Impact of processing on the bioavailability and vascular effects of blueberry (poly)phenols

Rodriguez-Mateos, Ana; Pino-García, Raquel Del; George, Trevor; Vidal‐Diez, Alberto; Heiß, Christian; Spencer, Jeremy P. E.

doi:10.1002/mnfr.201400231

Cited by 93 publications

(115 citation statements)

References 35 publications

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“…In addition to the factors examined in this meta-analysis, other important factors that may play a critical role in the inter-individual variability and can contribute to explain the lack of consistent evidence in humans of the beneficial cardiometabolic effects of the ANC- and ET-containing food products (as well as of other polyphenol-containing foods and extracts) are: bioavailability of all these compounds and their derived metabolites [182,183], individuals enterotypes and functional stratification of the gut microbiome profile (i.e., metabotypes) [31,184,185], and the (epi)genetic characteristics of the host individual.…”

Section: Discussionmentioning

confidence: 99%

“…In this regard, some studies have been conducted with polyphenol-rich berry products in comparison with nutrient-matched controls to try to associate the polyphenols intake with the response of the individuals [30]. Also, the association between the intake of ET-containing pomegranate products and the effects on cardiometabolic risk factors has been investigated with some evidence of a potential link between responses and specific ET-derived metabolites, but the effects of other constituents of these products have not been fully discarded [31,32]. At present, specific associations between pure ANCs or ETS and cardiometabolic effects remain unproved.…”

Section: Introductionmentioning

confidence: 99%

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Meta-Analysis of the Effects of Foods and Derived Products Containing Ellagitannins and Anthocyanins on Cardiometabolic Biomarkers: Analysis of Factors Influencing Variability of the Individual Responses

Garcı́a-Conesa

Chambers

Combet

et al. 2018

IJMS

119

107

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Understanding interindividual variability in response to dietary polyphenols remains essential to elucidate their effects on cardiometabolic disease development. A meta-analysis of 128 randomized clinical trials was conducted to investigate the effects of berries and red grapes/wine as sources of anthocyanins and of nuts and pomegranate as sources of ellagitannins on a range of cardiometabolic risk biomarkers. The potential influence of various demographic and lifestyle factors on the variability in the response to these products were explored. Both anthocyanin- and ellagitannin-containing products reduced total-cholesterol with nuts and berries yielding more significant effects than pomegranate and grapes. Blood pressure was significantly reduced by the two main sources of anthocyanins, berries and red grapes/wine, whereas waist circumference, LDL-cholesterol, triglycerides, and glucose were most significantly lowered by the ellagitannin-products, particularly nuts. Additionally, we found an indication of a small increase in HDL-cholesterol most significant with nuts and, in flow-mediated dilation by nuts and berries. Most of these effects were detected in obese/overweight people but we found limited or non-evidence in normoweight individuals or of the influence of sex or smoking status. The effects of other factors, i.e., habitual diet, health status or country where the study was conducted, were inconsistent and require further investigation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Meta-Analysis of the Effects of Foods and Derived Products Containing Ellagitannins and Anthocyanins on Cardiometabolic Biomarkers: Analysis of Factors Influencing Variability of the Individual Responses

Garcı́a-Conesa

Chambers

Combet

et al. 2018

IJMS

119

107

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“…For example, blueberry consumption has been shown to improve endothelial function in young healthy men and in people with metabolic syndrome [9,10], and decrease blood pressure and arterial stiffness in pre-and hypertensive postmenopausal women and people with the metabolic syndrome [11,12]. Increasing evidence also suggests that the high polyphenol content of berries may be responsible for their beneficial effects [8,9,[13][14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Bioavailability of wild blueberry (poly)phenols at different levels of intake

Rodriguez-Mateos

Feliciano

Cifuentes-Gomez

et al. 2016

JBR

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Abstract. BACKGROUND:Data from human intervention studies have highlighted potential cardiovascular benefits of blueberry (poly)phenols. However, such biological effects are dependent on their bioavailability and, as such, information on the absorption, metabolism and excretion of such compounds is necessary. OBJECTIVE: To investigate whether the bioavailability of blueberry (poly)phenols is intake-dependent, a group of nine healthy volunteers consumed three wild blueberry drinks containing 766 mg (lower), 1278 mg (medium) and 1791 mg (higher) total (poly)phenols, corresponding to 34, 56 and 80 g, respectively, freeze-dried blueberry powder. METHODS: Plasma levels of (poly)phenol metabolites were assessed at baseline and at 1, 2, 4 and 6 hours post-consumption, using UPLC-Q-TOF mass spectrometry. RESULTS: Twenty-three phenolic acid metabolites were quantified in plasma after blueberry consumption. Increases in plasma (poly)phenol metabolites were observed in all the interventions tested. The area under the curve of the concentration over time (AUC) significantly increased when comparing the lower and higher (poly)phenol interventions. Linear doseresponse regressions were obtained for 11 metabolites, while the plasma concentration of the remaining 12 metabolites was not affected by increasing amounts of (poly)phenols in the blueberry interventions. CONCLUSION: Absorption and metabolism of blueberry (poly)phenols are not exclusively intake-dependent at the amounts tested, evidencing a complex metabolic fate of these compounds.

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“…These organic molecules are known mainly for their antioxidant properties. They help reduce the risk of cardiovascular disease and act as antibacterial, antiviral and anti-inflammatory agents [3,4]. They are also involved in sensory (astringency, bitterness) and nutritional properties [5].…”

mentioning

confidence: 99%

Phenolic compound explorer: A mid-infrared spectroscopy database

Abbas

Compère

Larondelle

et al. 2017

Vibrational Spectroscopy

111

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Impact of processing on the bioavailability and vascular effects of blueberry (poly)phenols

Abstract: Careful processing can preserve important biological activities of blueberries despite changing the blueberry (poly)phenol composition and plasma metabolite profile.

Cited by 93 publications

References 35 publications

Meta-Analysis of the Effects of Foods and Derived Products Containing Ellagitannins and Anthocyanins on Cardiometabolic Biomarkers: Analysis of Factors Influencing Variability of the Individual Responses

Meta-Analysis of the Effects of Foods and Derived Products Containing Ellagitannins and Anthocyanins on Cardiometabolic Biomarkers: Analysis of Factors Influencing Variability of the Individual Responses

Bioavailability of wild blueberry (poly)phenols at different levels of intake

Phenolic compound explorer: A mid-infrared spectroscopy database

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