was no significant interaction between group and sex. An exploratory analysis to determine a relationship between alpha power and performance on the task was conducted and a differential relationship between groups (p<.001) was found. There was no significant relationship between performance and spectral power for HC, but a negative relationship was found for individuals with AUD. Higher alpha power was associated with decreased accuracy (p=.09). Individuals with AUD display a lower alpha power compared to HC, and this is associated with increased accuracy. Whether this signifies a compensatory mechanism remains a question intended for investigation.

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Section: Demographicssupporting

confidence: 81%

Posterior Alpha Power During Working Memory Maintenance in Alcohol Use Disorder

Rilo

2020

UFJUR

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“…These assumptions were confirmed and are in-line with some previous research that studied selected aspects of language, communication, and social cognition [ 27 , 40 ]. In previous studies, affective prosody impairments and difficulties in emotional decoding have been quite extensively researched in patients with AUD [ 28 , 32 , 33 , 55 ]. Monnot et al [ 56 ] suggested that, as a result of changes in the brain, people with AUD have greater difficulty understanding the emotional valence of speech, which can impact personal relationships in different situations as well as the effectiveness of therapeutic interventions.…”

Section: Discussionmentioning

confidence: 99%

Higher-Order Language Dysfunctions in Individuals with Alcohol Use Disorder

Karabanowicz

Tyburski

Karasiewicz

et al. 2021

JCM

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Patients with alcohol use disorders (AUD) have difficulties with certain aspects of higher-order language functions (HOLF) but there is no data on a wide range of these functions in this group. Therefore, the aim of this study was to compare different aspects of HOLF in patients with AUD and healthy controls (HC). A total of 31 patients with AUD and 44 HC took part in the study. We assessed HOLF with the Right Hemisphere Language Battery (RHLB) and measured control variables: depression using the Patient Health Questionnaire (PHQ) as well as the speed of processing and executive functions with the Color Trails Test (CTT). Patients with AUD had lower results on nine RHLB tests. Moreover, AUD patients had higher scores on PHQ and longer reaction times on CTT. The differences in most RHLB results remained significant after co-varying the control variables. Patients with AUD have difficulties with making inferences from the text, understanding the meaning of individual words, metaphorical content, and prosody, which may impede the comprehension and production of discourse in which linguistic elements must be integrated with non-verbal cues and contextual information. These disturbances may impact various spheres of everyday life and negatively influence social, private, and professional functioning.

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“…One explanation for these apparent inconsistencies in findings on facial emotion processing in individuals with AUD could be heterogeneity of the disorder itself (Litten et al, 2015). For example, one study found that women with AUD, but not men, had facial emotion processing deficits (Lewis et al, 2019), and that emotion processing deficits were more severe in individuals with AUD and polysubstance use (Lewis et al, 2020). Another found that only in combination with individual differences in anxiety and sensation seeking did alcohol‐related effects on neural emotion processing prospectively predict AUD (Shakra et al, 2018).…”

Section: Alcohol Use Disorder and Anxietymentioning

confidence: 99%

A Distinct Neurophenotype of Fearful Face Processing in Alcohol Use Disorder With and Without Comorbid Anxiety

MacIlvane

Fede

Pearson

et al. 2020

Alcoholism Clin & Exp Res

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Background: Individuals with alcohol use disorder (AUD) can present with comorbid anxiety symptoms and often have deficits in emotional processing. Previous research suggests brain response is altered during facial affect recognition tasks, especially in limbic areas, due to either AUD or anxiety symptomology; however, the impact of both AUD and clinically significant anxiety symptoms during these tasks has not yet been examined. Methods: In this study, we investigated neural activation differences during an emotional facematching task. Participants (N = 232) underwent fMRI scanning, as part of a larger study. Three groups were investigated: individuals with diagnosed AUD and elevated anxiety traits (AUD + ANX, n = 90), individuals with diagnosed AUD but non-clinically significant levels of anxiety (AUD-ANX, n = 39), and healthy controls (HC, n = 103). Results: Our results illustrate distinct neurophenotypes of AUD, where individuals with comorbid anxiety symptomology have blunted emotional face processing while those with singular AUD are hyperresponsive. Conclusions: This suggests AUD with anxiety symptomology may have a unique neurobiological underpinning, and treatment and intervention should be tailored to individual constellations of symptoms.

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Impact of polysubstance use on social and non-affective cognitive performance among treatment-seeking individuals with alcohol use disorders

Cited by 10 publications

References 46 publications

Posterior Alpha Power During Working Memory Maintenance in Alcohol Use Disorder

Posterior Alpha Power During Working Memory Maintenance in Alcohol Use Disorder

Higher-Order Language Dysfunctions in Individuals with Alcohol Use Disorder

A Distinct Neurophenotype of Fearful Face Processing in Alcohol Use Disorder With and Without Comorbid Anxiety

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