Impact of Supplementing Preoperative Intravenous Omega 3 Fatty Acids in Fish Oil on Immunomodulation in Elderly Patients Undergoing Hip Surgery

Ramachandran, Gurumurthy; Yelliboina, Sreekanth; Singh, Meenakshi; Prasad, V. S. S. V.

doi:10.1007/s12262-012-0543-3

Cited by 3 publications

(3 citation statements)

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“…The level of evidence for an anti-inflammatory effect of n -3 PUFA supplementation in older individuals is perhaps more solid, as shown in Table 2 . In two RCTs carried out on older individuals undergoing hip surgery [ 96 ] or admitted to ICU with critical illness [ 97 ], the intravenous administration of fish oil-based lipid emulsions for eight days was effective to increase the circulating levels of the anti-inflammatory cytokine IL-10. A decrease in serum levels of IL-8, TNF-α and IL-6 levels was also observed [ 96 , 97 ].…”

Section: N -3 Polyunsaturated Fatty Acids and Imentioning

confidence: 99%

“…In two RCTs carried out on older individuals undergoing hip surgery [ 96 ] or admitted to ICU with critical illness [ 97 ], the intravenous administration of fish oil-based lipid emulsions for eight days was effective to increase the circulating levels of the anti-inflammatory cytokine IL-10. A decrease in serum levels of IL-8, TNF-α and IL-6 levels was also observed [ 96 , 97 ]. Interestingly, Berger et al , in a RCT enrolling both adult and geriatric patients undergoing cardiopulmonary bypass surgery, showed that n -3 PUFA decreased the perioperative inflammation [ 98 ].…”

Section: N -3 Polyunsaturated Fatty Acids and Imentioning

confidence: 99%

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Nutrition and Inflammation in Older Individuals: Focus on Vitamin D, n-3 Polyunsaturated Fatty Acids and Whey Proteins

et al. 2016

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Chronic activation of the inflammatory response, defined as inflammaging, is the key physio-pathological substrate for anabolic resistance, sarcopenia and frailty in older individuals. Nutrients can theoretically modulate this phenomenon. The underlying molecular mechanisms reducing the synthesis of pro-inflammatory mediators have been elucidated, particularly for vitamin D, n-3 polyunsaturated fatty acids (PUFA) and whey proteins. In this paper, we review the current evidence emerging from observational and intervention studies, performed in older individuals, either community-dwelling or hospitalized with acute disease, and evaluating the effects of intake of vitamin D, n-3 PUFA and whey proteins on inflammatory markers, such as C-Reactive Protein (CRP), interleukin-1 (IL-1), interleukin-6 (IL-6) and tumor necrosis factor α (TNF-α). After the analysis, we conclude that there is sufficient evidence for an anti-inflammatory effect in aging only for n-3 PUFA intake, while the few existing intervention studies do not support a similar activity for vitamin D and whey supplements. There is need in the future of large, high-quality studies testing the effects of combined dietary interventions including the above mentioned nutrients on inflammation and health-related outcomes.

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Section: N -3 Polyunsaturated Fatty Acids and Imentioning

confidence: 99%

Section: N -3 Polyunsaturated Fatty Acids and Imentioning

confidence: 99%

Nutrition and Inflammation in Older Individuals: Focus on Vitamin D, n-3 Polyunsaturated Fatty Acids and Whey Proteins

et al. 2016

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“…Moreover, their synthesis is extremely limited in most mammals (less than 5% of the precursors are converted) [16]. Increasing data in animal models as well as in humans suggest that dietary PUFA exert immunomodulatory effects [17][18][19][20]. Indeed, n-3 long chain PUFAs form the basis of lipid derivatives (neuroprotectins and resolvins) with anti-inflammatory properties [21][22][23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%

N-3 polyunsaturated fatty acid and neuroinflammation in aging and Alzheimer’s disease

Layé

Madore

St‐Amour

et al. 2015

NUA

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The innate immune system of the brain is mainly composed of microglial cells, which play a key role in the maintenance of synapses and the protection of neurons against noxious agents or lesions owing to their phagocytic activity. In the healthy brain, microglia are highly motile and strongly interact with neurons either by physical contact, induction of oxidative stress or through specific mediators, such as chemokines and cytokines. In response to inflammatory insult however, microglial cells get activated and produce inflammatory cytokines. The action of cytokines on specific receptors expressed in the brain triggers the development of sickness behavior and altered cognitive and emotional processes. The effects are acute and reversible as normal behavior is restored once the synthesis of inflammatory brain cytokines returns to baseline after a few hours. However, in pathological situations, these cytokines may reach toxic levels and have irreversible consequences such as neuronal death, as observed in neurodegenerative disorders such as Alzheimer's disease. Omega-3 (n-3) polyunsaturated fatty acids (PUFAs) are essential nutrients and fundamental components of neuronal and glial cell membranes. They accumulate in the brain during the perinatal period in a dietary supply-dependent fashion. Their brain levels may diminish with age, but can be increased by diets enriched in n-3 PUFAs. Changes in the immune profile have been associated with n-3 PUFAs intake in humans and animal models. Therefore, the increasing exposure of the population to diets low in n-3 PUFAs could contribute to the deleterious effects of the chronic activation of microglia in the brain.

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Habitual dietary fat intake and risk of muscle weakness and lower-extremity functional impairment in older adults: A prospective cohort study

et al. 2020

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Impact of Supplementing Preoperative Intravenous Omega 3 Fatty Acids in Fish Oil on Immunomodulation in Elderly Patients Undergoing Hip Surgery

Abstract: The aim of this study was to evaluate the immu-

Cited by 3 publications

References 25 publications

Nutrition and Inflammation in Older Individuals: Focus on Vitamin D, n-3 Polyunsaturated Fatty Acids and Whey Proteins

Nutrition and Inflammation in Older Individuals: Focus on Vitamin D, n-3 Polyunsaturated Fatty Acids and Whey Proteins

N-3 polyunsaturated fatty acid and neuroinflammation in aging and Alzheimer’s disease

Habitual dietary fat intake and risk of muscle weakness and lower-extremity functional impairment in older adults: A prospective cohort study

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