Impact of short-chain fatty acid supplementation on gut inflammation and microbiota composition in a murine colitis model

Lee, Jae Gon; Lee, Ji-Young; Lee, Areum; Jo, Su Vin; Park, Chan Hyuk; Han, Dong Soo; Eun, Chang Soo

doi:10.1016/j.jnutbio.2021.108926

Cited by 43 publications

(29 citation statements)

References 47 publications

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“…In addition, feeding 1% QUR for 16 weeks increased the production of short-chain fatty acids [ 66 ]. Short-chain fatty acids are energy-regulating signal molecules generated by carbohydrate metabolism of intestinal flora, which can improve insulin sensitivity [ 98 ], down-regulate inflammatory factors [ 99 ] and promote fatty acid oxidation [ 100 , 101 ]. Therefore, we believe that QUR can have a positive effect on PCOS by increasing the proportion of beneficial bacteria and the content of short-chain fatty acids.…”

Section: Effect and Mechanism Of Quercetin In Polycystic Ovary Syndromementioning

confidence: 99%

Potential Role of Quercetin in Polycystic Ovary Syndrome and Its Complications: A Review

Chen

Fan

et al. 2022

Molecules

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Polycystic ovary syndrome (PCOS) is a common multisystem disease with reproductive, metabolic and psychological abnormalities. It is characterized by a high prevalence rate in women of childbearing age and highly heterogeneous clinical manifestations, which seriously harm women’s physical and mental health. Quercetin (QUR) is a natural compound of flavonoids found in a variety of foods and medicinal plants. It can intervene with the pathologic process of PCOS from multiple targets and channels and has few adverse reactions. It is mentioned in this review that QUR can improve ovulation disorder, relieve Insulin resistance (IR), reduce androgen, regulate lipid metabolism, regulate gut microbiota and improve vascular endothelial function, which is of great significance in the treatment of PCOS.

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Section: Effect and Mechanism Of Quercetin In Polycystic Ovary Syndromementioning

confidence: 99%

Potential Role of Quercetin in Polycystic Ovary Syndrome and Its Complications: A Review

Chen

Fan

et al. 2022

Molecules

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“…The differences in time settings of butyrate administration in groups 3 and 4 may be crucial due to various levels of butyrate, as the ability of gut microbiota to synthesize butyrate as well, as butyrate uptake and utilization by colonocytes is impaired in IBD patients depending on the severity of inflammation ( Laserna-Mendieta et al, 2018 ). Moreover, supplementation with butyrate has been shown to affect significantly the composition of gut microbiota ( Lee et al, 2022 ), and previous studies on the gnotobiotic mice have revealed that the regulation of CYP3A is very sensitive to the interventions in the gut microbial community ( Selwyn et al, 2016 ; Jourová et al, 2017 ). In another study, a strong correlation of some genus from the bacterial family Clostridiaceae, butyrate-producing bacterial family , and Cyp3a activity in mice was observed.…”

Section: Discussionmentioning

confidence: 99%

“…We hypothesize that oral administration of sodium butyrate may simultaneously increase the portion of butyrate reaching the liver and directly affect hepatic drug metabolism. Also, butyrate administration may influence hepatic CYPs regulation indirectly, through affecting gut microbiota composition and immune cell differentiation ( Lee et al, 2022 ). We also suggest that the effect of butyrate administration may vary under physiological and inflammatory states as it has been published previously that patients with UC have impaired butyrate metabolism and uptake ( De Preter et al, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

Butyrate Treatment of DSS-Induced Ulcerative Colitis Affects the Hepatic Drug Metabolism in Mice

et al. 2022

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The development of inflammatory bowel disease (IBD) is associated with alterations in the gut microbiota. There is currently no universal treatment for this disease, thus emphasizing the importance of developing innovative therapeutic approaches. Gut microbiome-derived metabolite butyrate with its well-known anti-inflammatory effect in the gut is a promising candidate. Due to increased intestinal permeability during IBD, butyrate may also reach the liver and influence liver physiology, including hepatic drug metabolism. To get an insight into this reason, the aim of this study was set to clarify not only the protective effects of the sodium butyrate (SB) administration on colonic inflammation but also the effects of SB on hepatic drug metabolism in experimental colitis induced by dextran sodium sulfate (DSS) in mice. It has been shown here that the butyrate pre-treatment can alleviate gut inflammation and reduce the leakiness of colonic epithelium by restoration of the assembly of tight-junction protein Zonula occludens-1 (ZO-1) in mice with DSS-induced colitis. In this article, butyrate along with inflammation has also been shown to affect the expression and enzyme activity of selected cytochromes P450 (CYPs) in the liver of mice. In this respect, CYP3A enzymes may be very sensitive to gut microbiome-targeted interventions, as significant changes in CYP3A expression and activity in response to DSS-induced colitis and/or butyrate treatment have also been observed. With regard to medications used in IBD and microbiota-targeted therapeutic approaches, it is important to deepen our knowledge of the effect of gut inflammation, and therapeutic interventions were followed concerning the ability of the organism to metabolize drugs. This gut–liver axis, mediated through inflammation as well as microbiome-derived metabolites, may affect the response to IBD therapy.

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“…In their experiments SCFAs did reduce innate immune activation in tissues; yet, depending on the condition, also increased effector activity of CD4 + T cells, which in turn aggravated inflammation [ 86 ]. In a recent trial with oral SCFA administration, Lee et al (2022) showed an increase in both Treg and Th17 cells in the colon of mice subjected to a DSS-induced model of IBD after a 14-day oral administration of butyrate or a mix of butyrate, acetate and propionate, but did not observe attenuation of inflammation [ 87 ].…”

Section: Scfa Interventions In Inflammatory Disordersmentioning

confidence: 99%

Regulation of CD4+ and CD8+ T Cell Biology by Short-Chain Fatty Acids and Its Relevance for Autoimmune Pathology

Schiweck

Thanrajah

Aichholzer

et al. 2022

IJMS

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The gut microbiota encodes a broad range of enzymes capable of synthetizing various metabolites, some of which are still uncharacterized. One well-known class of microbiota-derived metabolites are the short-chain fatty acids (SCFAs) such as acetate, propionate, butyrate and valerate. SCFAs have long been considered a mere waste product of bacterial metabolism. Novel results have challenged this long-held dogma, revealing a central role for microbe-derived SCFAs in gut microbiota-host interaction. SCFAs are bacterial signaling molecules that act directly on host T lymphocytes by reprogramming their metabolic activity and epigenetic status. They have an essential biological role in promoting differentiation of (intestinal) regulatory T cells and in production of the anti-inflammatory cytokine interleukin-10 (IL-10). These small molecules can also reach the circulation and modulate immune cell function in remote tissues. In experimental models of autoimmune and inflammatory diseases, such as inflammatory bowel disease, multiple sclerosis or diabetes, a strong therapeutic potential of SCFAs through the modulation of effector T cell function was observed. In this review, we discuss current research activities toward understanding a relevance of microbial SCFA for treating autoimmune and inflammatory pathologies from in vitro to human studies.

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Impact of short-chain fatty acid supplementation on gut inflammation and microbiota composition in a murine colitis model

Cited by 43 publications

References 47 publications

Potential Role of Quercetin in Polycystic Ovary Syndrome and Its Complications: A Review

Potential Role of Quercetin in Polycystic Ovary Syndrome and Its Complications: A Review

Butyrate Treatment of DSS-Induced Ulcerative Colitis Affects the Hepatic Drug Metabolism in Mice

Regulation of CD4+ and CD8+ T Cell Biology by Short-Chain Fatty Acids and Its Relevance for Autoimmune Pathology

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