Impact of prealbumin on mortality and hospital readmission in patients with acute heart failure

Franco, Jonathan; Formiga, Francesç; Trullàs, Joan Carles; Salamanca‐Bautista, Prado; Conde, Alicia; Manzano, Luís; Quirós, Raúl Guzmán; Franco, Álvaro González; Ezquerro, Alejandro Martín; Montero-Pérez-Barquero, Manuel

doi:10.1016/j.ejim.2017.05.009

Cited by 29 publications

(15 citation statements)

References 30 publications

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“…In previous studies, the mean (median) serum prealbumin level at discharge in hospitalized heart failure cohort was 18 (20) mg/dL [17,18]. These values are higher than those reported in the present study, indicating that prealbumin may be lower on admission than at discharge in patients with AHF.…”

Section: Discussioncontrasting

confidence: 81%

“…In this study, low prealbumin level on admission ( 14 mg/dL) was independently associated with higher all-cause mortality and the composite endpoints of all-cause death or readmission for AHF. A previous study also demonstrated that patients with low prealbumin level at discharge ( 15 mg/dL) had a significant increase in all-cause mortality [17]. In addition, in the prospective study enrolling 514 patients, Lourenço et al demonstrated that patients with discharge prealbumin 15 mg/dL had a significant excess risk of AHF readmission [18].…”

Section: Discussionmentioning

confidence: 95%

“…is measured [16]. As for hospitalized patients with heart failure, several previous studies have demonstrated that low prealbumin level at discharge is associated with a higher short-term mortality [17,18]. However, the prognostic value of prealbumin level on admission in patients with AHF has not been established, especially in acute and critical care settings.…”

mentioning

confidence: 99%

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Prognostic implications of prealbumin level on admission in patients with acute heart failure referred to a cardiac intensive care unit

Akashi

Minami

Haruki

et al. 2019

Journal of Cardiology

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Section: Discussioncontrasting

confidence: 81%

Section: Discussionmentioning

confidence: 95%

mentioning

confidence: 99%

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Prognostic implications of prealbumin level on admission in patients with acute heart failure referred to a cardiac intensive care unit

Akashi

Minami

Haruki

et al. 2019

Journal of Cardiology

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“… 17 Prealbumin, like albumin, is not only a nutrition screening and assessment tool but also a part of the group of negative acute-phase reactants that decrease in the presence of acute inflammatory diseases. 8 Several studies have demonstrated that prealbumin levels constitute a well-established predictor of short- and long-term outcomes in numerous clinical conditions, including heart failure, 18 , 19 cerebral infarction, 20 and hemodialysis. 21 Recent studies have suggested that prealbumin level is a valuable biomarker for assessing prognosis in patients with AKI.…”

Section: Discussionmentioning

confidence: 99%

Association of prealbumin levels with contrast-induced acute kidney injury in elderly patients with elective percutaneous coronary intervention

You

Lin

Zheng

et al. 2018

CIA

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PurposeInflammatory factors play a critical role in contrast-induced acute kidney injury (CI-AKI). Prealbumin, a nutritional and inflammatory indicator, is a well-established predictor of short- and long-term outcomes in numerous clinical conditions. The current study investigated the association of pre-procedural prealbumin levels with CI-AKI and long-term outcomes in geriatric patients after elective percutaneous coronary intervention (PCI).Patients and methodsA total of 558 patients aged≥75 years, who underwent elective PCI between January 2012 and December 2015, were selected for the current study. Pre-procedural prealbumin levels were measured before PCI. Multivariable logistic regression and Cox proportional hazard regression analyses were performed to identify the independent risk factors for CI-AKI and long-term mortality.ResultsOut of 558 patients, 54 developed CI-AKI. The optimal cutoff value of prealbumin for detecting CI-AKI was 185.5 mg/L with 62.7% sensitivity and 70.4% specificity based on the receiver operating characteristic analysis (C-statistic=0.710; 95% confidence interval [CI] 0.673–0.751). Multivariable analysis demonstrated that prealbumin≤185.5 mg/L was significantly associated with CI-AKI (odds ratio [OR] 0.397; 95% CI 0.195–0.808; P=0.011). Cox regression analysis demonstrated that prealbumin≤185.5 mg/L was associated with long-term mortality (adjusted hazard ratio [HR] 0.525; 95% CI 0.289–0.952; P=0.034) during the follow-up.ConclusionPre-procedural levels of prealbumin were independently associated with an increased risk of CI-AKI and long-term mortality in elderly patients undergoing elective PCI.

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“…84 )134 .Two US studies focused on preventable readmissions. Gunadi et al reported results from a care programme intended to reduce readmission rates, showing that the decrease in variable cost for each avoided hospital readmission was US$5652135 .…”

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confidence: 99%

Humanistic burden and economic impact of heart failure – a systematic review of the literature

et al. 2019

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Background: Heart failure (HF) is increasing in prevalence worldwide. This systematic review was conducted to inform understanding of its humanistic and economic burden. Methods: Electronic databases (Embase, MEDLINE®, and Cochrane Library) were searched in May 2017. Data were extracted from studies reporting health-related quality of life (HRQoL) in 200 patients or more (published 2007–2017), or costs and resource use in 100 patients or more (published 2012–2017). Relevant HRQoL studies were those that used the 12- or 36-item Short-Form Health Surveys, EuroQol Group 5-dimensions measure of health status, Minnesota Living with Heart Failure Questionnaire or Kansas City Cardiomyopathy Questionnaire. Results: In total, 124 studies were identified: 54 for HRQoL and 71 for costs and resource use (Europe: 25/15; North America: 24/50; rest of world/multinational: 5/6). Overall, individuals with HF reported worse HRQoL than the general population and patients with other chronic diseases. Some evidence identified supports a correlation between increasing disease severity and worse HRQoL. Patients with HF incurred higher costs and resource use than the general population and patients with other chronic conditions. Inpatient care and hospitalizations were identified as major cost drivers in HF. Conclusions: Our findings indicate that patients with HF experience worse HRQoL and incur higher costs than individuals without HF or patients with other chronic diseases. Early treatment of HF and careful disease management to slow progression and to limit the requirement for hospital admission are likely to reduce both the humanistic burden and economic impact of HF.

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Impact of prealbumin on mortality and hospital readmission in patients with acute heart failure

Cited by 29 publications

References 30 publications

Prognostic implications of prealbumin level on admission in patients with acute heart failure referred to a cardiac intensive care unit

Prognostic implications of prealbumin level on admission in patients with acute heart failure referred to a cardiac intensive care unit

Association of prealbumin levels with contrast-induced acute kidney injury in elderly patients with elective percutaneous coronary intervention

Humanistic burden and economic impact of heart failure – a systematic review of the literature

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