Impact of Vitamin D3 Supplementation on Recurrent Aphthous Ulcer

Hussein, Fatma Fathi; Sadek, H. S.; Elmarssafy, Lama Hussein

doi:10.36468/pharmaceutical-sciences.spl.440

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results of the present updated meta-analysis confirm our original meta-analysis ( 31 ), and substantiate many previous systematic reviews and meta-analyses that found significant associations between vitamin D deficiency and several autoimmune diseases and dermatological conditions such as lupus erythematosus, vitiligo, autoimmune bullous dermatoses, rheumatoid arthritis, and primary Sjögren's syndrome ( 22 – 26 ). Interestingly, our results are in accord with a recent clinical trial which investigated the efficacy of vitamin D supplementations in RAS patients with vitamin D deficiency, and reported a significant reduction in the frequency of RAS episodes, number of ulcers, and duration of healing time after one year ( 45 ). The exact mechanism behind the effects of vitamin D on RAS is still unclear yet, but may be explained by its immunomodulatory effects.…”

Section: Discussionsupporting

confidence: 92%

Vitamin D deficiency and risk of recurrent aphthous stomatitis: updated meta-analysis with trial sequential analysis

et al. 2023

View full text Add to dashboard Cite

BackgroundGrowing evidence suggests a significant association between vitamin D deficiency and RAS. Hence, the present meta-analysis and trial sequential analysis sought to investigate the potential association between low serum vitamin D levels and RAS.MethodsPubMed, Scopus, Embase, and Web of Science were comprehensively searched on December 1st, 2022 to retrieve all relevant studies. The grey literature was also searched via ProQuest. All case-control studies on the association between vitamin D and RAS were considered. The quality appraisal of the included studies was done using Newcastle-Ottawa scale. RevMan 5.0 and trial sequential analysis (TSA) programs were used for analyses.ResultsA total of 14 case-control studies with 1468 subjects (721 RAS patients and 747 controls) were included. The pooled data revealed a significant association between low serum levels of vitamin D and the risk of RAS (mean difference = – 8.73, 95% CI: – 12.02 to – 5.44, I2 = 94%, P < 0.00001). Additionally, TSA findings indicated that the current studies surpassed the required information size, confirming that the differences were reliable.ConclusionThe available evidence suggests that Vitamin D deficiency may have a role in the pathogenesis of RAS. Therefore, evaluation of vitamin D should be considered in RAS patients. Additionally, the results support the possibility of using vitamin D supplements in the management of RAS patients with inadequate serum levels of vitamin D. Future interventional studies are required to evaluate the benefits of vitamin D replacement in prevention and treatment of RAS.

show abstract