Impact of prehypertension on carotid artery intima–media thickening: Actual or masked?

Michas, F.; Tsivgoulis, Georgios; Stamatelopoulos, Kimon; Tsagalis, Georgios; Koroboki, Eleni; Alexaki, E; Papamichael, Christos; Vemmos, Konstantinos

doi:10.1016/j.atherosclerosis.2010.10.032

Cited by 17 publications

(8 citation statements)

References 21 publications

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“… 25 However, a recent study suggested that actual prehypertensive and normotensive subjects did not differ significantly in terms of CCA-IMT values. 26 In our study, there was no significant difference in the increased CIMT positive rate between prehypertensives subjects and normotensive ones after adjustment of confounders.…”

Section: Discussioncontrasting

confidence: 57%

Association of prehypertension and hyperhomocysteinemia with subclinical atherosclerosis in asymptomatic Chinese: a cross-sectional study

et al. 2018

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ObjectivesComorbid hypertension and hyperhomocysteinemia is an important risk factor for carotid atherosclerotic plaque formation. We put forward the hypothesis that the subjects with comorbid prehypertension and hyperhomocysteinemia also had an increased risk of subclinical atherosclerosis, using carotid intima–media thickness (CIMT) as the marker of the atherosclerotic process.MethodsA total of 4102 asymptomatic Chinese subjects aged 18–60 years were divided into four groups according to blood pressure (BP) and homocysteine (HCY) level: the control group without prehypertension or hyperhomocysteinemia, isolated prehypertension group, simple hyperhomocysteinemia group and prehypertension with hyperhomocysteinemia group. Serum lipids, fasting blood glucose (FBG), HCY and CIMT were measured.ResultsThere was significant difference in the positive rates of increased CIMT among four groups. Compared with the controls, the subjects in the other three groups had a higher risk of increased CIMT (isolated prehypertension group, OR 2.049, 95% CI 1.525 to 2.754; simple hyperhomocysteinemia group, OR 2.145, 95% CI 1.472 to 3.125; prehypertension and hyperhomocysteinemia group, OR 3.199, 95% CI 2.362 to 4.332). However, by multiple logistic regression analysis, only comorbid prehypertension and hyperhomocysteinemia was independently associated with increased CIMT (OR 1.485, 95% CI 1.047 to 2.108, P<0.05).ConclusionsComorbid prehypertension and hyperhomocysteinemia was an independent risk factor of subclinical atherosclerosis in asymptomatic Chinese, but isolated prehypertension or hyperhomocysteinemia was not. Therefore, combined intervention for prehypertension and hyperhomocysteinemia may contribute to decrease the incident of cardiovascular disease.

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Section: Discussioncontrasting

confidence: 57%

Association of prehypertension and hyperhomocysteinemia with subclinical atherosclerosis in asymptomatic Chinese: a cross-sectional study

et al. 2018

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“…In normotensives from the present randomly selected community sample, only 14% had day BP values that exceeded 135/85 mmHg (masked hypertension). In contrast, in employees of a university hospital or private company [40] or in referrals to a hypertension clinic [41] 34 and 24.7%, respectively, of those with a normal/highnormal BP had masked hypertension and only those with masked hypertension had target organ changes. As masked hypertension is independently associated with cardiovascular outcomes, it is possible that ambulatory BP monitoring also has an important role to play in further refining risk in those with a normal/high-normal BP, at least in groups with a high prevalence of masked hypertension.…”

Section: Aortic Blood Pressure In Normotensivesmentioning

confidence: 64%

Aortic, but not brachial blood pressure category enhances the ability to identify target organ changes in normotensives

Booysen

Norton

Maseko

et al. 2013

Journal of Hypertension

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“…Moreover, our study is one of the largest population‐based studies to assess the association between BP, assessed by 24‐hour ABP monitoring, and cIMT …”

Section: Discussionmentioning

confidence: 99%

Intima–Media Thickness Is Linearly and Continuously Associated With Systolic Blood Pressure in a Population‐Based Cohort (STANISLAS Cohort Study)

Ferreira

Girerd

Bozec

et al. 2016

JAHA

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BackgroundCarotid intima–media thickness (cIMT) is a noninvasive marker of cardiovascular risk. The cIMT may be increased in patients with harmonisation, but little is known regarding the functional form of the association between blood pressure (BP) and cIMT in hypertensive and nonhypertensive persons. We aimed to define the shape of the association between BP and cIMT.Methods and ResultsWe studied cIMT and ambulatory BP monitoring data from a single‐center, cross‐sectional, population‐based study involving 696 adult participants from the STANISLAS cohort, a familial longitudinal cohort from the Nancy region of France. Participants with a history of hypertension were more likely to have a cIMT >900 μm and had higher mean cIMT (both P<0.001). The risk of cIMT >900 μm increased linearly with higher 24‐hour and daytime systolic BP in participants both with and without history of hypertension. The relationship between systolic BP and the risk of cIMT >900 μm was not dependent on hypertension status (all P for interaction >0.10). In multivariable analysis adjusted on cardiovascular risk factors, each 5‐mm Hg increase in systolic BP was associated with an 8‐μm increase in cIMT (β=8.249 [95% CI 2.490–14.008], P=0.005). In contrast, the association between diastolic BP and cIMT was weaker and not significant.ConclusionsSystolic BP is linearly and continuously associated with higher cIMT in both hypertensive and nonhypertensive persons, suggesting a detrimental effect of BP on the vascular tree prior to overt hypertension. Similarly, it suggests a detrimental effect of BP at the higher end of the normal range in treated hypertensive patients.Clinical Trial Registration URL: https://www.clinicaltrials.gov/. Unique identifier: NCT01391442.

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Impact of prehypertension on carotid artery intima–media thickening: Actual or masked?

Cited by 17 publications

References 21 publications

Association of prehypertension and hyperhomocysteinemia with subclinical atherosclerosis in asymptomatic Chinese: a cross-sectional study

Association of prehypertension and hyperhomocysteinemia with subclinical atherosclerosis in asymptomatic Chinese: a cross-sectional study

Aortic, but not brachial blood pressure category enhances the ability to identify target organ changes in normotensives

Intima–Media Thickness Is Linearly and Continuously Associated With Systolic Blood Pressure in a Population‐Based Cohort (STANISLAS Cohort Study)

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