Impact of Rutin and Vitamin C combination on oxidative stress and glycemic control in patients with type 2 diabetes

Ragheb, Sara Ramzy; Wakeel, Lamia Mohamed El; Nasr, Merhan Samy; Sabri, Nagwa Ali

doi:10.1016/j.clnesp.2019.10.015

Cited by 47 publications

(45 citation statements)

References 20 publications

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“…Quercetin, isoquercitrin and rutin are three common supplements, given that their nutritional values benefit human health (Xu et al 2021; Ragheb et al 2020; da Silva et al 2019; Kolarevic et al 2019; Seifert 2013; Amanzadeh et al 2019). Our data suggest that quercetin, isoquercitrin, and rutin might be helpful to intervene COVID-19.…”

Section: Discussionmentioning

confidence: 99%

Flavonols and dihydroflavonols inhibit the main protease activity of SARS-CoV-2 and the replication of human coronavirus 229E

Zhu

Scholle

et al. 2021

Preprint

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Since December 2019, the deadly novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the current COVID-19 pandemic. To date, vaccines are available in the developed countries to prevent the infection of this virus, however, medicines are necessary to help control COVID-19. Human coronavirus 229E (HCoV-229E) causes the common cold. The main protease (Mpro) is an essential enzyme required for the multiplication of these two viruses in the host cells, and thus is an appropriate candidate to screen potential medicinal compounds. Flavonols and dihydroflavonols are two groups of plant flavonoids. In this study, we report docking simulation with two Mpro enzymes and five flavonols and three dihydroflavonols, in vitro inhibition of the SARS-CoV-2 Mpro, and in vitro inhibition of the HCoV 229E replication. The docking simulation results predicted that (+)-dihydrokaempferol, (+)-dihydroquercetin, (+)-dihydromyricetin, kaempferol, quercetin, myricentin, isoquercetin, and rutin could bind to at least two subsites (S1, S1', S2, and S4) in the binding pocket and inhibit the activity of SARS-CoV-2 Mpro. Their affinity scores ranged from -8.8 to -7.4. Likewise, these compounds were predicted to bind and inhibit the HCoV-229E Mpro activity with affinity scores ranging from -7.1 to -7.8. In vitro inhibition assays showed that seven available compounds effectively inhibited the SARS-CoV-2 Mpro activity and their IC50 values ranged from 0.125 to 12.9 uM. Five compounds inhibited the replication of HCoV-229E in Huh-7 cells. These findings indicate that these antioxidative flavonols and dihydroflavonols are promising candidates for curbing the two viruses.

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Section: Discussionmentioning

confidence: 99%

Flavonols and dihydroflavonols inhibit the main protease activity of SARS-CoV-2 and the replication of human coronavirus 229E

Zhu

Scholle

et al. 2021

Preprint

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“…A prospective clinical study revealed a significant (p < 0.05) decrease in fasting glucose by 6.46% in 1 g of vitamin C for 2 weeks compared to the control group. The authors correlated this observed effect with the antioxidant capacity of vitamin C (Ragheb et al, 2020). Vitamin K affects insulin sensitivity because it decreases pro-inflammatory cytokine production (Yan & Khalil, 2017).…”

Section: Vitaminsmentioning

confidence: 95%

Cabbage (Brassica oleracea var. capitata): A food with functional properties aimed to type 2 diabetes prevention and management

Narvaez

Campos

2021

Journal of Food Science

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Type 2 diabetes mellitus (T2DM) is increasing the prevalence worldwide at an alarming rate, becoming a serious public health problem that mainly affects developing countries. Functional food research is currently of great interest because it contributes to developing nutritional therapy strategies for T2DM prevention and treatment. Bioactive compounds identified in some plant foods contribute to human health by mechanisms of action that exert biological effects on metabolic pathways involved in the development of T2DM. Hence, vegetables with high bioactive compounds content may be a source of functional value for the control of T2DM. Cabbages varieties (Brassica oleracea var. capitata) such as green (GCB), white (WCB), and red (RCB) are foods consumed (raw or cooked) and cultivated in different regions of the world. Scientific evidence shows that cabbage has multi-target effects on glucose homeostatic regulation due to its high content of bioactive compounds. It has also been shown to decrease damage to organs affected by T2DM complications, such as the liver and kidney. Additionally, it could contribute as a preventive by attenuating problems underlying the development of T2DM as oxidative stress and obesity. This review highlights the functional properties of cabbage varieties involved in glucose regulation and the main mechanisms of the action exerted by their bioactive compounds. In conclusion, cabbage is a valuable food that can be employed as part of nutritional therapy or functional ingredient aimed at the prevention and treatment of T2DM.

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“…No side effects have been reported for supplementation with 500 mg of rutin per day [37]. However, this study will controlled by a Data Monitoring Committee (DMC).…”

Section: Safety Adverse Effects and Monitoring Datamentioning

confidence: 98%

The Effects of Rutin Flavonoid Supplementation on Brain White Matter and Gray Matter Abnormalities in Type 2 Diabetes Mellitus Patients: A Diffusion Tensor Imaging -Based Study Protocol for a Double-Blind, Randomized Controlled Trial

Moghadam

Javid

Asl

et al. 2021

Preprint

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Background: Brain microstructural changes in white matter (WM) and gray matter (GM) of type 2 diabetes mellitus (T2DM) patients can be explained using Diffusion Tensor Imaging (DTI) method. Increased oxidative stress has been recognized the key factor in T2DM induce neural damage. Rutin flavonoid plays protective roles in several oxidative stress-mediated neurodegenerative disorders. So, the effects of rutin on WM and GM continuous changes in T2DM patients requires to be more investigated.Method: We will conduct a 3 months, double-blind, randomized controlled clinical trial to examine the effects of rutin supplementation on WM and GM changes in 26 T2DM cases. The intervention group (n=13) and the control group (n=13) will receive one tablet of 1 g rutin/day and one tablet of 1 g placebo/day after meals, respectively. Before and after the intervention, DTI will perform at 1.5 Tesla, followed by an analysis employing tract-based spatial statistics (TBSS) to explore the changes in fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (λ1), and radial diffusivity (λ23) among the rutin and placebo treated groups. A receiver operating characteristic (ROC) test will use to evaluate the performance of DTI criteria for cutting off the two T2DM groups. Discussion: We will demonstrate the diverse influences of rutin supplementation on WM and GM integrity on T2DM patients. Since, rutin may regulate neurotoxicity, oxidative stress, inflammatory reaction and nitric oxide production in nervous system; for the first time, the effects of rutin on WM and GM alterations will be evaluated by DTI in T2DM patients. Trial registration: Iran Clinical Trials Registry, registration number: IRCT20151128025274N6. Registered on 10 January 2021, https://fa.irct.ir/user/trial/53283/view

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Impact of Rutin and Vitamin C combination on oxidative stress and glycemic control in patients with type 2 diabetes

Cited by 47 publications

References 20 publications

Flavonols and dihydroflavonols inhibit the main protease activity of SARS-CoV-2 and the replication of human coronavirus 229E

Flavonols and dihydroflavonols inhibit the main protease activity of SARS-CoV-2 and the replication of human coronavirus 229E

Cabbage (Brassica oleracea var. capitata): A food with functional properties aimed to type 2 diabetes prevention and management

The Effects of Rutin Flavonoid Supplementation on Brain White Matter and Gray Matter Abnormalities in Type 2 Diabetes Mellitus Patients: A Diffusion Tensor Imaging -Based Study Protocol for a Double-Blind, Randomized Controlled Trial

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