Impact of Specific Beers Criteria Medications on Associations between Drug Exposure and Unplanned Hospitalisation in Elderly Patients Taking High-Risk Drugs: A Case-Time-Control Study in Western Australia

Abstract

Indomethacin and temazepam should be prescribed cautiously in elderly patients, especially in drug combinations. Furthermore, it appears other antirheumatics should be favoured over indomethacin/naproxen and, in situations where both drugs may be appropriate, digoxin over amiodarone. Our methodology may help assess the safety of new medications in drug combinations in preliminary pharmacovigilance investigations.

Association between Potentially Inappropriate Medication (PIM) Use and Risk of Hospitalization in Older Adults: An Observational Study Based on Routine Data Comparing PIM Use with Use of PIM Alternatives

“…PIM use among the elderly is known to be associated with an increased risk of hospitalization through ADEs, drug interactions, or intolerability [ 25 ]. Several recently published papers have addressed this and other adverse effects of PIMs [ 8 , 10 , 15 , 16 , 25 – 27 ]. However, the heterogeneity of these extensive drug lists (PRISCUS, Beers, and others) poses a challenge when identifying an appropriate control group.…”

“…Two recent papers also addressed the question of whether or not the risk of hospitalization increases when PIM drugs defined in the PRISCUS and/or Beers’ list are taken [ 15 , 16 ]. In particular, the results of Reich, et al can be compared with ours.…”

Prevalence of depressive symptoms and factors associated in the elderly of the city of Pelotas-RS

“…Sedentary participants presented a higher prevalence of depressive symptoms even after adjusted analysis, corroborating systematic reviews that show a positive association between physical activity and mental health 23,24,25,26 . The literature suggests that active individuals have a greater capacity for social interaction, improved mood 27 and cognitive ability 28 , as well as less susceptibility to stress 29,30 , thus being less likely to present depressive signs and symptoms. During physical exercise a number of changes in neuroendocrine mechanisms, such as increased secretion of serotonin and endorphin, occur 31 .…”

Polypharmacy and use of potentially inappropriate medications in long-term care facilities: does coordinated primary care make a difference?

“…However, the Beers list is a well‐respected tool which is arguably more clinically accessible to prescribers given its ease of use. Beers Criteria has also been associated with negative outcomes including Emergency Department visits and hospitalizations . Furthermore, adverse drug events remain an important cause of morbidity and are associated with inappropriate medication use, regardless of whether implicit or explicit criteria are used .…”