Impact of Procaine Hydrochloride Versus Lidocaine in Cardioplegic Solution, on Reperfusion Arrhythmia During Coronary Artery Bypass Graft Surgery

Abstract

Background: The best way to reduce the occurrence of arrhythmias that generally occur after an open heart surgery is to improve the quality of myocardial protection against reperfusion damage during the cross-clamp time. In this regard, different cardioplegic solutions play a key role. Differences in the types and contents of cardioplegic solutions may lead to different results of effective protection of the myocardium. The purpose of this study was to compare the effects of the newly introduced procaine hydrochloride (PHC) containing cardioplegic solution (Shahid Ghazi Pharmaceutical Co. Tabriz, Iran) and lidocaine (L) in cardioplegic solution on post aortic clamp arrhythmia in coronary artery bypass graft surgery.

Myocardial protection in cardiac surgery: Del Nido versus blood cardioplegia

“…Sadeghi et al . [ 12 ] in a study comparing cardioplegia using lignocaine or procaine had similar findings. The study by Sellevold et al .…”

“…Both are Class 1 sodium channel blockers that directly block the sodium channels in phase 0 depolarization of the action potential. [ 11 12 ] Compared with procaine, lignocaine has a longer half-life. [ 12 ] This gave DNC group the advantage of longer ischemic times between doses of cardioplegia.…”

“…[ 11 12 ] Compared with procaine, lignocaine has a longer half-life. [ 12 ] This gave DNC group the advantage of longer ischemic times between doses of cardioplegia. The redosing for DNC is significantly less, which allowed the surgeons to do an uninterrupted surgery with better workflow.…”