Impact of resistance exercises and nano-curcumin on synovial levels of collagenase and nitric oxide in women with knee osteoarthritis

Abstract

Background: Osteoarthritis is the most common joint damage that leads to cartilage destruction, pain, and disability. The aim of this study is to investigate the effects of resistance exercises and Nano curcumin supplementation on synovial levels of collagenase-2 and NO in patients with knee osteoarthritis. Methods: Forty women with primary knee osteoarthritis were divided into four groups including control, exercise, supplementation, and supplementation /exercises. The resistance exercise group performed exercises in 16 weeks (three sessions per week). The supplement group consumed one Nano curcumin capsule (1000 mg) per day for 16 weeks. Exercise and supplementation group also performed resistance exercises along with consuming Nano curcumin. Synovial fluid samplings were done in two stages of pre-test (24 h before training and supplementation) and post-test (48 h after the last session of treatment and supplementation). The obtained synovial fluid was used to measure the synovial level of collagenase-II and nitric oxide. Results: Although, there were not any significant correlations between resistance exercise, nanocurcumum supplementation, and synovial levels of collagenase-2 and NO among women with knee osteoarthritis, we observed interesting reduced levels of both markers following the supplementation. Conclusions: It can be concluded that the Nano curcumin supplementation can be an effective method to reduce the levels of these inflammatory factors in synovial fluids of cases with knee Osteoarthritis. Longer duration of the protocol may have more promoting results. Trial registration: The project was registered at Iranian Registry of Clinical Trials (Trial registration number: IRCT20161208031300N1).

Ameliorative Effect of Curcumin Nanoparticles against Monosodium Iodoacetate-Induced Knee Osteoarthritis in Rats

“…Furthermore, CUR-loaded PLGA NP treatment during OA inhibited the expression of iNOS, which is an inflammation-induced enzyme that catalyzes the production of the proinflammatory mediator nitric oxide (NO), further demonstrating its anti-inflammatory effects. Several in vivo and in vitro studies [36,37] have shown that CUR treatment reduces iNOS production in various inflammatory diseases. Most recently, Cheragh-Birjandi et al [37] postulated that 10 Mediators of Inflammation in turn promote the expression of a variety of matrixdegrading enzymes, including metalloproteinases (MMPs) [38][39][40].…”

“…Several in vivo and in vitro studies [36,37] have shown that CUR treatment reduces iNOS production in various inflammatory diseases. Most recently, Cheragh-Birjandi et al [37] postulated that 10 Mediators of Inflammation in turn promote the expression of a variety of matrixdegrading enzymes, including metalloproteinases (MMPs) [38][39][40]. In the early stage of OA, high upregulation of MMP-13 expression, a prominent catabolic enzyme, leads to severe deterioration of cartilage as it induces type II collagen, which is a reason for nearly 90% of the ECM.…”

Curcumin and Freshwater Clam Extracts Alleviate the Progression of Osteoarthritis by Reducing Synovial Inflammation and Allowing Cartilage Regeneration

“…Physiological microenvironments can be modulated or influenced by curcumin and FCE. Curcumin can inhibit the production of inflammatory mediators such as nitric oxide (NO), prostaglandin2 (PGE2), IL-6, and IL-8 stimulated by IL-1β [11,12,38]. Additionally, curcumin prevents IL-1β-induced NF-κB activation and translocation, giving rise to reduced expression of the NF-κB downstream pro-inflammatory gene COX-2 [39].…”

A review of therapeutic potentials of turmeric (Curcuma longa) and its active constituent, curcumin, on inflammatory disorders, pain, and their related patents

“…Hence, it was concluded that curcumin can be an alternate cure in patients with knee osteoarthritis who cannot tolerate the adverse effects of nonsteroidal anti‐inflammatory drugs (NSAIDs) (Shep, Khanwelkar, Gade, & Karad, 2019). The data of another clinical trial displayed that nano curcumin supplementation (1,000 mg/day, 16 weeks) might be a potent method to attenuate the amounts of inflammatory markers including nitric oxide (NO) and collagenase‐2 in synovial fluids of patients suffering from knee osteoarthritis (Cheragh‐Birjandi et al, 2020). In another double‐blind randomized placebo trial conducted on 72 older adults with knee pain associated with osteoarthritis, curcumin 5% ointment twice daily for 6 weeks, significantly decreased the mean pain intensity (Jamali, Adib‐Hajbaghery, & Soleimani, 2020).…”