Impact of uric acid on incident hypertension: Sex-specific analysis in different age groups

Role of asymptomatic hyperuricemia in the progression of chronic kidney disease and cardiovascular disease

“…In a recent retrospective observational study [104], in Gunma, Japan they studied 12,029 participants to evaluate the association of UA with the risk of HTN among different age and different sex, the results of that study showed that older men had lower UA, whereas older women had higher UA, compared to young age participants. In another recent observational study [105], were done to assess the sex-specific association of SUA with all-cause mortality in 40 years old patients, the study conducted 27,490 participants, the study results showed that a lower SUA was an independent risk factor for all-cause mortality in men than women, also they found out that the SUA levels were lower in women than in men.…”

“…In a recent retrospective observational study in Gunma, Japan [ 96 ], 12,029 participants were enrolled to evaluate the association between UA level and HTN risk according to age and sex. The results showed that older men had lower UA levels, whereas older women had higher UA levels, compared with younger participants.…”

Epidemiological Studies of Uric Acid: A Mini-review with a Focus on Mendelian Randomization

“…Experimental and epidemiological studies on the urate role in asymptomatic atherosclerotic damage (in terms of carotid intima-media thickness, arterial stiffness, endothelial function, and so on), including studies that report negative results, have been reviewed in Cortese et al [2]. Recent epidemiological studies in support of the urate role in hypertension include Kuwabara et al [43], Wang et al [45] and Ohyama et al [44]. However, the directionality of the association remains debated.…”