Impact of pre-radiation therapy quality of life in lung cancer survival: a prospective, intention-to-treat, multicenter study

Gomez, Juan Povedano; Vega, Gabriela; Cacicedo, Jon; León, B.D. Delgado; Rivera, Daniel; Fernández, J; Campo, Eleonor Rivin del; Gordillo, María Dolores Gordillo; Guerra, José Luis López

doi:10.1007/s12094-020-02310-0

Cited by 9 publications

(12 citation statements)

References 25 publications

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“…The QoL scale of the EORTC was scored from 0 to 100, where higher scores in general state and functional scales represent a higher functional level, while in the symptoms scale, the higher the score, the greater symptomatology. [ 20 ]…”

Section: Methodsmentioning

confidence: 99%

Associated factors with constipation and health-related quality of life in lung cancer patients with platinum-based chemotherapy

Chen

Zhang

et al. 2021

Medicine

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The main purpose of this study was to investigate current state of constipation for lung cancer (LC) patients receiving platinum-based chemotherapy. The relationships between social demography, clinical variables, psychological status, and constipation were analyzed. In addition, quality of life (QoL) in LC patients with constipation was also analyzed. One hundred LC patients participated in this cross-sectional study. Under the guidance of the researchers, Functional Living Index-Emesis, Piper Fatigue Scale, Patient Health Questionnaire, Generalized Anxiety Disorder-7, European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 (version 3.0), Pittsburgh Sleep Quality Index, General Well-being Scale, Social Support Rate Scale, General Self-Efficacy Scale, and other related questionnaires were completed. The result showed the symptom of constipation was observed in 41 (41%) LC patients. The occurrence and development of constipation were associated with gender, food intake, exercise, nausea, fatigue, anxiety, depression, sleep disorders, and happiness. The study also found patients with constipation had significant lower QoL scores, especially the score in the general state. Constipation was very common in LC patients undergoing platinum-based chemotherapy. Reduced food intake and fatigue were the independent factors. Constipation significantly affects the QoL of the patients. Therefore, more attention should be paid to the risk factors of constipation in LC patients undergoing platinum-based chemotherapy, the earlier intervention was done to these patients, the better to improve their QoL.

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Section: Methodsmentioning

confidence: 99%

Associated factors with constipation and health-related quality of life in lung cancer patients with platinum-based chemotherapy

Chen

Zhang

et al. 2021

Medicine

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“…Generally speaking, the efficacy of radiotherapy for most tumors is positively correlated with the dose of irradiation (13). The general principle for developing radiotherapy strategies is to maximize the dose to tumor-affected tissue while protecting healthy tissue (14).…”

Section: Discussionmentioning

confidence: 99%

Prediction of Radiation Pneumonitis Using Genome-Scale Flux Analysis of RNA-Seq Derived From Peripheral Blood

et al. 2021

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Purpose: Radiation pneumonitis (RP) frequently occurs during a treatment course of chest radiotherapy, which significantly reduces the clinical outcome and efficacy of radiotherapy. The ability to easily predict RP before radiotherapy would allow this disease to be avoided.Methods and Materials: This study recruited 48 lung cancer patients requiring chest radiotherapy. For each participant, RNA sequencing (RNA-Seq) was performed on a peripheral blood sample before radiotherapy. The RNA-Seq data was then integrated into a genome-scale flux analysis to develop an RP scoring system for predicting the probability of occurrence of RP. Meanwhile, the clinical information and radiation dosimetric parameters of this cohort were collected for analysis of any statistical associations between these parameters and RP. A non-parametric rank sum test showed no significant difference between the predicted results from the RP score system and the clinically observed occurrence of RP in this cohort.Results: The results of the univariant analysis suggested that the tumor stage, exposure dose, and bilateral lung dose of V5 and V20 were significantly associated with the occurrence of RP. The results of the multivariant analysis suggested that the exposure doses of V5 and V20 were independent risk factors associated with RP and a level of RP ≥ 2, respectively. Thus, our results indicate that our RP scoring system could be applied to accurately predict the risk of RP before radiotherapy because the scores were highly consistent with the clinically observed occurrence of RP.Conclusion: Compared with the standard statistical methods, this genome-scale flux-based scoring system is more accurate, straightforward, and economical, and could therefore be of great significance when making clinical decisions for chest radiotherapy.

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“…To account for the multicollinearity of HRQOL measures, we employed principal component analysis (PCA) [1]. In looking for opportunities to test these findings, we noted that HRQOL measures have been shown to correlate with survival in a number of disease sites, including lung cancer [2][3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

“…Lung cancer is the leading cause of cancer-related death worldwide with 1.8 million deaths from an estimated 2.2 million new cases in 2020 [8]. HRQOL measures have been shown to correlate with survival in a number of disease sites [2][3][4][5][6][7]. However, studies are heterogenous with regard to stage, treatment, and histology, and many are limited to baseline HRQOL information [2][3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

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A Principal Component of Quality-of-Life Measures Is Associated with Survival: Validation in a Prospective Cohort of Lung Cancer Patients Treated with Stereotactic Body Radiation Therapy

Farrugia

Videtic

et al. 2021

Cancers

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The association between HRQOL metrics and survival has not been studied in early stage non-small-cell lung cancer (NSCLC) patients undergoing SBRT. The cohort was derived via a post-hoc analysis of a prospective randomized clinical trial examining definitive SBRT for peripheral, early-stage NSCLC with a single or multi-fraction regimen. Patients completed HRQOL questionnaires prior to and 3 months after treatment. Using principal component analysis (PCA), changes in each HRQOL scale following treatment were reduced to two eigenvectors, PC1 and PC2. Cox regression was employed to analyze associations with survival-based endpoints. A total of 70 patients (median age 75.6 years; median follow-up 41.1 months) were studied. HRQOL and symptom comparisons at baseline and 3 months were vastly unchanged except for improved coughing (p = 0.02) and pain in the chest at 3 months (p = 0.033). PC1 and PC2 explained 21% and 9% of variance, respectively. When adjusting for covariates, PC1 was significantly correlated with progression-free (PFS) (HR = 0.78, 95% CI 0.67–0.92, p = 0.003) and overall survival (OS) (HR = 0.76, 95% CI 0.46, p = 0.041). Changes in global health status, functional HRQOL performance, and/or symptom burden as described by PC1 values are significantly associated with PFS and OS. The PC1 quartile may facilitate the identification of at-risk patients for additional interventions.

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Impact of pre-radiation therapy quality of life in lung cancer survival: a prospective, intention-to-treat, multicenter study

Cited by 9 publications

References 25 publications

Associated factors with constipation and health-related quality of life in lung cancer patients with platinum-based chemotherapy

Associated factors with constipation and health-related quality of life in lung cancer patients with platinum-based chemotherapy

Prediction of Radiation Pneumonitis Using Genome-Scale Flux Analysis of RNA-Seq Derived From Peripheral Blood

A Principal Component of Quality-of-Life Measures Is Associated with Survival: Validation in a Prospective Cohort of Lung Cancer Patients Treated with Stereotactic Body Radiation Therapy

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