Impact of short-course therapy on tuberculosis drug resistance in South-West Burkina Faso

Drug Resistance of <i>Mycobacterium tuberculosis</i> Complex among Newly Diagnosed Tuberculosis Cases in Burkina Faso

“…23 The global resistance of M tuberculosis to anti-TB drugs (12.4%) in our study was lower than the 23.5% found in Ghana. 22 As Ledru et al 8 , in their study in BoboDioulasso, we did not find a relationship between HIV serostatus and drug resistance.…”

“…The MDR-TB rate in BoboDioulasso, the second largest city in Burkina Faso in 1992-1994 was 1.8%. 8 Some of the reasons for the drug resistance observed could be that the treatment success rate in new smear positive cases has not improved ever since the NTP was initiated in 1995. Another factor to be noted was the introduction of the private health sector in the detection and treatment of TB which operates differently from the public health sector.…”

“…The last epidemiological study on DST in new cases of TB in Burkina Faso was done from April 1992 to April 1994. 8 More than ten years after, we undertook this study to update the data on the level of drug resistance in Mycobacterium tuberculosis complex strains among newly diagnosed TB cases in Burkina Faso.We also assessed the relationship between resistance to TB drugs and the HIV serostatus among TB patients.…”

PCR-based detection of the Mycobacterium tuberculosis complex in urine of HIV-infected and uninfected pulmonary and extrapulmonary tuberculosis patients in Burkina Faso

“…The last study available (1994) showed that the prevalence of HIV antibodies among Burkinabe TB patients was 33 . 6 % (Ledru et al, 1996). In other subSaharan African countries the rates of HIV infection among TB patients are even higher (44 .…”

Promoting adherence to treatment for tuberculosis: the importance of direct observation

“…In public health practice, failure to ensure treatment observation has been associated with a significantly increased risk of relapse, 7 often compounded by the emergence of drug resistance; treatment observation has been shown to reduce both relapse and drug resistance. [8][9][10][11] In short-term studies reporting no difference in cure rates with or without direct observation of treatment, it is possible that significant numbers of post-treatment relapses and the development and spread of drug-resistant strains are not apparent. If direct observation is to be replaced with administration of treatment by the patient or by the family, the potential community impact of patient non-adherence must be considered.…”