Impact of the Novel Influenza A (H1N1) during the 2009 Autumn‐Winter Season in a Large Hospital Setting in Santiago, Chile

Torres, Juan Pablo; O’Ryan, Miguel; Hervé, Beatrice; Espinoza, Ricardo; Acuña, Guillermo; Mañalich, Jaime; Chomali, May

doi:10.1086/650750

Cited by 59 publications

(64 citation statements)

References 12 publications

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“…Torres et al 15 described a frequency of 45% of H1N1 2009 among Chilean young adults (5-18 years). Echavarria et al 16 described that 43% of H1N1 2009 infected patients in Argentina were part of the 5-18 years age group.…”

Section: Ethical Considerationsmentioning

confidence: 99%

Surveillance of influenza A H1N1 2009 among school children during 2009 and 2010 in São Paulo, Brazil

Guatura

Watanabe

Camargo

et al. 2012

Rev. Soc. Bras. Med. Trop.

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Introduction: Influenza A H1N1 2009 is associated with a high morbidity rate among children around the world, including Brazil. This survey was conducted on samples of symptomatic children (≤ 12 years) to investigate the influenza virus as the etiological agent of respiratory infections in a day care school in a health facility during the first and second pandemic wave of H1N1 (2009)(2010) in São Paulo, Brazil. Methods: Influenza infections were determined by real-time PCR in 34% (47/137) of children with a median age of 5 years (8 months -12 years), from June to October 2009 and in 16% (14/85) of those with median age of 6 years (1-12 years), from March to November 2010. Results: In general, most positive cases (64%) occurred in children aged 5-12 years, this age group was significantly the most affected (39.8%, p = 0.001, OR = 8.3, CI 95% 1.9-36.9). Wheezing was reported by 31% (19/61) and dyspnea by 23% (14/61) of the studied patients. An outbreak of influenza H1N1 with an attack rate of 35.7% among children (median age 6 years) was documented in April 2010, before the vaccination campaign against the pandemic virus was extended for children up to 5 years in Brazil. Conclusions: Therefore, the study reinforces the recommendation to immunize school children to reduce the incidence of the disease.

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Section: Ethical Considerationsmentioning

confidence: 99%

Surveillance of influenza A H1N1 2009 among school children during 2009 and 2010 in São Paulo, Brazil

Guatura

Watanabe

Camargo

et al. 2012

Rev. Soc. Bras. Med. Trop.

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“…Although various antigen detection kits available in the market can differentiate between seasonal influenza A and B types, they are unable to detect the pH1N1 virus exclusively. Although a rapid diagnostic method may help in early initiation of empirical therapy but treatment, based on clinical conditions, should not be withheld on negative results [32]. The recent pandemic was realization of the fact that rapid tests are not so accurate and there is a need for alternatives to the costly molecular techniques like real-time PCR assays.…”

Section: Rapid Diagnostic Tests Can't Be Used For Accurate Detection mentioning

confidence: 99%

Pandemic Influenza A H1N1 (2009) Virus: Lessons from the Past and Implications for the Future

et al. 2012

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The recent pandemic by novel influenza A (H1N1) 2009 (pH1N1) virus is an emerging viral infection, being of significant international concern and requires intensive research. The virus spread in pandemic proportions, and continues to be in the post-pandemic phase. Since, the pH1N1 is still circulating in the community, monitoring is required during the post-pandemic period. The pH1N1 defied influenza seasonality and rapidly became dominant over the seasonal influenza viruses. This new strain was antigenically different from the seasonal H1N1 influenza strains due to the genetic re-assortment. Surprisingly, this new reassortant virus emerged at the end of influenza season, caused a sudden toll of mild illness and is now co-circulating with the seasonal strains. The recent outbreak of pH1N1 consolidates the fact that a new reassortant virus may have originated in animal reservoirs and got transferred to human who were in close contact with these animals. There is a continued need for multisite surveillance to detect potentially dangerous influenza strains, which may emerge and establish themselves in human population. This review is an attempt to address the lessons learnt from the recent influenza pandemic and the future implications for prevention and control of influenza.

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“…Su llegada a Chile se registró a fines de abril del mismo año 2 y durante los primeros cuatro meses se notificaron 340.000 casos de enfermedad tipo influenza, una tasa de ataque de 1,2% de la población, 1.585 hospitalizaciones y 130 fallecidos 3 . La experiencia nacional publicada hasta ahora ha sido escasa y restringida a pacientes atendidos en instituciones privadas de la Región Metropolitana (RM) 4,5 o en el extremo sur del país 2,6 . Además, la información disponible sobre la carga económica asociada a las hospitalizaciones por esta enfermedad a nivel mundial es muy escasa e inexistente en Chile, lo que tiene relevancia en la adopción o evaluación de políticas preventivas.…”

Section: Morbidity and Mortality Associated To Influenza A (H1n1) 200unclassified

“…Además, 16% de los pacientes presentó hipotensión arterial al ingreso, un elemento clínico no asignado históricamente a pacientes con infección pulmonar de origen viral, excepto en el caso de pacientes con infección por hantavirus 12 . El shock hemodinámico fue detectado en 3 de 99 pacientes (~3%) que ingresaron a una clínica privada de la RM el primer año de la pandemia 5 , en 20% de 20 hospitalizados en el sur de Chile y en grandes series de pacientes con influenza A (H1N1) 2009 se han reportado cifras de shock hemodinámico entre 1,7 y 8,8% de la población bajo estudio 2,13,14 . Ello genera imperfecciones del sistema de puntuación CURB-65 para reconocer casos graves por influenza.…”

Section: Características Clínicas Sistemas De Puntuación Y Laboratoriounclassified

“…La proporción de pacientes que ingresa a UCI ha sido variable en la literatura médica con rangos de 22,6 a 43% 14,17 y de 12,8 a 27,7% para conexión a VM 11,14 . No obstante esta dispersión, las tasas de letalidad hospitalaria observadas en este trabajo (16%) están en línea con lo reportado por otros autores (15 a 17%) 11,17 pero difieren con la ausencia de casos letales observados en dos clínicas privadas en la RM de Chile 4,5 , lo que en al menos un caso es explicado por el bajo perfil de co-morbilidad y gravedad incluido en la serie 5 .…”

Section: Características Clínicas Sistemas De Puntuación Y Laboratoriounclassified

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Morbilidad y mortalidad asociada a hospitalizaciones por influenza pandémica A (H1N1) 2009 en dos hospitales de la Región Metropolitana y evaluación de su impacto económico

Armstrong

Fíca

Dabanch

et al. 2012

Rev. chil. infectol.

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Impact of the Novel Influenza A (H1N1) during the 2009 Autumn‐Winter Season in a Large Hospital Setting in Santiago, Chile

Cited by 59 publications

References 12 publications

Surveillance of influenza A H1N1 2009 among school children during 2009 and 2010 in São Paulo, Brazil

Surveillance of influenza A H1N1 2009 among school children during 2009 and 2010 in São Paulo, Brazil

Pandemic Influenza A H1N1 (2009) Virus: Lessons from the Past and Implications for the Future

Morbilidad y mortalidad asociada a hospitalizaciones por influenza pandémica A (H1N1) 2009 en dos hospitales de la Región Metropolitana y evaluación de su impacto económico

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