Impact of the ferrocenyl group on cytotoxicity and KSP inhibitory activity of ferrocenyl monastrol conjugates

Abstract

Introduction of the ferrocenyl group into the monastrol scaffold improved the cytotoxic activity, and increased the kinesin-spindle-protein (KSP) inhibitory activity and its ability to generate ROS which led to increased levels of apoptotic cells.

Os(ii) complexes for catalytic anticancer therapy: recent update

“…In this feature article, we have outlined the potential of 16/18 electron Os(II) complexes for cancer treatment. The 16 electron complexes (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(16)(17)(18) behaved as efficient catalysts to achieve the transfer hydrogenation of pyruvate or quinones in the presence of a suitable hydride donor. Pyruvate is known for its active involvement in ATP production.…”

“…Many metal complexes have been reported for incell catalytic reactive oxygen species (ROS) generation. [9][10][11][12][17][18][19][20][21][22] The generated ROS are found to kill cancer cells by oxidative stress. Besides their anticancer activity, metal complexes also have significant catalytic applications in various industrial syntheses.…”

“…Fig.9(a) The organo-Os(II) complexes(16)(17)(18) for efficient catalytic quinone reduction 50. (b) Bar diagram showing the TOFs of 1, 16-18 for quinone reduction 50.…”

Organometallic Ru, Os, Rh and Ir half-sandwich conjugates of ispinesib – impact of the organometallic group on the antimitotic activity

“…48 Also, conjugating a ferrocenyl moiety with monastrol positively impacted the cytotoxicity and KSP inhibitory activity. 49 Continuing our research on antimitotic organometallic compounds, [50][51][52][53] we investigated the effect of combining into one molecule the well-known KSP inhibitor ispinesib with half-sandwich complexes on the biological activity, ideally resulting in synergistic activity.…”

“…48 Also, conjugating a ferrocenyl moiety with monastrol positively impacted the cytotoxicity and KSP inhibitory activity. 49…”