Impact of static electric field on prooxidant‐antioxidant balance in rats

Cieślar, Grzegorz; Małyszek‐Tumidajewicz, Justyna; Sowa, Paweł; Sieroń, Aleksander

doi:10.1108/03321641211227483

Cited by 9 publications

(6 citation statements)

References 15 publications

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“…However, Cieslar et al . 39 found that SEF with similar intensities (25 and 35 kV/m) could cause compensatory and multidirectional changes in the activities of various antioxidant enzymes (SOD, GSH-Px and catalase) in rats liver on the 14 th and 28 th day of exposures (8 hours/day). The difference of two results could be mainly attribute to the variance in experimental animals and daily exposure duration.…”

Section: Discussionmentioning

confidence: 95%

Studies on effects of static electric field exposure on liver in mice

Lin

Liu

Xu³

et al. 2018

Sci Rep

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With the development of ultra-high-voltage direct-current transmission, the intensity of static electric field (SEF) under transmission lines increased, which has aroused public attention on its potential health effects. In order to examine effects of SEF exposure on liver, institute of cancer research mice were exposed to SEF with intensities of 27.5 kV/m, 34.7 kV/m and 56.3 kV/m, respectively. In each intensity of SEF exposure, a corresponding sham exposure group was used. Several indices relating to liver function (aspartate aminotransferase (AST) and alanine aminotransferase (ALT)) and oxidative stress (superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and malondialdehyde (MDA)) were tested after exposure of 7, 14, 21 and 35 days. Results showed that exposure to SEF with intensities of 27.5 kV/m and 34.7 kV/m for 35 days did not significantly influence any detected indices above. Under SEF exposure with intensity of 56.3 kV/m, the SOD activity in liver was significantly increased after exposure of 7 and 14 days. However, no significant increase was found in MDA content as well as the activities of AST and ALT between exposure group and sham exposure group during SEF exposure of 56.3 kV/m. It suggested that from three SEF intensities, only exposure to SEF with intensity of 56.3 kV/m (7 and 14 days) caused a temporary oxidative stress response in liver expressed by the increase in activity of SOD, but it did not produce oxidative damage. This biological effect may be related to the increase of mitochondrial membrane potential of hepatocytes caused by SEF exposure. When the membrane potential exceeds a threshold, Q cycle in mitochondria will be affected, which will result in an increase of superoxide anion concentration and ultimately an oxidative stress.

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Section: Discussionmentioning

confidence: 95%

Studies on effects of static electric field exposure on liver in mice

Lin

Liu

Xu³

et al. 2018

Sci Rep

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“…A vital part of homeostasis is the maintenance of the balance of pro-and anti-oxidant systems within the body. Many experimental studies have confirmed that electromagnetic fields with various physical parameters could intensify the generation of reactive oxygen species (ROS) with subsequent disturbances of a balance between an intensity of oxidant processes and capacity of antioxidant defense system, depending on the activity of antioxidant enzymes and non-enzymatic antioxidants [7][8][9][10][11]. This toxic phenomenon, called oxidative stress, results in stimulation of the process of membrane lipid peroxidation in the form of direct oxidation cell membrane thiol groups (-SH) by reactive oxygen species with subsequent disintegration of their structure and increase of permeability, leading in consequence to the development of apoptosis and cell death [10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Influence of Electromagnetic Fields on Prooxidant/Antioxidant Balance in Rat Liver

Sieroń–Stołtny¹,

Pasek²,

Cieślar³

et al. 2017

Pol. J. Environ. Stud.

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The potential health consequences of common exposure of human organisms to high-voltage industrial frequency and radio-frequency electromagnetic fields have not yet been completely recognized. The aim of this study was to evaluate the impact of a 50 Hz electromagnetic field generated by high-voltage alternating electric current transmission lines, a 900 MHz electromagnetic field emitted by mobile phones, and simultaneous exposure to those forms of electromagnetic fields on prooxidant and antioxidant processes in the liver tissue of 40 male rats randomly divided into three experimental groups exposed to different forms of electromagnetic fields and a control sham-exposed one. After completing 28 daily exposures in obtained liver tissue homogenates we determined the contents of markers of prooxidant processes (total oxidant capacity and malone dialdehyde), as well as activity of selected antioxidant enzymes (superoxide dismutase, its isoenzymes Cu,Zn-SOD and Mn-SOD, catalase and glutathione peroxidase). Moreover, cell ultrastructures in specimens from liver samples were examined under an electron microscope. A four-week exposure to a high-voltage 50 Hz electromagnetic field did not affect the prooxidant/antioxidant balance in the liver tissue of rats, while exposure to the radiofrequency electromagnetic field emitted by a mobile phone and simultaneous exposure to both forms of electromagnetic field significantly inhibited the intensity of prooxidant processes and decreased the activity of antioxidant enzymes in liver tissue, especially in the case of simultaneous action of both fields-probably due to their excessive use for restoring

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“…DNA damage observed in our work may result from free radical action since activation of prooxidant processes was shown for this physical factor [Seyhan and Güler, ; Cieslar et al, ; Harutyunyan and Shakyan, ].…”

Section: Discussionmentioning

confidence: 77%

Effect of in vivo and in vitro exposure to electrostatic field on some hematological parameters in rats

Harutyunyan

Mkrtchyan

Sukiasyan

et al. 2016

Bioelectromagnetics

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The aim of this study was to investigate the effect of the external electrostatic field (ESF) on some hematological parameters in rats. Both in vivo and in vitro experiments were carried out. In in vivo investigations, rats were exposed to ESF (200 kV/m) during short (1 h) and long periods (6 days, 6 h daily). For in vitro study, the blood of intact rats was exposed to ESF for 1 h. Blood hematology was measured using validated ABX Micros ESV 60 Veterinary Hematology Analyzer. DNA damage in blood leucocytes was detected by means of comet assay. ESF effect on blood cell count was mainly manifested in white blood cells (WBC) and platelets. Damage of WBC was shown both in vitro and in vivo despite alterations in the count. This means the observed increase in WBC count in some cases might be a result of WBC compensatory mobilization from the bone marrow. Red blood cell (RBC) count and related parameters were slightly affected by ESF. Nevertheless, alterations in the shape and size of RBC were manifested. All ESF effects were extinguished in 14 days after the end of exposure. Bioelectromagnetics. 37:513-526, 2016. © 2016 Wiley Periodicals, Inc.

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Impact of static electric field on prooxidant‐antioxidant balance in rats

Cited by 9 publications

References 15 publications

Studies on effects of static electric field exposure on liver in mice

Studies on effects of static electric field exposure on liver in mice

Influence of Electromagnetic Fields on Prooxidant/Antioxidant Balance in Rat Liver

Effect of in vivo and in vitro exposure to electrostatic field on some hematological parameters in rats

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