Impact of Two Types of Exercise Interventions on Leptin and Omentin Concentrations and Indicators of Lipid and Carbohydrate Metabolism in Males with Metabolic Syndrome

Abstract

Leptin (LEP) and omentin (OMEN) are proteins whose concentrations change with the development of the metabolic syndrome (MetS). There are few intervention studies using various forms of physical activity in people with MetS that aim to determine the impact of physical exercise on the fluctuations of the presented hormones, and their results are contradictory. The present study aimed to examine the effect of two types of exercise intervention on LEP and OMEN concentrations and indicators of lipid and carbohydrate metabolism in males with MetS. The study included 62 males with MetS (age 36.6 ± 6.9 years, body mass 110.31 ± 17.37 kg), randomly allocated to EG1, the examined group with aerobic training (n = 21); EG2, the examined group with combined aerobic and resistance training (n = 21), both for 12 weeks, and the control group (CG) without interventions (n = 20). Anthropometric measurements, body composition (body fat [BF], android body fat [ANDR]), as well as a biochemical blood analysis (omentin [OMEN], leptin [LEP], quantitative insulin sensitivity check index [QUICKI], high-density lipoprotein cholesterol [HDL-C] and nonHDL-C) were performed at baseline, and at 6 and 12 weeks of interventions and after 4 weeks after ending intervention (follow-up). Intergroup and intragroup comparisons were performed. In the intervention groups EG1 and EG2, a decrease in BF was observed as well as an improvement in carbohydrate metabolism parameters. In the EG1 group, the level of ANDR was reduced. In EG2 a decrease in LEP concentration between measurements was confirmed. However, no significant changes were found in the concentration of OMEN in any groups. Combined aerobic and resistance exercises led to a higher reduction of LEP concentration than applying only aerobic training in males with MetS.

Exercise-induced effects on asprosin and indices of atherogenicity and insulin resistance in males with metabolic syndrome: a randomized controlled trial

“…The development of muscle mass through aerobic-resistance training maintained body weight at a similar level, despite a reduction in fat tissue. On the other hand, in the group with aerobic intervention, a significant decrease in BMI between measurements reflects a decrease in body weight due to lost fat tissue, as demonstrated in previous paper 35 .…”

“…The study was registered in the Australian New Zealand Clinical Trials Registry under the registration number ACTRN12622001394730 (31/10/2022) and followed CONSORT guidelines. A detailed description of the research methods was presented in previous papers 31 , 34 , 35 .…”

Exercise-Induced Alternations of Adiponectin, Interleukin-8 and Indicators of Carbohydrate Metabolism in Males with Metabolic Syndrome

“…Our results showed that the ADIPO/LEP ratio decreased significantly after 6 weeks of aerobic intervention. The occurring relation resulted from a significant increase of LEP level, presented in our previous work [42] and the lack of significant changes in the level of ADIPO during the analyzed period. LEP can react to the changes taking place in the population of people with MetS faster than ADIPO.…”

“…The study was designed as a randomized, prospective controlled study. A detailed description of the research methods was presented in previous papers [41,42]. The aim of this study was to compare the 12-week effect of two types of physical training on ADIPO and IL-8 levels and carbohydrate metabolism indices in men with metabolic syndrome (MetS), compared to men with MetS not undertaking physical activity (control group CG).…”