Impact of the hepatitis B virus genotype and genotype mixtures on the course of liver disease in Vietnam†

Toàn, Nguyễn Lĩnh; Song, Lê Hữu; Kremsner, Peter G.; Duy, Dinh N.; Binh, Vu Q.; Koeberlein, Bernd; Kaiser, Stefan; Kandolf, Reinhard; Torresi, Joseph; Bock, C.‐Thomas

doi:10.1002/hep.21188

Cited by 103 publications

(113 citation statements)

References 37 publications

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“…Despite the apparent low prevalence of HBV/G throughout the world, the viral genotype appears to circulate globally, as it has been reported in several European countries (De Maddalena et al, 2007;Jardi et al, 2008;Lacombe et al, 2006;Tran et al, 1991;Vieth et al, 2002), North and South America (Alvarado-Esquivel et al, 2006;Bottecchia et al, 2008;Kato et al, 2004;Osiowy & Giles., 2003;Sánchez et al, 2007), Nigeria (Olinger et al, 2006) and Asia (Shibayama et al, 2005;Suwannakarn et al, 2005;Toan et al, 2006). Canadian HBV/G was highly associated with MSM as a risk factor for infection, corresponding to previous studies (Bottecchia et al, 2008;Shibayama et al, 2005;Sánchez et al, 2007).…”

mentioning

confidence: 52%

Hepatitis B virus genotype G epidemiology and co-infection with genotype A in Canada

Osiowy

Gordon²,

Borlang³

et al. 2008

Journal of General Virology

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Hepatitis B virus (HBV) genotype G (HBV/G) is an unusual variant, and little is known about its epidemiology and natural history, particularly the requirement for a co-infecting HBV genotype and their relationship during infection. This study investigated the quasispecies nature of coinfecting genotypes in 39 samples collected over a 6 year period from 13 HBV/G-infected patients. HBV/G infections were found to occur predominantly in males (92 %) and were primarily associated with male homosexual sex (67 %). All patients were infected with HBV/G and HBV/A, or a recombinant HBV/A/G strain. Co-infecting genotypic prevalence was often observed to fluctuate over time, with periods of HBV/G monoinfection in some patients. The average sequence divergence among Canadian HBV/G strains was 1.57±0.62 %. Thus, all HBV/G infections in Canada occur in the context of co-infection or recombination with HBV/A, and strains display increased sequence divergence compared with all known HBV/G sequences described to date.

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mentioning

confidence: 52%

Hepatitis B virus genotype G epidemiology and co-infection with genotype A in Canada

Osiowy

Gordon²,

Borlang³

et al. 2008

Journal of General Virology

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“…Among the studies of the HBV genotype in Vietnamese, that of Lindh et al suggested that genotype A was present (17), but Hannoun et al later analyzed those HBV strains in more detail and concluded that it was not certain that genotype A was present (29). To the best of our knowledge, the HBV genotype A in Vietnamese was previously reported in only four patients: three of them were originally from Southern Vietnam (30) and the other was a Vietnamese immigrant in the United States (31); and most recently one study reported that HBV genotypes from A to G were detected in Vietnamese but the prevalence of genotype A was only approximately 18% (32). In contrast to the findings of the above studies in Vietnamese, a study by Song et al reported that genotype A was very commonly observed in HBV-infected Vietnamese patients (98.7%), that the pre-core mutation (G1896A) was not found, and dual core promoter mutations (A1762T/G1764A) were very rare in HCC patients (8%) and were not found in LC patients, CH patients or asymptomatic carriers (ASC) (33).…”

Section: Introductionmentioning

confidence: 92%

Genotype and variations in core promoter and pre-core regions are related to progression of disease in HBV-infected patients from Northern Vietnam

Truong

Seo²,

Yano³

et al. 2007

Int J Mol Med

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Abstract.Vietnam is one of the countries with a high rate of hepatitis B virus (HBV) infection, but there are only a few reports about relation of HBV genotypes and mutations to clinical course in Northern Vietnam. The characteristics of HBV and its relationship to clinical outcome in patients from Northern Vietnam were analyzed. Serum samples were collected from 183 HBV-infected Vietnamese patients. They were clinically categorized into 4 groups: hepatocellular carcinoma (HCC), liver cirrhosis (LC), chronic hepatitis (CH), and asymptomatic carriers (ASC). HBV serology, ·-fetoprotein, HBV genotypes, HBV-DNA level and mutations in the core promoter and pre-core regions of HBV-DNA were examined. The majority of sera contained HBV genotype B (67.8%) and C (27.9%). The median age was matched between genotype B and C (38.2 vs. 42.9 years). The rates of HBeAg seroconversion and G1896A for genotype B were significantly higher than those for genotype C (P<0.05). Genotype C had a higher HBV-DNA level than genotype B. C1858 was frequent, especially in genotype C (62.7%). The most prevalent genotype in ASC and CH was genotype B. The presence of the mutation A1762T/G1764A correlated with disease progression. The triple mutation T1753C/A1762T/ G1764A was quite common and was more prevalent in LC and HCC than in CH and ASC. In Northern Vietnamese, HBV genotypes B and C were prevalent. Genotype C and mutations in the core promoter region were associated with progressive, severe liver diseases.

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“…Genotypes/subgenotypes have distinct geographical distributions: HBV/A and HBV/D are found worldwide, HBV/B and HBV/C are found in east/south-east Asia, HBV/E in west/central Africa, and HBV/F and HBV/H in native populations of the Americas (Araujo et al, 2011; Kramvis et al, 2005). HBV/G was described by Stuyver et al (2000) and, despite low prevalence, seems ubiquitous, as it has been reported in Europe (Lacombe et al, 2006;Vieth et al, 2002), the Americas (Alvarado-Esquivel et al, 2006;Alvarado Mora et al, 2011;Bottecchia et al, 2008;Chu et al, 2003;Osiowy et al, 2008), Asia (Shibayama et al, 2005;Toan et al, 2006) and Africa (Olinger et al, 2006;Toan et al, 2006). HBV/G is frequently reported in patients infected with human immunodeficiency virus (HIV) (Dao et al, 2011;Zehender et al, 2003), particularly in men who have sex with men (MSM) (Bottecchia et al, 2008;Osiowy et al, 2008).…”

mentioning

confidence: 97%

Identification of novel recombinants of hepatitis B virus genotypes F and G in human immunodeficiency virus-positive patients from Argentina and Brazil

Araújo

Araujo

Silva

et al. 2013

Journal of General Virology

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in both patients, with .99 % of colonies hybridizing to a probe specific for this insertion. Phylogenetic analyses of full-length genomes and precore/core fragments revealed that F4 and F1b were the co-infecting subgenotypes in the Brazilian and Argentinian patients, respectively. Bootscanning analysis provided evidence of recombination in several clones from both patients, with recombination breakpoints located mainly at the precore/core region. These data should encourage further investigations on the clinical implications of HBV/G recombinants in HBV/HIV co-infected patients.

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Impact of the hepatitis B virus genotype and genotype mixtures on the course of liver disease in Vietnam†

Cited by 103 publications

References 37 publications

Hepatitis B virus genotype G epidemiology and co-infection with genotype A in Canada

Hepatitis B virus genotype G epidemiology and co-infection with genotype A in Canada

Genotype and variations in core promoter and pre-core regions are related to progression of disease in HBV-infected patients from Northern Vietnam

Identification of novel recombinants of hepatitis B virus genotypes F and G in human immunodeficiency virus-positive patients from Argentina and Brazil

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