Impact of wastage on single and multi-dose vaccine vials: Implications for introducing pneumococcal vaccines in developing countries

Parmar, Divya; Baruwa, Elaine; Zuber, Patrick; Kone, Souleymane

doi:10.4161/hv.6.3.10397

Cited by 64 publications

(54 citation statements)

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“…Although 98% of heads of households surveyed in the community assessment reported that they would use a free typhoid vaccine to protect their family from typhoid fever, we assumed a more conservative vaccination coverage rate that varied between 60% and 75% [Personal Communication, K. Date, C.D.C., Atlanta]. The vaccine wastage rate was estimated at 10%, in accordance with values obtained for previous vaccination campaigns [26,27]. Consistent with the public sector health care delivery perspective, vaccinees' lost productivity and transportation costs associated with obtaining the vaccines were not included in the estimated campaign costs.…”

Section: Vaccination Campaign Costmentioning

confidence: 73%

Economic evaluation of typhoid vaccination in a prolonged typhoid outbreak setting: The case of Kasese district in Uganda

Carias

Wefula²,

Date

et al. 2015

Vaccine

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a b s t r a c tBackground: Vaccination has been increasingly promoted to help control epidemic and endemic typhoid fever in high-incidence areas. Despite growing recognition that typhoid incidence in some areas of subSaharan Africa is similar to high-incidence areas of Asia, no large-scale typhoid vaccination campaigns have been conducted there. We performed an economic evaluation of a hypothetical one-time, fixed-post typhoid vaccination campaign in Kasese, a rural district in Uganda where a large, multi-year outbreak of typhoid fever has been reported. Methods: We used medical cost and epidemiological data retrieved on-site and campaign costs from previous fixed-post vaccination campaigns in Kasese to account for costs from a public sector health care delivery perspective. We calculated program costs and averted disability-adjusted life years (DALYs) and medical costs as a result of vaccination, to calculate the cost of the intervention per DALY and case averted. Results: Over the 3 years of projected vaccine efficacy, a one-time vaccination campaign was estimated to avert 1768 (90%CI: 684-4431) typhoid fever cases per year and a total of 3868 (90%CI: 1353-9807) DALYs over the duration of the immunity conferred by the vaccine. The cost of the intervention per DALY averted was US$ 484 (90%CI: 18-1292) and per case averted US$ 341 (90%CI: 13-883). Conclusion: We estimated the vaccination campaign in this setting to be highly cost-effective, according to WHO's cost-effective guidelines. Results may be applicable to other African settings with similar high disease incidence estimates.

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Section: Vaccination Campaign Costmentioning

confidence: 73%

Economic evaluation of typhoid vaccination in a prolonged typhoid outbreak setting: The case of Kasese district in Uganda

Carias

Wefula²,

Date

et al. 2015

Vaccine

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“…Though there are very few countries reporting vaccine wastage to World Health Organization, WHO (19 of the 72 Global Alliance for Vaccine Initiative, GAVI eligible countries), developing countries have been found to incur cost of vaccine wastage in excess of $4 million and $6 million for pentavalent and pneumococcus vaccines respectively. It is noteworthy that Nigeria is among the 74% of GAVI eligible countries that do not report vaccine wastage 4 . Periodic assessment of vaccine handling and storage practices is instrumental in correcting wrong vaccine management practices and improving level of knowledge on vaccine management 5,6 .…”

Section: Introductionmentioning

confidence: 99%

Factors affecting vaccine handling and storage practices among immunization service providers in Ibadan, Oyo State, Nigeria

Dairo¹,

Osizimete²

2016

Afr H. Sci.

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Background: Improper handling has been identified as one of the major reasons for the decline in vaccine potency at the time of administration. Loss of potency becomes evident when immunised individuals contract the diseases the vaccines were meant to prevent. Objective: Assessing the factors associated with vaccine handling and storage practices. Methods: This was a cross-sectional study. Three-stage sampling was used to recruit 380 vaccine handlers from 273 health facilities from 11 Local Government areas in Ibadan. Data was analysed using SPSS version 16 Results: Seventy-three percent were aware of vaccine handling and storage guidelines with 68.4% having ever read such guidelines. Only 15.3% read a guideline less than 1 month prior to the study. About 65.0% had received training on vaccine management. Incorrect handling practices reported included storing injections with vaccines (13.7%) and maintaining vaccine temperature using ice blocks (7.6%). About 43.0% had good knowledge of vaccine management, while 66.1% had good vaccine management practices. Respondents who had good knowledge of vaccine handling and storage [OR=10.0, 95%CI (5.28 -18.94), p < 0.001] and had received formal training on vaccine management [OR=5.3, 95%CI (2.50 -11.14), p< 0.001] were more likely to have good vaccine handling and storage practices. Conclusion: Regular training is recommended to enhance vaccine handling and storage practices.

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“…The new presentation, cPAD, might help to increase vaccine coverage, especially in hard-to-reach situations, 15,42 because it simplifies transport and logistics by being lightweight, 43 with a small volume, 43,44 safe disposal, 29,42 easy to use presentation simplifying vaccine administration, 15,20,21,42 and reducing handling errors. 15,19,45,46 It also offers several other benefits including reduced missed vaccination opportunities due to mismatch between vaccine doses and consumables (needles and syringes) as all required components are present at the same place and time, 29,42,43 increased vaccine coverage by reducing vaccination time (six times quicker administration versus a single-dose lyophilized vial), 21 and less vaccine wastage 45,[47][48][49] as the singledose presentation ensures opened multi-dose vials are not discarded. The contamination risk is also expected to be minimized as vaccine sterility is maintained right up to the point of administration, 42,45 and the auto-disable feature prevents needle and syringe reuse.…”

Section: Discussionmentioning

confidence: 98%

Comparison of the immunogenicity and safety of pentavalent vaccine Quinvaxem in a compact prefilled auto-disabled (cPAD) injection system versus single-dose vials in healthy infants: a phase 3, open-label, randomized, parallel-group, non-inferiority study

Capeding

Alberto

Versteilen

et al. 2016

International Journal of Infectious Diseases

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Impact of wastage on single and multi-dose vaccine vials: Implications for introducing pneumococcal vaccines in developing countries

Cited by 64 publications

References 0 publications

Economic evaluation of typhoid vaccination in a prolonged typhoid outbreak setting: The case of Kasese district in Uganda

Economic evaluation of typhoid vaccination in a prolonged typhoid outbreak setting: The case of Kasese district in Uganda

Factors affecting vaccine handling and storage practices among immunization service providers in Ibadan, Oyo State, Nigeria

Comparison of the immunogenicity and safety of pentavalent vaccine Quinvaxem in a compact prefilled auto-disabled (cPAD) injection system versus single-dose vials in healthy infants: a phase 3, open-label, randomized, parallel-group, non-inferiority study

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