Impact of Work Task-Related Acute Occupational Smoke Exposures on Select Proinflammatory Immune Parameters in Wildland Firefighters

Adetona, Anna M.; Adetona, Olorunfemi; Gogal, Robert M.; Díaz-Sánchez, David; Rathbun, Stephen L.; Naeher, Luke P.

doi:10.1097/jom.0000000000001053

Cited by 43 publications

(52 citation statements)

References 20 publications

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“…The subjects did not use respiratory protection during the study. A detailed description of the sample collection methods and gravimetric analyses were reported previously (Adetona AM 2016) In brief, all exposure monitoring instruments were calibrated prior to use, and gravimetric analyses followed the United States Environmental Protection Agency (U.S. EPA) specifications (U.S. Environmental Protection Agency.…”

Section: Methodsmentioning

confidence: 99%

Urinary mutagenicity and other biomarkers of occupational smoke exposure of wildland firefighters and oxidative stress

Adetona

Martin

Warren

et al. 2019

Inhalation Toxicology

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Background: Wildland firefighters conducting prescribed burns are exposed to a complex mixture of pollutants, requiring an integrated measure of exposure. Objective: We used urinary mutagenicity to assess if systemic exposure to mutagens are higher in firefighters after working at prescribed burns versus after non-burn work days. Other biomarkers of exposure and oxidative stress markers were also measured. Methods: Using a repeated measures study design, we collected urine before, immediately after, and the morning after a work shift on prescribed burn and non-burn work days from 12 healthy subjects. Urines were analyzed for malondialdehyde (MDA), 8-isoprostane, 1-hydroxypyrene (OH-Pyrene), and mutagenicity in Salmonella YG1041 +S9. Particulate matter (PM2.5) and carbon monoxide (CO) measurements were collected by personal monitoring. Light-absorbing carbon (LAC) of PM2.5 was measured as a surrogate for black carbon exposure. Linear mixed-effect models were used to assess cross-work shift (pre- to post-work shift) changes in urinary biomarkers. Results: No significant differences occurred in creatinine-adjusted urinary mutagenicity across the work shift between burn days (48 samples) and non-burn day (21 samples). Firefighters lighting fires had a non-significant, 1.6-fold increase in urinary mutagenicity for burn- versus non-burn day exposures. Positive associations were found between cross-work shift (pre- to post-) changes in creatinine-adjusted urinary mutagenicity and MDA (p = 0.0010), OH-Pyrene (p = 0.0001), and mass absorption efficiency, which is the LAC/PM2.5 ratio (p = 0.2245), respectively. No significant effect of day type or work task on cross-work shift (pre- to post-) changes in MDA or 8-isoprostane was observed. Conclusion: Urinary mutagenicity may serve as a suitable measure of occupational smoke exposures among wildland firefighters, especially among those lighting fires for prescribed burns.

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Section: Methodsmentioning

confidence: 99%

Urinary mutagenicity and other biomarkers of occupational smoke exposure of wildland firefighters and oxidative stress

Adetona

Martin

Warren

et al. 2019

Inhalation Toxicology

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“…[42] For occupational exposure to combustion particles, both positive and negative studies were identified. [22,50,[80][81][82][83] Taken together, occupational biomonitoring studies report increased blood levels of acute phase response proteins among workers following occupational exposure to particles especially in controlled studies, where the participants serve as their own control. In other studies, including cross-sectional studies, positive correlations between exposure to particles and acute phase response proteins CRP and SAA were found.…”

Section: Biomonitoring Studies Of Occupational Exposure To Particles mentioning

confidence: 99%

Acute Phase Response as a Biological Mechanism‐of‐Action of (Nano)particle‐Induced Cardiovascular Disease

Hadrup

Zhernovkov

Jacobsen

et al. 2020

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Inhaled nanoparticles constitute a potential health hazard due to their size-dependent lung deposition and large surface to mass ratio. Exposure to high levels contributes to the risk of developing respiratory and cardiovascular diseases, as well as of lung cancer. Particle-induced acute phase response may be an important mechanism of action of particleinduced cardiovascular disease. Here, the authors review new important scientific evidence showing causal relationships between inhalation of particle and nanomaterials, induction of acute phase response, and risk of cardiovascular disease. Particle-induced acute phase response provides a means for risk assessment of particle-induced cardiovascular disease and underscores cardiovascular disease as an occupational disease.

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“…Detail of the recruitment procedure has been previously reported. 14 Briefly, twelve healthy wildland firefighters (9 males and 3 females with an average age of 33 years) were recruited from US Forest Service-Savannah River Site, SC during January to July 2015. The subjects were briefed face-to-face on the purpose, design, and sample collection procedures of the study.…”

Section: Methodsmentioning

confidence: 99%

Measuring acute pulmonary responses to occupational wildland fire smoke exposure using exhaled breath condensate

Adetona

Song

et al. 2019

Archives of Environmental & Occupational Health

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Wildland firefighters are directly exposed to elevated levels of wildland fire smoke (WF smoke). Although studies demonstrate WF smoke exposure is associated with lung function changes, few studies that use invasive sample collection methods have been conducted to investigate underlying biochemical changes. These methods are also either unrepresentative of the deeper airways or capable of inducing inflammation. In the present study, levels of biomarkers of oxidative stress (8isoprostane) and pro-inflammatory response (interleukin-6 [IL-6], interleukin-8 [IL-8], C-reactive protein [CRP], and soluble intercellular adhesion molecule-1 [sICAM-1]) were determined in exhaled breath condensate (EBC) samples that were collected from firefighters before, after, and next morning of prescribed burn and regular work shifts. Results show only a marginal cross-shift increase in 8-isoprostane on burn days (0.05 < p-value < 0.1), suggesting WF smoke exposure causes mild pulmonary responses.

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Impact of Work Task-Related Acute Occupational Smoke Exposures on Select Proinflammatory Immune Parameters in Wildland Firefighters

Abstract: Results from this study suggest that intermittent occupational diesel exposures contribute to cross-work-shift changes in host systemic innate inflammation as indicated by elevated interleukin-8 levels and peripheral blood segmented-neutrophils.

Cited by 43 publications

References 20 publications

Urinary mutagenicity and other biomarkers of occupational smoke exposure of wildland firefighters and oxidative stress

Urinary mutagenicity and other biomarkers of occupational smoke exposure of wildland firefighters and oxidative stress

Acute Phase Response as a Biological Mechanism‐of‐Action of (Nano)particle‐Induced Cardiovascular Disease

Measuring acute pulmonary responses to occupational wildland fire smoke exposure using exhaled breath condensate

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