Impact of Young Age at Diagnosis on Survival in Patients with Surgically Treated Renal Cell Carcinoma: a Multicenter Study

Abstract

The prognostic significance of age in renal cell carcinoma (RCC) is a subject of debate. The aim of the present multi-institutional study was to evaluate the impact of age on clinicopathological features and survival in a large cohort of patients with RCC. A total of 5,178 patients who underwent surgery for RCC at eight institutions in Korea between 1999 and 2011 were categorized into three groups according to age at diagnosis as follows: young age (< 40 years, n = 541), middle-age (≥ 40 and < 60 years, n = 2,551), and old age (≥ 60 years, n = 2,096) groups. Clinicopathological variables and survival rates were compared between the three groups. Young patients had lower stage tumors with a low Fuhrman grade, a lower rate of lymphovascular invasion than patients in the other age groups. Regarding histologic type, the young age group had a lower percentage of clear cell histology and a greater incidence of Xp11.2 translocation RCC. Kaplan-Meier estimates showed that cancer-specific survival was significantly better in the young age group than in the other groups (log rank test, P = 0.008). However, age at diagnosis was not an independent predictor of survival in multivariate analysis. In conclusion, young age at diagnosis was associated with favorable pathologic features, although it was not an independent prognostic factor for survival in patients with surgically-treated RCC. Age itself should not be regarded as a crucial determinant for the treatment of RCC.

Age‐dependent prognostic value of body mass index for non‐metastatic clear cell renal cell carcinoma: A large multicenter retrospective analysis

“…Regarding clinical and pathological characteristics according to age, recent studies have indicated that older patients are more likely to have a poorer general condition and more aggressive pathological features than young patients . We also observed similar trends, with older patients having higher values for ECOG PS, T stage, and Fuhrman grade.…”

53 Years Old is A Reasonable Cut-Off Value To Define Young And Old Patients In Clear Cell Renal Cell Carcinoma:A Study Based On TCGA And SEER Database

“…Some studies reported that the 40 years old was suitable to act as the dividing line between young and old CCRCC patients. Xavier Taccoen But the result of the Kaplan-Meier analysis showed that the CCS rate was significantly better in the young age group than the other groups (middle age: ≥ 4 and < 60 years ; old age: ≥ 60 years) [10].…”

Age is a powerful predictor of survival in pT2N0M0 clear cell renal cell cancer patients: A SEER-based study

“…Most previous studies reported the role of age as a prognostic factor in RCC patients with all subtypes and all stages, telling conflicting conclusions [7,[11][12][13][14][15][16][17][18][19][20]. Of these studies, some have claimed that the prognosis of RCC in younger patients did not differ from that in older patients [13][14][15]. The most recent multicenter study including 5,178 patients who underwent surgery for RCC showed no significant difference in CSS among three age groups (< 40 years, ≥ 40 and < 60 years, ≥60 years) [15].…”

“…Of these studies, some have claimed that the prognosis of RCC in younger patients did not differ from that in older patients [13][14][15]. The most recent multicenter study including 5,178 patients who underwent surgery for RCC showed no significant difference in CSS among three age groups (< 40 years, ≥ 40 and < 60 years, ≥60 years) [15]. However, more studies reported better CSS rates in young RCC patients than in older ones [16][17][18][19][20].…”