Impact of socioeconomic risk factors on the seroprevalence of cytomegalovirus infections in a cohort of pregnant Polish women between 2010 and 2011

Wujcicka, Wioletta; Gaj, Zuzanna; Wilczyński, J; Sobala, Wojciech; Spiewak, Ewa; Nowakowska, Dorota

doi:10.1007/s10096-014-2170-3

Cited by 23 publications

(42 citation statements)

References 42 publications

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“…On the other hand, comparison of our seroprevalence with those reported in other countries suggests that the seroprevalence of CMV infection in pregnant women in Durango could be placed in an intermediate position of endemicity. The 65.6% seroprevalence found in pregnant women in Durango is similar to the 62.4%-66% seroprevalences reported in pregnant women in Poland [13], Japan [14], and Norway [15], and higher than the 49% seroprevalence in white British pregnant women in the United Kingdom [16] and a 42.3% seroprevalence in pregnant women in Germany [17]. In contrast, the seroprevalence found in pregnant women in Durango is lower than the 92.6%-100% seroprevalences reported in pregnant women in Iran [18], Palestine [19], Brazil [20], Turkey [21], Nigeria [22], and Cuba [23].…”

Section: Discussionsupporting

confidence: 81%

Seroepidemiology of cytomegalovirus infection in pregnant women in Durango City, Mexico

et al. 2014

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BackgroundCytomegalovirus causes congenital infections all around the world. The seroepidemiology of cytomegalovirus infection in pregnant women in Mexico is largely unknown. We sought to determine the seroprevalence of cytomegalovirus infection in pregnant women in Durango City, Mexico; and to determine seroprevalence association with socio-demographic, clinical and behavioral characteristics of pregnant women.MethodsThrough a cross-sectional study design, 343 pregnant women were examined for anti-cytomegalovirus IgG and IgM antibodies in Durango City, Mexico. We used a standardized questionnaire to obtain the general characteristics of the pregnant women. Multivariate analysis was performed to determine the association of cytomegalovirus infection with the characteristics of the pregnant women.ResultsAnti-CMV IgG and IgM antibodies were detected in 225 (65.6%) and in none of the 343 pregnant women studied, respectively. Multivariate analysis showed that CMV exposure was associated with increasing age (OR = 1.67; 95% CI: 1.01-2.76; P = 0.04). Other women characteristics including socioeconomic status, education, blood transfusion, transplantation, sexual promiscuity and number of previous pregnancies or deliveries did not show an association with CMV exposure.ConclusionsThis is the first seroepidemiology study of CMV infection in pregnant women in Mexico. A number of known factors associated with CMV infection were not associated with CMV exposure in the women studied. Further studies to determine routes of CMV infection in pregnant women in Mexico are needed.

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Section: Discussionsupporting

confidence: 81%

Seroepidemiology of cytomegalovirus infection in pregnant women in Durango City, Mexico

et al. 2014

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“…Similarly, significantly higher prevalence rates of anti-HCMV IgG and IgM antibodies determined among the infected pregnant women studied in this paper, as compared to the previously reported cohort of Polish pregnant women between 2010 and 2011, as well as to other European populations, are possibly also caused by a classification of the patients to the presented study [4–7]. So far, it has been the first study to reveal a really significant role of TLR9 2848 G > A SNP in the occurrence of HCMV infection in pregnant women.…”

Section: Discussionsupporting

confidence: 57%

“…Human cytomegalovirus (HCMV) is the most common cause of intrauterine infections worldwide, with seroprevalence rates at the range from 40 to 100% among pregnant women [1–4]. Our recent study, performed among Polish pregnant women between 2010 and 2011, showed seroprevalence of anti-HCMV IgG and IgM antibodies to have been 62.4 and 2.2%, respectively [4].…”

Section: Introductionmentioning

confidence: 99%

“…Our recent study, performed among Polish pregnant women between 2010 and 2011, showed seroprevalence of anti-HCMV IgG and IgM antibodies to have been 62.4 and 2.2%, respectively [4]. Compared to other European populations of pregnant women from the Netherlands (41%), France (46%) and the United Kingdom (49%), the prevalence of IgG anti-HCMV in the Polish pregnancy cohort was still high [5–7].…”

Section: Introductionmentioning

confidence: 99%

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Toll-like receptors genes polymorphisms and the occurrence of HCMV infection among pregnant women

Wujcicka

Paradowska

Studzińska

et al. 2017

Virol J

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BackgroundHuman cytomegalovirus (HCMV) is the most common cause of intrauterine infections worldwide. The toll-like receptors (TLRs) have been reported as important factors in immune response against HCMV. Particularly, TLR2, TLR4 and TLR9 have been shown to be involved in antiviral immunity. Evaluation of the role of single nucleotide polymorphisms (SNPs), located within TLR2, TLR4 and TLR9 genes, in the development of human cytomegalovirus (HCMV) infection in pregnant women and their fetuses and neonates, was performed.MethodsThe study was performed for 131 pregnant women, including 66 patients infected with HCMV during pregnancy, and 65 age-matched control pregnant individuals. The patients were selected to the study, based on serological status of anti-HCMV IgG and IgM antibodies and on the presence of viral DNA in their body fluids. Genotypes in TLR2 2258 A > G, TLR4 896 G > A and 1196 C > T and TLR9 2848 G > A SNPs were determined by self-designed nested PCR-RFLP assays. Randomly selected PCR products, representative for distinct genotypes in TLR SNPs, were confirmed by sequencing. A relationship between the genotypes, alleles, haplotypes and multiple variants in the studied polymorphisms, and the occurrence of HCMV infection in pregnant women and their offsprings, was determined, using a logistic regression model.ResultsGenotypes in all the analyzed polymorphisms preserved the Hardy-Weinberg equilibrium in pregnant women, both infected and uninfected with HCMV (P > 0.050). GG homozygotic and GA heterozygotic status in TLR9 2848 G > A SNP decreased significantly the occurrence of HCMV infection (OR 0.44 95% CI 0.21–0.94 in the dominant model, P ≤ 0.050). The G allele in TLR9 SNP was significantly more frequent among the uninfected pregnant women than among the infected ones (χ2 = 4.14, P ≤ 0.050). Considering other polymorphisms, similar frequencies of distinct genotypes, haplotypes and multiple-SNP variants were observed between the studied groups of patients.Conclusions TLR9 2848 G > A SNP may be associated with HCMV infection in pregnant women.Electronic supplementary materialThe online version of this article (doi:10.1186/s12985-017-0730-8) contains supplementary material, which is available to authorized users.

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“…Studies on the prevalence of CMV in childbearing-aged, pregnant and parturient women showed seroprevalence rates of 42.3% in Germany [32], 49% in the United Kingdom [35], 56.3% in Finland [36], 57% in France [22], 62.4% in Poland [37] and 91.5%-97.3% in Turkey [24,38]. Regional differences in CMV seropositivity were observed in Norway (58.5%-72.1%) [23,39] and Belgium (30%-54%) [21,31].…”

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confidence: 99%

Seroepidemiology of cytomegalovirus infections in Croatia

Vilibić-Čavlek

Kolarić

Beader

et al. 2016

Wien Klin Wochenschr

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Objectives: Cytomegalovirus (CMV) is endemic worldwide, with marked differences in the seroprevalence rates between countries. The aim of this study was to analyze the seroprevalence of CMV infection in Croatia. Methods:During a three year period (2013)(2014)(2015), 2438 consecutive serum samples collected from Croatian residents were tested for the presence of CMV IgM and IgG antibodies using enzyme-linked immunoassay. IgM/IgG positive samples were further tested for IgG avidity. Results:The overall seroprevalence rates for CMV IgG and IgM antibodies were 74.4% and 4.3%, respectively. The IgG seroprevalence differed significantly between population groups: children/adolescents 54.6%, adult general population 77.2%, hemodialysis patients 91.4% (p<0.001). CMV seropositivity was strongly age-dependent with prevalence ranging from 53.0% in children less than 10 years to 93.8% in persons above 60 years (p<0.001). There was no difference in the prevalence between women with normal pregnancy and women with bad obstetric history. Gender and place of residence was not associated with CMV seropositivity.Using IgG avidity, current/recent primary CMV infection was confirmed by low/borderline avidity index (AI) in 46.7% participants, while in 53.3% high AI indicated CMV reactivation or reinfection. Primary infections were detected mainly in children and adolescents (83.2% and 70.5%), while reactivations/reinfections were common in persons older than 40 (77.0-100%). Reactivations/reinfections were most commonly detected in hemodialysis patients (92.3%). Logistic regression showed that older age and being on hemodialysis were significant predictors of CMV seropositivity.Conclusions: CMV is widespread in the Croatian population. Older age and being on hemodialysis appeared to be main risk factors for CMV infection.

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Impact of socioeconomic risk factors on the seroprevalence of cytomegalovirus infections in a cohort of pregnant Polish women between 2010 and 2011

Cited by 23 publications

References 42 publications

Seroepidemiology of cytomegalovirus infection in pregnant women in Durango City, Mexico

Seroepidemiology of cytomegalovirus infection in pregnant women in Durango City, Mexico

Toll-like receptors genes polymorphisms and the occurrence of HCMV infection among pregnant women

Seroepidemiology of cytomegalovirus infections in Croatia

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