Impact of Sleep Disorder as a Risk Factor for Dementia in Men and Women

Jee, Hye Jin; Shin, Weon Ho; Jung, Ho Joong; Kim, Baekgyu; Lee, Bo Kyung; Jung, Yi-Sook

doi:10.4062/biomolther.2019.192

Cited by 39 publications

(20 citation statements)

References 175 publications

(176 reference statements)

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“…[ 5 ] Long term insomnia not only brings great trouble to people's life and work, but also causes diseases such as depression, [ 6 ] anxiety disorders, [ 7 ] heart disease, [ 8 ] stroke, [ 9 ] hypertension, [ 10 ] diabetes, [ 11 ] dementia. [ 12 ] Meanwhile, insomnia is associated with an increased risk of car crashes, as well as injuries at home and at work. [ 13 ] Insomnia, and its comorbid problems, leads to high societal costs, mainly due to productivity losses.…”

Section: Introductionmentioning

confidence: 99%

Guipi decoction for insomnia

Lan

Wen

et al. 2020

Medicine

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Background: Insomnia is a common sleep disorder with symptoms including difficulty falling asleep and early awakening. Guipi decoction is widely used in clinical treatment of insomnia in China. However, there is a lack of systematic evaluation and analysis of Guipi decoction. Therefore, our study will provide efficacy assessments and adverse events assessments. Methods: A comprehensive search for randomized controlled trials of Gupi decoction treatments for insomnia will be carried in MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trial (CENTRAL), CINAHL, AMED and Chinese databases include CBM, CNKI, CQVIP, and Wanfang from their inceptions to May 2020. Relevant reference lists, Baidu Scholar and grey literature will also be checked. Two experienced reviewers will independently search all databases. Primary outcomes include Pittsburgh sleep quality index and clinical effective rate, and secondary outcomes include traditional Chinese medicine syndrome, adverse events, and Epworth Sleepiness Scale. Review Manager 5.3 software will be used analyze all data. Results: This article will be dedicated to assessing the efficacy and safety of Guipi decoction for insomnia. Conclusion: The conclusion of this systematic review will provide evidence to judge whether Guipi Decoction is an effective therapeutic intervention for patient with insomnia. Maybe these results could potentially be helpful for improving the therapeutic strategy of patients with insomnia. PROSPERO registration number: CRD 42020164911.

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Section: Introductionmentioning

confidence: 99%

Guipi decoction for insomnia

Lan

Wen

et al. 2020

Medicine

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“…The elderly have been associated with increased night sleep disturbances whose prevalence is estimated to be approximately 50% (2,3). Sleep disturbances in this population has adverse effects including an increased risk of dementia, hypertension, diabetes, obesity, depression, heart attack, and stroke (4,5). Alzheimer's disease (AD) is a dementia syndrome in which cognitive impairment interferes with the performance of daily activities.…”

Section: Introductionmentioning

confidence: 99%

Association of Sleep Disturbances With Longitudinal Cognitive Decline Among Cognitively Normal Elders

Feng¹,

Kuetche²,

Zhang³

et al. 2021

Preprint

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Background: A lot of evidence demonstrated sleep disturbances (SD) gets associated with Alzheimer’s disease (AD), but whether or not sleep disturbances could be the preclinical stage of AD is still unknown.Objective: 463 cognitively normal elders (357 normal and 106 SD) in baseline with cognitive and biomarker data were included in the study. Participants were collected from 2005 to 2020 (16 years follow-up) in the Alzheimer’s Disease Neuroimaging Initiative (ADNI). The generalized linear mixed models adjusting variables selected by the Akaike Information Criterion (AIC) and the marginal effect estimation method were used to estimate the effect of SD for cognition. Moreover, Cox regression was used to assess the survival risk of AD in sleep disturbance.Results: The age range of participants was 73.60±5.71 years old, and the female proportion was 43.63%. Compared with the group with normal sleep, those with sleep disturbances had worse mean scores at 6 years on the PACC (mean difference, 7.53 points [95%CI, 7.36-7.70]; P<0.001), MMSE (mean difference, 5.26 points [95%CI, 5.17-5.35]; P<0.001), and CDR–Sum of Boxes (mean difference, 5.61 points [95%CI, 5.67-5.54]; P = 0.001). Cox regression analysis suggested that sleep disturbances is a risk factor of AD (HR=1.55, 95% CI=1.08 to 2.22).Conclusion: Research of a cognitively normal cohort followed up for a mean of 9.56 years suggest that sleep disturbances, compared with normal sleep status, was associated with higher likelihood cognitive, which means sleep disturbances could probably be the pre-symptomatic stage of AD.

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“…The elderly have been associated with increased night sleep disturbance whose prevalence is estimated to be approximately 50% 2 . Sleep disturbance in this population has adverse effects including an increased risk of dementia, hypertension, diabetes, obesity, depression, heart attack, and stroke 3,4 . Alzheimer's disease (AD) is a dementia syndrome in which cognitive impairment interferes with the performance of daily activities.…”

Section: Introductionmentioning

confidence: 99%

Association of Sleep Disturbance With Longitudinal Cognitive Decline Among Cognitively Normal Elders

Feng

Kuetche

Zhang

et al. 2021

Preprint

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Background: A lot of evidence demonstrated sleep disturbance (SD) gets associated with Alzheimer’s disease (AD), but whether or not sleep disturbance could be the preclinical stage of AD is still unknown.Objective: 463 cognitively normal elders (357 normal and 106 SD) in baseline with cognitive and biomarker data were included in the study. Participants were collected from 2005 to 2020 (16 years follow-up) in the Alzheimer’s Disease Neuroimaging Initiative (ADNI).Methods: A generalized linear mixed model was used to adjust time variables and other covariates selected by the Akaike Information Criterion (AIC). Besides, the marginal effect estimation method was used to evaluate the interaction between sleep disturbance and time on cognitive decline. Cox regression was used to assess the survival risk of AD in sleep disturbance.Results: The age range of participants was 73.60±5.71 years old, and the female proportion was 43.63%. Taking time as a continuous variable in longitudinal analyses, it was found that sleep disturbance had a significant long-term negative effect on MMSE, PACC, CSF Aβ, and ventricular volume (P<0.05). Cox regression analysis showed that sleep disturbance is a significant risk factor of AD (HR=1.55, 95% CI=1.08 to 2.22).Conclusion: Sleep disturbance in baseline was associated with subsequent cognitive decline among cognitively normal elders and is an increased risk of AD, which means sleep disturbance could probably be the pre-symptomatic stage of AD.

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Impact of Sleep Disorder as a Risk Factor for Dementia in Men and Women

Cited by 39 publications

References 175 publications

Guipi decoction for insomnia

Guipi decoction for insomnia

Association of Sleep Disturbances With Longitudinal Cognitive Decline Among Cognitively Normal Elders

Association of Sleep Disturbance With Longitudinal Cognitive Decline Among Cognitively Normal Elders

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