Impact of simultaneous hydrolysis of OCP and PLGA on bone induction of a PLGA-OCP composite scaffold in a rat femoral defect

Oizumi, Itsuki; Hamai, Ryo; Mori, Yu; Anada, Takahisa; Baba, Kazuyoshi; Miyatake, Naohisa; Hamada, Soshi; Tsuchiya, Kaori; Nishimura, Shinya; Itoi, Eiji; Сузукі, Осаму

doi:10.1016/j.actbio.2021.01.048

Cited by 30 publications

(20 citation statements)

References 67 publications

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“…In addition, the variation of the LA:GA ratio directly impacts the copolymer’s crystallinity and T g values. Thanks to their particular Tg variations (40–60 °C) [ 77 , 78 ], PLGA-based biomaterials are promising candidates for applications that require direct contact with structures of the human body. Because of the nontoxicity of PLGA and its degradation products, together with their non-immunogenicity and physiological metabolization, this copolymer is highly recommended for the fabrication of platforms that enable the controlled, targeted and triggerable delivery of therapeutic agents [ 79 , 80 ].…”

Section: Resultsmentioning

confidence: 99%

Bioactive Ibuprofen-Loaded PLGA Coatings for Multifunctional Surface Modification of Medical Devices

et al. 2021

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To modulate the biofunctionality of implantable medical devices commonly used in clinical practice, their surface modification with bioactive polymeric coatings is an attractive and successful emerging strategy. Biodegradable coatings based on poly(lactic acid-co-glycolic acid), PLGA, represent versatile and safe candidates for surface modification of implantable biomaterials and devices, providing additional tunable ability for topical delivery of desired therapeutic agents. In the present study, Ibuprofen-loaded PLGA coatings (PLGA/IBUP) were obtained by using the dip-coating and drop-casting combined protocol. The composite materials demonstrated long-term drug release under biologically simulated dynamic conditions. Reversible swelling phenomena of polymeric coatings occurred in the first two weeks of testing, accompanied by the gradual matrix degradation and slow release of the therapeutic agent. Irreversible degradation of PLGA coatings occurred after one month, due to copolymer’s hydrolysis (evidenced by chemical and structural modifications). After 30 days of dynamic testing, the cumulative release of IBUP was ~250 µg/mL. Excellent cytocompatibility was revealed on human-derived macrophages, fibroblasts and keratinocytes. The results herein evidence the promising potential of PLGA/IBUP coatings to be used for surface modification of medical devices, such as metallic implants and wound dressings.

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Section: Resultsmentioning

confidence: 99%

Bioactive Ibuprofen-Loaded PLGA Coatings for Multifunctional Surface Modification of Medical Devices

et al. 2021

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“…In clinical settings, bone defects are usually treated using autologous bone grafting or bone graft substitutes. We had created bilateral cortical bone defects with a diameter of 3 mm in rat femur, simulating bone defects that cannot be repaired spontaneously, and investigated the mechanism of bone repair using octacalcium phosphate composite [4]. It would be more clinically meaningful to evaluate the effect of enoxaparin on bone healing using autologous bone grafting or bone graft substitutes.…”

Section: To the Editormentioning

confidence: 99%

Impacts of low molecular weight heparin on bone healing and osseointegration

Mori

Aizawa

2022

J Bone Miner Metab

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“…Among a variety of materials for bone tissue engineering, polylactic glycolic acid copolymer (PLGA) has been approved by US Food and Drug Administration (FDA) for human use due to its good biocompatibility and biodegradability ( Jia et al, 2016 ). However, although PLGA is widely used in various tissue engineering applications, it still has the problems of mismatched mechanical and unsatisfactory biological properties owing to the low stiffness between PLGA-based implants and natural bones and the hydrophobic surface of PLGA-based scaffolds ( Zou et al, 2020 ; Jin et al, 2021 ; Oizumi et al, 2021 ; Wei et al, 2021 ; Zhao et al, 2021 ). Many researchers address these problems by introducing inorganic material in the modification of PLGA-based scaffolds.…”

Section: Introductionmentioning

confidence: 99%

Customized Design 3D Printed PLGA/Calcium Sulfate Scaffold Enhances Mechanical and Biological Properties for Bone Regeneration

Liu

Zhao

et al. 2022

Front. Bioeng. Biotechnol.

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Polylactic glycolic acid copolymer (PLGA) has been widely used in tissue engineering due to its good biocompatibility and degradation properties. However, the mismatched mechanical and unsatisfactory biological properties of PLGA limit further application in bone tissue engineering. Calcium sulfate (CaSO4) is one of the most promising bone repair materials due to its non-immunogenicity, well biocompatibility, and excellent bone conductivity. In this study, aiming at the shortcomings of activity-lack and low mechanical of PLGA in bone tissue engineering, customized-designed 3D porous PLGA/CaSO4 scaffolds were prepared by 3D printing. We first studied the physical properties of PLGA/CaSO4 scaffolds and the results showed that CaSO4 improved the mechanical properties of PLGA scaffolds. In vitro experiments showed that PLGA/CaSO4 scaffold exhibited good biocompatibility. Moreover, the addition of CaSO4 could significantly improve the migration and osteogenic differentiation of MC3T3-E1 cells in the PLGA/CaSO4 scaffolds, and the PLGA/CaSO4 scaffolds made with 20 wt.% CaSO4 exhibited the best osteogenesis properties. Therefore, calcium sulfate was added to PLGA could lead to customized 3D printed scaffolds for enhanced mechanical properties and biological properties. The customized 3D-printed PLGA/CaSO4 scaffold shows great potential for precisely repairing irregular load-bearing bone defects.

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Impact of simultaneous hydrolysis of OCP and PLGA on bone induction of a PLGA-OCP composite scaffold in a rat femoral defect

Cited by 30 publications

References 67 publications

Bioactive Ibuprofen-Loaded PLGA Coatings for Multifunctional Surface Modification of Medical Devices

Bioactive Ibuprofen-Loaded PLGA Coatings for Multifunctional Surface Modification of Medical Devices

Impacts of low molecular weight heparin on bone healing and osseointegration

Customized Design 3D Printed PLGA/Calcium Sulfate Scaffold Enhances Mechanical and Biological Properties for Bone Regeneration

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