Impact of Zika virus on the human type I interferon osteoimmune response

Drouin, Arnaud; Wallbillich, Nicholas; Theberge, Marc; Liu, Sharon; Katz, Joshua P.; Bellovoda, Kamela; Cheon, Scarlett Se Yun; Gootkind, Frederick; Bierman, Emily; Zavras, Jason; Berberich, Matthew J.; Kalocsay, Marian; Guastaldi, Fernando Pozzi Semeghini; Salvadori, Nicolas; Troulis, Maria J.; Fusco, Dahlene N.

doi:10.1016/j.cyto.2020.155342

Cited by 5 publications

(3 citation statements)

References 85 publications

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“…In general, the osteoclasts-T-lymphocytes-bone destruction pathway was once the central topic of bone immunology and has been extensively explained (9,15). Besides, there is increasing evidence that the concept of osteoimmunity extends to osteoblasts, but it has not been well elucidated in comparison with osteoclasts (16,17). Therefore, we do not discuss the above two branches of osteoimmunity here.…”

Section: Osteoimmunitymentioning

confidence: 99%

The Macrophage-Osteoclast Axis in Osteoimmunity and Osteo-Related Diseases

et al. 2021

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Osteoimmunity is involved in regulating the balance of bone remodeling and resorption, and is essential for maintaining normal bone morphology. The interaction between immune cells and osteoclasts in the bone marrow or joint cavity is the basis of osteoimmunity, in which the macrophage-osteoclast axis plays a vital role. Monocytes or tissue-specific macrophages (macrophages resident in tissues) are an important origin of osteoclasts in inflammatory and immune environment. Although there are many reports on macrophages and osteoclasts, there is still a lack of systematic reviews on the macrophage-osteoclast axis in osteoimmunity. Elucidating the role of the macrophage-osteoclast axis in osteoimmunity is of great significance for the research or treatment of bone damage caused by inflammation and immune diseases. In this article, we introduced in detail the concept of osteoimmunity and the mechanism and regulators of the differentiation of macrophages into osteoclasts. Furthermore, we described the role of the macrophage-osteoclast axis in typical bone damage caused by inflammation and immune diseases. These provide a clear knowledge framework for studying macrophages and osteoclasts in inflammatory and immune environments. And targeting the macrophage-osteoclast axis may be an effective strategy to treat bone damage caused by inflammation and immune diseases.

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Section: Osteoimmunitymentioning

confidence: 99%

The Macrophage-Osteoclast Axis in Osteoimmunity and Osteo-Related Diseases

et al. 2021

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“…Knockdown of HELZ2 in KO-IFNAR1 could further increase the DTMUV RNA level at later stages of infection. However, HELZ2 cannot restrict Zika virus (ZIKV) propagation in osteoblast-like Saos-2 cells [ 25 ] and AIV infection could not induce the expression of HELZ2 in DF-1cells [ 26 ]. IFI6 inhibits the replication of multiple flaviviruses, including Yellow Fever Virus (YFV), West Nile Virus (WNV), DENV and ZIKV [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Construction and Transcriptomic Study of Chicken IFNAR1-Knockout Cell Line Reveals the Essential Roles of Cell Growth- and Apoptosis-Related Pathways in Duck Tembusu Virus Infection

Xiang

Yang

Xiong

et al. 2022

Viruses

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For industrial vaccine production, overwhelming the existing antiviral innate immune response dominated by type I interferons (IFN-I) in cells would be a key factor improving the effectiveness and production cost of vaccines. In this study, we report the construction of an IFN-I receptor 1 (IFNAR1)-knockout DF-1 cell line (KO-IFNAR1), which supports much more efficient replication of the duck Tembusu virus (DTMUV), Newcastle disease virus (NDV) and gammacoronavirus infectious bronchitis virus (IBV). Transcriptomic analysis of DTMUV-infected KO-IFNAR1 cells demonstrated that DTMUV mainly activated genes and signaling pathways related to cell growth and apoptosis. Among them, JUN, MYC and NFKBIA were significantly up-regulated. Furthermore, knockdown of zinc-fingered helicase 2 (HELZ2) and interferon-α-inducible protein 6 (IFI6), the two genes up-regulated in both wild type and KO-IFNAR1 cells, significantly increased the replication of DTMUV RNA. This study paves the way for further studying the mechanism underlying the DTMUV-mediated IFN-I-independent regulation of virus replication, and meanwhile provides a potential cell resource for efficient production of cell-based avian virus vaccines.

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“…Analysis in chicken cells demonstrated that HELZ2 is controlled by the MDA5 receptor that senses double stranded RNA (14). However, not all RNA viruses induce HELZ2 expression in every cell type, since infection of Saos-2 human osteosarcoma cells by Zika virus has no effect (15). Consistent with regulation of HELZ2 by interferon and pattern recognition receptors, a study reported that it mediates the inhibition of Dengue virus infection in human hepatic cells induced by IFN-α (16).…”

Section: Introductionmentioning

confidence: 99%

HELZ2: a new, interferon-regulated, human 3’-5’ exoribonuclease of the RNB family is expressed from a non-canonical initiation codon

Huntzinger

Sinteff

Morlet

et al. 2023

Preprint

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Proteins containing a RNB domain, originally identified in E. coli RNase II, are widely present throughout the tree of life. Many RNB proteins are endowed with 3'-5' exoribonucleolytic activity but some have lost catalytic function during evolution. Database searches identified a new RNB domain containing protein in human: HELZ2. Analysis of genomic and expression data with evolutionary information suggested that the human HELZ2 protein is produced from an unforeseen non-canonical initiation codon in Hominidae. This unusual property was confirmed experimentally, extending the human protein by 247 residues. Human HELZ2 was further shown to be an active ribonuclease despite the substitution of a key residue in its catalytic center. HELZ2 harbors also two RNA helicase domains and several zinc-fingers and its expression is induced by interferon treatment. We demonstrate that HELZ2 is able to degrade structured RNAs through the coordinated ATP-dependent displacement of duplex RNA mediated by its RNA helicase domains and its 3'-5' ribonucleolytic action. The expression characteristics and biochemical properties of HELZ2 support a role for this factor in response to viruses and/or mobile elements.

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Impact of Zika virus on the human type I interferon osteoimmune response

Cited by 5 publications

References 85 publications

The Macrophage-Osteoclast Axis in Osteoimmunity and Osteo-Related Diseases

The Macrophage-Osteoclast Axis in Osteoimmunity and Osteo-Related Diseases

Construction and Transcriptomic Study of Chicken IFNAR1-Knockout Cell Line Reveals the Essential Roles of Cell Growth- and Apoptosis-Related Pathways in Duck Tembusu Virus Infection

HELZ2: a new, interferon-regulated, human 3’-5’ exoribonuclease of the RNB family is expressed from a non-canonical initiation codon

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