Impact of vitamin D supplementation on cardio-metabolic status and androgen profile in women with polycystic ovary syndrome: placebo-controlled clinical trial

Rashad, Nearmeen M.; El-Fatah, Azza H. Abd; Lashin, Mohamed El-Bakry; Abomandour, Hala Gouda; Allam, Reem M.

doi:10.1186/s43043-019-0005-y

Cited by 7 publications

(16 citation statements)

References 42 publications

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“…In agreement with our results, Rashad et al showed that VD 3 level was negatively correlated with free testosterone. 17 In contrast to our results, Arslan et al demonstrated that AMH levels were not correlated with 25(OH)D levels in PCO group. 18 This may be contributed to different ethnic group or geographical factors or different lifestyle.…”

Section: Discussioncontrasting

confidence: 99%

Relationship between vitamin D3 deficiency and polycystic ovarian syndrome

Elsadany

Elshwaikh

Borg

et al. 2022

Int J Reprod Contracept Obstet Gynecol

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Background: Vitamin D3 (VD3), a seco-steroid that is synthesized in skin and sequentially metabolized in liver and kidneys in humans, has been well-known for its function in maintaining calcium and phosphorus homeostasis and promoting bone mineralization. Polycystic ovary syndrome (PCOS) is a common cause of ovarian dysfunction in women with anovulation. Aim of this study is to show and evaluate VD3 level in women who are suffering from polycystic ovarian syndrome.Methods: This study was conducted on 200 women; group A: (study group) 100 infertile women who were suffering from PCOS and group B: (control group) 100 patients were selected with other cause of infertility than PCOS. US examination, hormonal profile (FSH, LH, AMH, TSH and prolactin level) and laboratory assay of serum VD3 level (postmenstrual) were done for every patient to evaluate relationship between VD3 deficiency and PCOS patients.Results: There was a significant relationship between group A compared to group B as regards irregular menstrual cycle, clinical hyperandrogenism, LH/FSH ratio and AMH. There was no significant difference between both groups as regards TSH, prolactin and VD3 level. VD was deficient in both groups as it was lower than normal level. There was a negative significant correlation between VD3 level and both hyperandrogenism and AMH.Conclusions: There was VD3 deficiency in PCO patients and infertile cases due to another factor, and negative significant correlation between VD3 level and clinical hyperandrogenism, LH/FSH ratio, menstrual cycle and AMH.

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Section: Discussioncontrasting

confidence: 99%

Relationship between vitamin D3 deficiency and polycystic ovarian syndrome

Elsadany

Elshwaikh

Borg

et al. 2022

Int J Reprod Contracept Obstet Gynecol

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“…Rashad et al found that the clinical manifestations, metabolic indices, and androgenic aspects of PCOS have improved. Body composition measures, BMI, and waist-hip ratio all decreased significantly in the intervention group [17]. Furthermore, after getting vitamin D3 medication, cardio-metabolic risks were reduced, and a novel finding in this clinical trial was a reduction in pro-inflammatory biomarkers.…”

Section: Resultsmentioning

confidence: 63%

Impact of Vitamin D Deficiency on the Pathogenesis of Polycystic Ovary Syndrome

Raheem¹,

Marouf

2022

Al-Rafidain J Med Sci

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There are many metabolic and hormonal factors related to polycystic ovary syndrome (PCOS) that can be affected by vitamin D3 supplementation. To find clinical trials, in vivo studies, and in vitro studies that met the review's inclusion and exclusion criteria, we searched many databases. PCOS women's ovulation and metabolic parameters were examined in relation to the effects of vitamin D3 treatment on PCOS risk variables such as seasonal changes in body mass index, and obesity. The current review included twenty-five articles. Vitamin D3(25-hydroxy vitamin D) levels were significantly lower in the PCOS group than in the control group, and lipid profile and androgen hormone levels were significantly higher in the PCOS group, resulting in increased cardiovascular events and exaggerated hirsutism. According to the majority of research, vitamin D3 plays a beneficial role in decreasing the pathophysiology of PCOS, notably in restoring ovulation, which ultimately improves fertility. Although other studies found no effect on lipid profile, there was a minor effect on reducing cardiovascular risks. The response of patients to vitamin D3 was influenced by the dose administered and the study's methodology. In conclusion, vitamin D3 had a good effect on the pathophysiology of PCOS in the majority of investigations.

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“…This is due to the limited ability of immunoassays to accurately quantify low levels of testosterone, cross-reactivity with steroid metabolites, precursors and conjugates, and regular changes in proprietary assay reagents [26]. Additionally, some of these studies have also failed to adjust for important confounders such as insulin resistance and/or BMI [7,8,27], which are often elevated in an individual's PCOS, and directly affect androgens [28,29]. However, we saw no correlations between vitamin D components and androgens even before adjustment for these confounders.…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Vitamin D Metabolites and Androgens in Women with Polycystic Ovary Syndrome

et al. 2020

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Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age, with hyperandrogenism present in up to 90% of affected women. Some evidence suggests a link between vitamin D deficiency and PCOS features via insulin resistance and inflammation. Our aim was to explore the relationship between biochemical markers of vitamin D status and androgens in women with PCOS. This cross-sectional study used bio-banked samples from 46 pre-menopausal women with PCOS (mean ± SD: age 30 ± 6 years; BMI 29 ± 6 kg/m2). We measured 25-hydroxyvitamin D (25[OH]D), vitamin D-binding protein (DBP), total testosterone, sex hormone-binding globulin (SHBG), and calculated the free androgen index (FAI) and bioavailable and free 25(OH)D. Fasting glucose and insulin were used to calculate the homeostatic model assessment of insulin resistance (HOMA-IR) and body fat percentage was determined via dual energy x-ray absorptiometry. High-sensitivity C-reactive protein (hs-CRP) was measured as a marker of inflammation. DBP was positively associated with total 25(OH)D and expectedly, negatively associated with free 25(OH)D. There were no associations between vitamin D metabolites and total testosterone, SHBG or FAI, even after adjusting for age, body fat percentage, HOMA-IR and hs-CRP. We found no associations between vitamin D metabolites and androgens in women with PCOS. Studies that have identified a vitamin D–androgen link have largely relied on methodology with numerous pitfalls; future studies should exclusively use gold-standard measures to confirm these findings in this population.

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Impact of vitamin D supplementation on cardio-metabolic status and androgen profile in women with polycystic ovary syndrome: placebo-controlled clinical trial

Cited by 7 publications

References 42 publications

Relationship between vitamin D3 deficiency and polycystic ovarian syndrome

Relationship between vitamin D3 deficiency and polycystic ovarian syndrome

Impact of Vitamin D Deficiency on the Pathogenesis of Polycystic Ovary Syndrome

The Relationship between Vitamin D Metabolites and Androgens in Women with Polycystic Ovary Syndrome

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