The coronavirus disease 2019 (COVID-19) pandemic has changed the world, creating the need for new actions from society, including universities and companies. The United Nations Sustainable Development Goals (SDGs) are part of a global agenda, but this priority is not significant to university students. Although some research has focused on SDGs and university students, there is a lack of evaluation and comparison in Latin American countries. The current study aims to evaluate student knowledge of the SDGs, the relation of student professional careers to the SDGs, the importance of the SDGs for economic development after the COVID-19 pandemic, and student interest research in SDG issues. The study is carried out with students in Colombia, Ecuador, Mexico, and Peru. The instrument was developed and validated. The highest score of level of knowledge was reported in Mexico and the lowest score in Colombia. This outcome can be explained by the availability of training programs in the universities about SDGs. The availability of programs created and promoted by the governments can also be a reason; however, students from Mexico are the ones who felt the most that the authorities are not making efforts to promote the SDGs. With research interests, interests in creating sustainable cities and communities, and responsible consumption and production were recognized for the four countries. The outcomes reveal several interesting insights through comparisons among the four countries considered according to descriptive analyses. Some SDGs were found to be more important for some countries than others. Interests were noted in research on some SDGs.