Impact of vitamin D on human embryo implantation—a prospective cohort study in women undergoing fresh embryo transfer

Cai, Sufen; Li, Jian; Zeng, Suimin; Hu, Liang; Peng, Yangqin; Tang, Sha; Zeng, Shufei; Chu, Chang; Gong, Fei; Lin, Ge; Hocher, Berthold

doi:10.1016/j.fertnstert.2020.09.005

Cited by 23 publications

(18 citation statements)

References 52 publications

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“…Participating women received pituitary downregulation protocols exactly as described recently ( 11 , 12 ) (also see study protocol). The reproductive therapy of choice was a transfer of 2 cleavage embryos 3 days after fertilization.…”

Section: Methodsmentioning

confidence: 99%

“…Then the embryo was graded as I to IV according to the following criteria: fragmentation, cell symmetry, nucleation, spatial orientation, compaction, and presence of vacuoles ( 13 ). Embryos scored 7C-II or above were defined as good-quality cleavage embryos in our current study ( 12 ).…”

Section: Methodsmentioning

confidence: 99%

“…The trophectoderm was also graded as A to C based on the number and size of cells forming a cohesive or loose epithelium ( 14 ). Blastocysts scored 4BB or above were defined as good-quality blastocysts in our current study ( 12 ).…”

Section: Methodsmentioning

confidence: 99%

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Blastocyst Transfer: A Risk Factor for Gestational Diabetes Mellitus in Women Undergoing In Vitro Fertilization

Chen

Cai

et al. 2021

The Journal of Clinical Endocrinology &Amp; Metabolism

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Background The risk of developing gestational diabetes mellitus (GDM) is higher in women undergoing assisted reproductive treatment than in women conceiving spontaneously. Objectives To determine whether the GDM risk after day-3 embryo transfer differs from the GDM risk after day-5 blastocyst transfer. Methods Prospective observational study in women becoming pregnant after first fresh embryo or blastocyst transfer. Results A total of 1579 women got pregnant and had live birth; 1300 women got day-3 embryo transfer only, whereas 279 women received at least 1 blastocyst. Of 1579 women, 252 developed GDM. Age, body mass index, baseline estradiol, baseline high-density lipoprotein, and progesterone on the day of human chorionic gonadotropin injection were not different in women receiving day-3 embryos only vs women receiving at least 1 blastocyst. The number and quality of retrieved oocytes were not different in women receiving day-3 embryo transfer from those receiving blastocysts. Our study confirmed already established GDM risk factors such as age and body mass index, baseline estradiol, and high-density lipoprotein, as well as progesterone after ovarian stimulation. We furthermore demonstrate that the GDM incidence in women receiving day-5 blastocyst transfer was significantly higher than those who received day-3 embryo transfer (21.15% vs 14.85%; P = 0.009). Considering confounding factors, we likewise saw that blastocyst transfer was an independent procedure-related GDM risk factor [P = 0.009, Exp (B): 1.56, 95% CI: 1.12-2.18]. Conclusion Blastocyst transfer after in vitro fertilization/intracytoplasmic sperm injection increases the risk of developing GDM.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Blastocyst Transfer: A Risk Factor for Gestational Diabetes Mellitus in Women Undergoing In Vitro Fertilization

Chen

Cai

et al. 2021

The Journal of Clinical Endocrinology &Amp; Metabolism

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“…The level of serum β‐hCG was routinely measured at 14 or 12 days after the transfer of day‐3 embryos or day‐5 blastocysts, respectively, to confirm the outcome. If the serum β‐hCG level was above 200 U/L (biochemical pregnancy) 27 , TVS was scheduled for 2 weeks later to determine the presence of a gestational sac (clinical pregnancy) 31 with or without a fetal pole and fetal heart activity. All TVS scans during the first trimester were performed by experienced sonographers at our imaging department.…”

Section: Methodsmentioning

confidence: 99%

“…One to three good-/fair-quality embryos were transferred into the uterine cavity on day 3 or day 5 of embryo development. Criteria for scoring the embryo/blastocyst have been described previously [27][28][29][30] .…”

Section: Ivf/icsi Proceduresmentioning

confidence: 99%

Pregnancy outcome after in‐vitro fertilization/intracytoplasmic sperm injection in women with congenital uterus didelphys

Cai

Ouyang

Lin

et al. 2022

Ultrasound in Obstet & Gyne

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Objective To investigate the pregnancy and obstetric outcomes of patients with congenital uterus didelphys who achieved clinical pregnancy after in‐vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI). Methods This was a retrospective matched‐cohort study of 83 infertile patients with uterus didelphys who underwent IVF/ICSI and achieved clinical pregnancy from January 2005 to December 2018 at our center. For each patient in the study group, three control patients with normal uterine morphology who underwent IVF/ICSI in 2018 were selected randomly. Patients in the two groups were matched for number of gestational sacs, maternal age, infertility type, cause of infertility, fertilization method, endometrial thickness 1 day before embryo transfer and number of embryos transferred. The classification of congenital uterine anomalies was based on the American Fertility Society system (1988). The pregnancy and obstetric outcomes of the didelphic and control groups were compared separately for singleton and twin pregnancies, and for all pregnancies combined. Results In singleton pregnancies, women with uterus didelphys had increased risk of preterm birth (odds ratio (OR), 4.68; rate difference (RD), 0.14; P < 0.001), Cesarean section (OR, 2.80; RD, 0.17; P = 0.016) and birth weight < 2500 g (OR, 4.06; RD, 0.10; P = 0.017) compared to women with normal uterine morphology. In twin pregnancies, the presence of uterus didelphys was associated with increased risk of preterm delivery (OR, 4.79; RD, 0.37; P = 0.006), perinatal mortality (OR, 3.16; RD, 0.19; P = 0.043) and birth weight < 2500 g (OR, 9.57; RD, 0.35; P = 0.001). Conclusions The presence of uterus didelphys was associated with significantly increased risk of some adverse pregnancy outcomes compared to pregnancies with normal uterine morphology in women who underwent IVF/ICSI. A twin pregnancy in women with uterus didelphys was associated with worse perinatal outcome. © 2021 International Society of Ultrasound in Obstetrics and Gynecology.

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Association Between Vitamin D Level and Clinical Outcomes of Assisted Reproductive Treatment: A Systematic Review and Dose-Response Meta-Analysis

Xu,

An,

Tang

et al. 2024

Reprod. Sci.

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The investigation about association between vitamin D level and clinical outcomes of assisted reproductive treatment showed various outcomes. This study aimed to review the correlation between vitamin D and outcomes of assisted reproductive treatment. The search was registered on the PROSPERO database (CRD42023458040). PubMed, Embase, Medline, ClinicalTrials.gov, and Cochrane databases were searched up to July 2023. Twenty-three observational studies were selected for meta-analysis. Comparing groups with deficient and ‘insufficient + sufficient’ vitamin D level, meta-analysis showed positive correlation between clinical pregnancy rate and vitamin D (OR 0.81, 95%CI: 0.70, 0.95, P = 0.0001). Comparing groups with ‘deficient + insufficient’ and sufficient vitamin D level, meta-analysis showed positive correlation between vitamin D and clinical pregnancy rate (OR 0.71, 95%CI: 0.55, 0.91, P = 0.006), vitamin D and live birth rate (OR 0.69, 95%CI: 0.54, 0.89, P = 0.003). Subgroup analysis did not show the source of high heterogeneity. No correlation was found in biochemical pregnancy rate, ongoing pregnancy rate, miscarriage rate and implantation rate. In dose-response meta-analysis, a nonlinear association was found between vitamin D levels and outcomes when levels are below approximately 24 ng/L. The study shows that vitamin D level is associated with clinical pregnancy rate and live birth rate. Low vitamin D level does not influence biochemical pregnancy rate, ongoing pregnancy rate, miscarriage rate and implantation rate. Furthermore, 24 ng/L may be a possible threshold of vitamin D concentration in assisted reproduction therapy.

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Impact of vitamin D on human embryo implantation—a prospective cohort study in women undergoing fresh embryo transfer

Cited by 23 publications

References 52 publications

Blastocyst Transfer: A Risk Factor for Gestational Diabetes Mellitus in Women Undergoing In Vitro Fertilization

Blastocyst Transfer: A Risk Factor for Gestational Diabetes Mellitus in Women Undergoing In Vitro Fertilization

Pregnancy outcome after in‐vitro fertilization/intracytoplasmic sperm injection in women with congenital uterus didelphys

Association Between Vitamin D Level and Clinical Outcomes of Assisted Reproductive Treatment: A Systematic Review and Dose-Response Meta-Analysis

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