Impact of variants in the VEGF gene on progression of proliferative diabetic retinopathy

Abstract

The AA genotype at -2578C/A polymorphism in the VEGF gene is associated with proliferative diabetic retinopathy. No significant association with -634 C/G polymorphism was confirmed.

Association Between the VEGF Gene Polymorphism and Diabetic Retinopathy Risk: A Meta-Analysis of 4216 Individuals

“…The meta-analysis showed that -634C/G polymorphism C allele and genotypes CC vs CG + GG and CG vs CC + GG had no statistically significant association with DR. The result further verified most former results [13][14][15][16][17][18][19][20][21] . Meta-analysis is a summary analysis method that can combine various similar research results.…”

“…Thus, VEGF5'-untranslated region-634C/G polymorphism is an independent risk factor in DR. However, further studies on the association yielded similar [9][10][11][12] and opposite results [13][14][15][16][17][18][19][20][21] . Even in one country without ethnic diversity, different results were obtained.…”

“…Therefore, the degree of gene VEGF-634C/G polymorphism and its association with DR were systematically analyzed using evidence-based medicine at allele and genotype levels in the present study. A total of 14 case-control studies were retrieved from various populations: three cases each from China [10,11,20] , India [12,13,17] , and Japan [8,9,18] ; two cases from Portland [14,16] ; and one case each from Slovenia [15] , Finland [19] , and Korea [20] . The meta-analysis showed that -634C/G polymorphism C allele and genotypes CC vs CG + GG and CG vs CC + GG had no statistically significant association with DR.…”

Macular oedema as manifestation of diabetic retinopathy

“…Одним из ключевых факторов в прогрессировании ДР признан фактор роста эндотелия сосудов (VEGF) [52].…”

Anti-VEGF agents in the treatment of diabetic macular edema

“…1 206 ) являются продуктами одного гена, образующимися в результате альтернативного сплайсинга мРНК. В гене VEGF выявлены полиморфные позиции -634, +936, -2578; обнаружены взаимосвязи ва-риантов нуклеотидов в этих позициях с риском развития диабетической ретинопатии (ДР) в разных этнических группах [12][13][14][15]. По нашим данным [16,17], для больных СД 2 типа (СД2) свойственны комбинации гомозиготных вариантов VEGF 2578CC, 936CC, генов интерлейкинов и матриксных металлопротеиназ: IL4 590СС, IL6 174GG, IL10 592СC и 1082АА, TNFА 238GG, 308GG и 863СC, MMP-2 1306CC и ММР-9 1562СС.…”