Impact of tubal ligation on ovarian reserve as measured by anti-Müllerian hormone levels: a prospective cohort study

Silva, Ana Luiza Berwanger da; Ré, Camila da; Dietrich, Cristine; Fuhrmeister, Isabela Piva; Pimentel, Ana Laura; Corleta, Helena von Eye

doi:10.1016/j.contraception.2012.09.021

Cited by 17 publications

(21 citation statements)

References 44 publications

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“…There were no differences between preoperative and 3-month postoperative measurements with median AMH (1.5 vs. 1.4; p = 0.07), AFC (8.4 ± 3.7 vs. 7.9 ± 4.1; p = 0.09), FSH (7.6 ± 2.1 vs. 7.7 ± 2.1; p = 0.10). Silva et al assessed the effect of tubal ligation ( n = 52) in longer term postoperative period (1 year) and reported that median AMH (1.43, IQR 0.63–2.62 vs. 1.30, IQR 0.53–2.85; p = 0.23) and mean AFC (8, IQR 5–14 vs. 11, IQR 7–15; p = 0.12) did not change significantly [ 7 ]. Thus, our results along with other published evidence suggest that salpingectomy or tubal division does not have an adverse effect on ovarian reserve.…”

Section: Discussionmentioning

confidence: 99%

Effect of salpingectomy, ovarian cystectomy and unilateral salpingo-oopherectomy on ovarian reserve

et al. 2016

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Pelvic surgery can affect ovarian reserve, but estimates of the potential effect of different surgical procedures are lacking. This study examines the markers of ovarian reserve after different procedures in order to help the provision of informed consent before surgery. Anti-Müllerian hormone (AMH), antral follicle count (AFC) and follicle-stimulating hormone (FSH) of women with a history of salpingectomy, ovarian cystectomy or unilateral salpingo-oophorectomy were compared to those without history of surgery using cross-sectional data adjusting for patient and clinical factors in multivariable regression model. There were 138 women who had had salpingectomy, 36 unilateral salpingo-oopherectomy, 41 cystectomy for ovarian cysts that are other than endometrioma and 40 women had had excision of endometrioma. There was no significant difference in AMH (9 %; p = 0.33), AFC (−2 %; p = 0.59) or FSH (−14 %; p = 0.21) in women with a history of salpingectomy compared to women without surgery. Women with a history of unilateral salpingo-oophorectomy were found to have significantly lower AMH (−54 %; p = 0.001). These women also had lower AFC (−28 %; p = 0.34) and higher FSH (14 %; p = 0.06), the effect of which did not reach statistical significance. The study did not find any significant associations between a history of cystectomy, for disease other than endometrioma and AMH (7 %; p = 0.62), AFC (13 %; p = 0.18) or FSH. (11 %; p = 0.16). Women with a history of cystectomy for ovarian endometrioma had 66 % lower AMH (p = 0.002). Surgery for endometrioma did not significantly affect AFC (14 %; p = 0.22) or FSH (10 %; p = 0.28). Salpingo-oopherectomy and cystectomy for endometrioma cause a significant reduction in AMH levels. Neither salpingectomy nor cystectomy for cysts other than endometrioma has appreciable effects on ovarian reserve.Electronic supplementary materialThe online version of this article (doi:10.1007/s10397-016-0940-x) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Effect of salpingectomy, ovarian cystectomy and unilateral salpingo-oopherectomy on ovarian reserve

et al. 2016

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“…Sequential assessments of serum AMH levels did not reveal statistically significant differences before and after laparoscopic coagulation and dissection of the proximal tubes (1.548 ng/mL preoperatively vs. 1.481 ng/mL 3 months after surgery, median; P = 0.079) [ 49 ]. Similarly, research illustrated that serum AMH levels were not affected by tubal ligation (1.43 ng/mL preoperatively vs. 1.30 ng/mL 12 months after surgery, median; P = 0.23) [ 50 ].…”

Section: Resultsmentioning

confidence: 99%

Assessment of ovarian reserve using anti-Müllerian hormone levels in benign gynecologic conditions and surgical interventions: a systematic narrative review

Iwase

Nakamura

Nakahara

et al. 2014

Reprod Biol Endocrinol

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The usefulness of anti-Müllerian hormone (AMH) for the quantitative evaluation of ovarian reserve has been established. Therefore, serum AMH has been recently applied to the assessment of ovarian reserve outside infertility treatment. We conducted a computer-based search, using keywords, through the PubMed database from inception until May 2014 and summarized available studies evaluating ovarian damage caused by gynecologic diseases, such as endometriosis and ovarian tumor, as well as surgical interventions, such as cystectomy and uterine artery embolization (UAE), to discuss the usefulness of serum AMH. Most of the studies demonstrated a decline of serum AMH levels after cystectomy for endometriomas. It is not conclusive whether electrocoagulation or suturing is preferable. The effects of other gynecologic diseases and interventions, such as hysterectomy and UAE, on ovarian reserve are controversial. Serum AMH levels should be considered in determining the indication and selection of operative methods for benign gynecologic conditions.

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“…Researchers report a variable degree of feasibility, perioperative surgical consequences and this could be explained based on heterogeneity in surgical experiences as well as surgical techniques and surgical instruments. Studies evaluating ovarian reserve impacts of tubal sterilization did not show determinant changes on either hormonal or stromal blood supply [33,34] . Also, pilot RCT comparing 46 parturients (32 women of them completed the trial follow up, 16 in BTS arm and 18 BPS (STL)) found that AMH prior to CS as well as at 6 -8 weeks postpartum and the increase in AMH didn't differs significantly between both group (ΔAMH were increase of 0.58 ± 0.98 in (BTS) vs. 0.39 ± 0.41 in (BPS) ng/ml, p=0.45) [23] .…”

Section: Discussionmentioning

confidence: 99%

Impact of bilateral total salpingectomy versus standard tubal ligation at time of cesarean section on ovarian reserve: A randomized controlled trial

Elnory

Elmantwe

2019

Evidence Based Women's Health Journal

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Aim of the work: The objective of this trial was to compare between bilateral total salpingectomy (BTS) as a theoretically more effective ovarian cancer (OvCa) risk-reducing primary prevention and bilateral partial salpingectomy (BPS) [stander tubal ligation (STL)] procedures at time of cesarean section (CS) for parturients who completed their reproductive desire and requesting permanent sterilization regard to the impacts of both procedures on ovarian reserve parameters at one year post-sterilization as well as the surgical consequences of both procedures. Patients and Methods: This is a prospective, randomized, open-label, concealed allocation, parallel group, superiority trial was conducted at three surgical sites in El-Qulobia, Egypt including Benha University Hospital, Obstetrics and Gynecology Department between October 2015 and October 2017. 120 parturients undergoing CS were allocated to BTS (intervention group) (60) and BPS (control group) (60). Main outcomes were one year post-sterilization differences in ovarian reserve (OR) parameters including hormonal as well as two-dimensional and three-dimensional transvaginal ultrasonographic parameters ; namely, anti-müllerian hormone (AMH) (ng/ml), follicular stimulating hormone (FSH) (mIu/ml), peak systolic velocity (PSV) (cm/s), antral follicle count (AFC) (n), vascular index (VI) (%), flow index (FI) (0-100), vascular flow index (VFI) (0-100), calculated ovarian age [OvAge (year)] and ovarian volume. Ancillary outcomes were surgical feasibility and surgical consequences. Results: 102 women completed the one-year follow up (85%), 50 in the BTS group and 52 in the BPS group and there were no statistically significant differences regarding the ovarian reserve parameters at one year post-sterilization including AMH, FSH, AFC, VI, FI, VFI OvAge and ovarian volume (P > 0.05). Also, there were no statistically significant differences regarding items included in surgical. consequences comparison (P > 0.05) as well as surgical sterilization feasibility (100% vs 100%, p = 1). Also, there were no apparent complications due to sterilization procedures in both groups. Conclusion: Impacts of bilateral total salpingectomies (BTS) on ovarian reserve as sterilizing procedure during cesarean section as well as rates of surgical consequences are similar with that of bilateral partial salpingectomies (BPS) (STL). So, BTS could be recommended over BPS (STL) for women completing their reproductive desire, despite its better efficacy as ovarian cancer reducing surgery as well as its better clinical and sterilizing efficacy remained to be elucidated. .

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Impact of tubal ligation on ovarian reserve as measured by anti-Müllerian hormone levels: a prospective cohort study

Cited by 17 publications

References 44 publications

Effect of salpingectomy, ovarian cystectomy and unilateral salpingo-oopherectomy on ovarian reserve

Effect of salpingectomy, ovarian cystectomy and unilateral salpingo-oopherectomy on ovarian reserve

Assessment of ovarian reserve using anti-Müllerian hormone levels in benign gynecologic conditions and surgical interventions: a systematic narrative review

Impact of bilateral total salpingectomy versus standard tubal ligation at time of cesarean section on ovarian reserve: A randomized controlled trial

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