Impact of Prolonged Temporal Discrimination Threshold on Finger Movements of Parkinson’s Disease

Lee, M. J.; Son, Jongsang; Lee, J. H.; Kim, S. J.; Lyoo, Chul Hyoung; Lee, M. S.

doi:10.1371/journal.pone.0167034

Cited by 14 publications

(13 citation statements)

References 31 publications

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“…Previous studies have proved that index finger tapping is significantly correlated with Lind-mark hand function assessment score and it plays an important role in hand function evaluation in patients with stroke (Zhang et al, 2014 ). The finger tapping is usually used to assess movement bradykinesia patients with Parkinson's disease patients (Lee et al, 2016 ). Moreover, a finger tapping test has been applied to measure performance validity in most of the standard neuropsychological evaluations (Axelrod et al, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

Finger Tapping Outperforms the Traditional Scale in Patients With Peripheral Nerve Damage

Zhang

Zhao

et al. 2018

Front. Physiol.

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Objective: This study aimed to investigate whether there exist the limits of finger tapping frequency in the peripheral nerve injury detection in upper limb, and the effects of rehabilitation treatment on upper limb with peripheral nerve injury through finger tapping.Methods: Here, 54 patients with peripheral nerve injury in upper limb were selected. We conducted finger tapping frequency test and Lind-mark hand function assessment score on the 54 subjects, and recorded the data 2-week before and after rehabilitation treatment.Results: Finger tapping frequency and Lind-mark hand function assessment score have a high positive correlation regardless of the side of upper limb with peripheral nerve injury before and after the rehabilitation treatment. Finger tapping frequency of the right affected hand after treatment is significantly higher than that of before treatment (male: P < 0.05; female: P < 0.01), while finger tapping frequency of the left affected hand after treatment shows no significant difference compared to before treatment. Meanwhile, finger tapping frequency of the female subjects' unaffected hand after treatment is significantly higher than before treatment (left: P < 0.01; right: P < 0.05), however, this was not observed in male subjects. Based on data analysis, there is a high-correlation between finger tapping frequency and Lind-mark score of the patients' affected hand with brachial plexus nerve injury. A trend of the patients' affected hand with radial nerve injury is similar with brachial plexus nerve injury.Conclusion: Compared with Lind-mark score, finger tapping frequency outperformed in the aspect of speed of neural impulse conduction in patients with peripheral nerve damage.

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Section: Discussionmentioning

confidence: 99%

Finger Tapping Outperforms the Traditional Scale in Patients With Peripheral Nerve Damage

Zhang

Zhao

et al. 2018

Front. Physiol.

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“…On the same line, STDT changes are present when dystonic features are not yet manifested in patients with increased blinking, a condition now considered to be a prodromal manifestation of blepharospasm [ 38 , 39 ]. Different from dystonia in other basal ganglia conditions, like Parkinson's disease, STDT changes reflect dopaminergic depletion [ 40 , 41 ] and disease progression [ 42 , 43 ].…”

Section: Discussionmentioning

confidence: 99%

Does the Somatosensory Temporal Discrimination Threshold Change over Time in Focal Dystonia?

et al. 2017

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Background The somatosensory temporal discrimination threshold (STDT) is defined as the shortest interval at which an individual recognizes two stimuli as asynchronous. Some evidence suggests that STDT depends on cortical inhibitory interneurons in the basal ganglia and in primary somatosensory cortex. Several studies have reported that the STDT in patients with dystonia is abnormal. No longitudinal studies have yet investigated whether STDT values in different forms of focal dystonia change during the course of the disease. Methods We designed a follow-up study on 25 patients with dystonia (15 with blepharospasm and 10 with cervical dystonia) who were tested twice: upon enrolment and 8 years later. STDT values from dystonic patients at the baseline were also compared with those from a group of 30 age-matched healthy subjects. Results Our findings show that the abnormally high STDT values observed in patients with focal dystonia remained unchanged at the 8-year follow-up assessment whereas disease severity worsened. Conclusions Our observation that STDT abnormalities in dystonia remain unmodified during the course of the disease suggests that the altered activity of inhibitory interneurons—either at cortical or at subcortical level—responsible for the increased STDT does not deteriorate as the disease progresses.

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“…Since the STDT in PD is normal at disease onset, which suggests that STDT abnormalities only appear when dopamine loss reaches a threshold that may be higher than that associated with the onset of motor symptoms ( 6 ), it may be considered as a marker of disease progression ( 6 ). Recent studies on PD ( 45 , 50 ) have suggested that an abnormal STDT might be involved in the development of parkinsonian motor deficits. The correlation between STDT values and variables that assess movement performance point to a possible link between altered STDT and motor disturbances in PD ( 8 , 45 ).…”

Section: Evidence On Actual and Illusory Tactile Information Processimentioning

confidence: 99%

“…Recent studies on PD ( 45 , 50 ) have suggested that an abnormal STDT might be involved in the development of parkinsonian motor deficits. The correlation between STDT values and variables that assess movement performance point to a possible link between altered STDT and motor disturbances in PD ( 8 , 45 ). In a study designed to investigate how STDT-related circuits interact with motor performance ( 50 , 106 ), we observed that the STDT increases at movement onset and returns to baseline values after 200 ms. We suggested that the increase in STDT during movement execution is likely to reflect mechanisms of sensory gating of tactile information that are irrelevant to the ongoing movement.…”

Section: Evidence On Actual and Illusory Tactile Information Processimentioning

confidence: 99%

Actual and Illusory Perception in Parkinson's Disease and Dystonia: A Narrative Review

2018

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Sensory information is continuously processed so as to allow behavior to be adjusted according to environmental changes. Before sensory information reaches the cortex, a number of subcortical neural structures select the relevant information to send to be consciously processed. In recent decades, several studies have shown that the pathophysiological mechanisms underlying movement disorders such as Parkinson's disease (PD) and dystonia involve sensory processing abnormalities related to proprioceptive and tactile information. These abnormalities emerge from psychophysical testing, mainly temporal discrimination, as well as from experimental paradigms based on bodily illusions. Although the link between proprioception and movement may be unequivocal, how temporal tactile information abnormalities and bodily illusions relate to motor disturbances in PD and dystonia is still a matter of debate. This review considers the role of altered sensory processing in the pathophysiology of movement disorders, focusing on how sensory alteration patterns differ between PD and dystonia. We also discuss the evidence available and the potential for developing new therapeutic strategies based on the manipulation of multi-sensory information and bodily illusions in patients with these movement disorders.

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Impact of Prolonged Temporal Discrimination Threshold on Finger Movements of Parkinson’s Disease

Cited by 14 publications

References 31 publications

Finger Tapping Outperforms the Traditional Scale in Patients With Peripheral Nerve Damage

Finger Tapping Outperforms the Traditional Scale in Patients With Peripheral Nerve Damage

Does the Somatosensory Temporal Discrimination Threshold Change over Time in Focal Dystonia?

Actual and Illusory Perception in Parkinson's Disease and Dystonia: A Narrative Review

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