Impact of red meat consumption on the metabolome of rats

Abstract

This study is the first to identify specific differences in the metabolome related to the intake of red and white meat. These differences may reflect perturbations in endogenous metabolism that can be linked to the proposed harmful effects associated with intake of red meat.

Intake of Oxidized Proteins and Amino Acids and Causative Oxidative Stress and Disease: Recent Scientific Evidences and Hypotheses

“…It is worth noting that such connection does not necessarily require the presence of oxidation products (that are naturally present in most food systems), as the sustained intake of considerable amounts of unsaturated lipids or animal proteins (both sensitive to oxidation) has been found to increase oxidation and inflammation markers in blood of humans and experimental animals. To exemplify, Jakobsen et al (2017), Turner et al (2017), and Van Hecke et al…”

“…The interconnection between all these terms is illustrated in Figure 1. Disappointingly, Kanner et al (2017) identify such a diet as a "meal rich in lipids" though it is certainly known that proteinrich foods, such as lean red meat causes postprandial oxidative stress, inflammation, and increased risk to suffer serious diseases, as aforementioned (Jakobsen et al, 2017;Turner et al, 2017). It is assumed that oxidizing lipids play a major role in the pathogenesis of oxidative-driven pathologies while proteins are considered mere recipients of posttranslational changes.…”

“…T ª = 80 °C for 3.5 hr) is 80 nmol/mg protein while the concentration of such protein oxidation products in soy protein isolate heated for 8 hr at 100 °C is only 10 nmol/mg protein (Zhang et al., ). A sustained intake of red meat has been found to increase markers of inflammation and systemic oxidative damage to lipids and proteins in experimental animals (Jakobsen et al., ; Turner, Keogh, Meikle, & Clifton, ; Van Hecke et al., ). Conversely, a sustained intake of soy protein has negligible impacts on oxidative stress and blood lipids (Engelman, Alekel, Hanson, Kanthasamy, & Reddy, ).…”

Plasma Metabolomics Reveals Steroidal Alkaloids as Novel Biomarkers of Tomato Intake in Mice

“…Using high resolution LC‐MS metabolomics, thousands of small molecule metabolites can be detected in a single analysis of a biological sample, such as urine or blood. In addition to host‐derived physiological metabolites, the resulting metabolomic profile includes compounds derived from the diet, which can serve as biomarkers of specific dietary components . Identification of these metabolites allows for better assessment of compliance in dietary interventions, as well as more robust biomarkers of diet quality .…”

Background Diet Influences TMAO Concentrations Associated with Red Meat Intake without Influencing Apparent Hepatic TMAO-Related Activity in a Porcine Model

“…Koeth et al (2013) found that circulating TMAO levels were higher for subjects consuming meat than vegetarians and that TMAO accelerated atherosclerosis in mice [11]. An association between meat intake and TMAO has also been indicated in later studies targeted at discovering biomarkers related to red meat intake [13][14][15]. However, other dietary factors, such as fish consumption, also affect plasma TMAO levels [16].…”