Impact of Supplementation with Curcuminoids on Systemic Inflammation in Patients with Knee Osteoarthritis: Findings from a Randomized Double-Blind Placebo-Controlled Trial

Rahimnia, Alireza; Panahi, Yunes; Alishiri, Gholam Hossein; Sharafi, Mojtaba; Sahebkar, Amirhossein

doi:10.1055/s-0034-1384536

Cited by 68 publications

(66 citation statements)

References 36 publications

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“…In this research, no major toxicity was reported but hypertension and tachycardia were reported in one person and also redness of tongue was observed in another person (Nakagawa et al, ). In other clinical research projects, no major toxicity was reported in patients with osteoarthritis who treated with 1,500 mg/day of curcuminoids orally for 6 weeks and patients who received 1.5 g/day curcumin within 6 weeks (Panahi, Rahimnia, et al, ; Rahimnia, Panahi, Alishiri, Sharafi, & Sahebkar, ). There were no severe adverse events in prediabetic individuals who received 1.5 g/day curcumin for 3 months, but itching was reported in one patient and constipation was observed in two patients (Chuengsamarn, Rattanamongkolgul, Luechapudiporn, Phisalaphong, & Jirawatnotai, ).…”

Section: Resultsmentioning

confidence: 96%

Turmeric (Curcuma longa) and its major constituent (curcumin) as nontoxic and safe substances: Review

Soleimani

Sahebkar

Hosseinzadeh

2018

Phytotherapy Research

441

274

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Curcumin is the major constituent of turmeric (Curcuma longa). Turmeric has been widely used as a spice in foods and for therapeutic applications such as anti-inflammatory, antihyperlipidemic, and antimicrobial activities. Turmeric and curcumin are nonmutagenic and nongenotoxic. Oral use of turmeric and curcumin did not have reproductive toxicity in animals at certain doses. Studies on human did not show toxic effects, and curcumin was safe at the dose of 6 g/day orally for 4-7 weeks. However, some adverse effects such as gastrointestinal upsets may occur. Moreover, oral bioavailable formulations of curcumin were safe for human at the dose of 500 mg two times in a day for 30 days, but there are still few trials and more studies are needed specially on nanoformulations and it should be discussed in a separate article. In addition, curcumin is known as a generally recognized as safe substance. This review discusses the safety and toxicity of turmeric and curcumin in medicine. Turmeric and curcumin are nontoxic for human especially in oral administration. Turmeric and curcumin are also safe in animals. They are nonmutagenic and are safe in pregnancy in animals but more studies in human are needed.

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Section: Resultsmentioning

confidence: 96%

Turmeric (Curcuma longa) and its major constituent (curcumin) as nontoxic and safe substances: Review

Soleimani

Sahebkar

Hosseinzadeh

2018

Phytotherapy Research

441

274

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“…In another study, administration of two capsules containing curcumin 150 mg twice daily by patients with T2DM for 8 weeks significantly decreased CRP, IL‐6, and TNF‐α levels (Usharani et al, ). Also, following 1,500 mg/day curcuminoid ingestion for 6 weeks Rahimnia, Panahi, Alishiri, Sharafi, and Sahebkar () showed significant reduction in circulating levels of IL‐6 and hs‐CRP, and not serum levels of TNF‐α. However, discrepant results in other studies showed that, for example, consuming curcuminoids (1 g/day) for 30 days by obese patients did not change CRP levels (Mohammadi et al, ).…”

Section: Discussionmentioning

confidence: 97%

The effects of curcumin‐containing supplements on biomarkers of inflammation and oxidative stress: A systematic review and meta‐analysis of randomized controlled trials

Tabrizi

Vakili

Akbari

et al. 2018

Phytotherapy Research

124

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Besides other benefits, curcumin is getting more recognized for its antioxidant and anti-inflammatory properties, highlighting the importance of curcumin application for chronic disease prevention. This systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to assess the influence of curcumincontaining supplements on biomarkers of inflammation and oxidative stress. MEDLINE, EMBASE, Web of Science, and Cochrane Central Register of ControlledTrials were searched till January 2018 for eligible studies. The selected studies were evaluated for their quality using the Cochrane risk of bias tool and relevant data were extracted from included studies. Data were pooled using the inverse variance method and expressed as standardized mean difference (SMD) with 95% confidence intervals (95% CI). Fifteen RCTs were included in the final analysis. The meta-analysis indicated that curcumin supplementation significantly decreased interleukin 6 (IL-6) (SMD −2.08; 95% CI [−3.90, −0.25]; p = 0.02), high-sensitivity C-reactive protein (hs-CRP) (SMD −0.65; 95% CI [−1.20, −0.10], p = 0.02), and malondialdehyde (MDA) concentrations (SMD −3.14; 95% CI [-4.76, −1.53], p < 0.001). Though, curcumin supplementation had no significant effect on tumor necrosis factor-alpha (SMD −1.62; 95% CI [−3.60, 0.36]; p = 0.10) and superoxide dismutase levels (SMD 0.34; 95% CI [−1.06, 1.74], p = 0.63). Overall, this meta-analysis suggests that taking curcumin-containing supplements may exert anti-inflammatory and antioxidant properties through a significant reduction in IL-6, hs-CRP, and MDA levels.

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“…A key mechanism for the modulatory effects of curcumin on pro inflammatory cytokines is the suppression of NF-κB ( (Banerjee, Tripathi, Srivastava, Puri, & Shukla, 2003;Clutterbuck et al, 2009;Davis et al, 2007;Jagetia & Aggarwal, 2007;Mathy-Hartert et al, 2009;Rahimnia et al, 2015). The effects of curcumin on the production of key cytokines and chemokines is shown in Table 1.…”

Section: The Effects Of Curcumin On Cytokine Production and Inflammmentioning

confidence: 99%

Therapeutic effects of curcumin in inflammatory and immune‐mediated diseases: A nature‐made jack‐of‐all‐trades?

Abdollahi

Momtazi

Johnston

et al. 2017

Journal Cellular Physiology

230

118

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Curcumin is a dietary polyphenol from turmeric with numerous pharmacological activities. Novel animal and human studies indicate that curcumin can affect different immune cells, such as various T lymphocyte subsets, macrophages, dendritic cells, B lymphocytes and natural killer cells, which results in decreasing severity of various diseases with immunological etiology. The present review provides a comprehensive overview of the effects of curcumin on different immune cells and immune system-related diseases.

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Impact of Supplementation with Curcuminoids on Systemic Inflammation in Patients with Knee Osteoarthritis: Findings from a Randomized Double-Blind Placebo-Controlled Trial

Abstract: Significant improvement in clinical symptoms of OA in curcuminoid-treated subjects cannot be attributed to the systemic anti-inflammatory effects of these phytochemicals.

Cited by 68 publications

References 36 publications

Turmeric (Curcuma longa) and its major constituent (curcumin) as nontoxic and safe substances: Review

Turmeric (Curcuma longa) and its major constituent (curcumin) as nontoxic and safe substances: Review

The effects of curcumin‐containing supplements on biomarkers of inflammation and oxidative stress: A systematic review and meta‐analysis of randomized controlled trials

Therapeutic effects of curcumin in inflammatory and immune‐mediated diseases: A nature‐made jack‐of‐all‐trades?

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