Impacto da proteína-C reativa no risco cardiovascular de adolescentes

Silva, Isis Tande da; Sanches, Letícia Bertoldi; Mello, Ana Paula de Queiroz; Damasceno, Nágila Raquel Teixeira

doi:10.1590/s0066-782x2010005000027

Cited by 14 publications

(6 citation statements)

References 26 publications

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“…Some studies have Revista de Nutrição http://dx.doi.org/10.1590/1415-52732014000300002 indicated that excess weight is the risk factor most strongly associated with dyslipidemia and this is due to multiple metabolic causes: insulin resistance, hyperinsulinemia, hyperglycemia, increased protein transferring cholesterol esters secreted by adipocytes, among others 28 .…”

Section: Discussionmentioning

confidence: 99%

C-reactive protein and cardiometabolic risk factors in overweight or obese children and adolescents

Cardoso

Carvalho

et al. 2014

Rev. Nutr.

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OBJECTIVE: To investigate the relationship between ultrasensitive C-reactive protein and cardiometabolic risk factors in overweight or obese childrenand adolescents. METHODS: Cross-sectional study conducted at the Center for Childhood Obesity in the period from April 2009 to April 2010, involving 185 overweight children and adolescents aged 2 to 18 years. Measures of ultrasensitive C-reactive protein according to age, nutritional status, gender, race, cardiometabolic risk factors (waist circumference, lipid profile, impaired fasting glucose, high blood pressure and presence of insulin resistance) were compared through the Chi-square test and analysis of variance. All analyses were performed using the Statistical Package for the Social Sciences software version 17.0, adopting a significance level of 5%. RESULTS: Altered high-density lipoprotein was the most frequent cardiometabolic risk factor, and there was a significant association between altered ultrasensitive C-reactive protein values and severe obesity (p=0.005), high waist circumference (p<0.001), hypertriglyceridemia (p=0.037) and insulin resistance (p=0.002), as well as significantly higher body mass index (p=0.000), waist circumference (p=0.001), insulin (p=0.005) and index of glucose homeostasis values(p=0.005). CONCLUSION: High prevalence of altered ultrasensitive C-reactive protein and significant association with severe obesity, waist circumference, hypertriglyceridemia and insulin resistance were observed.

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Section: Discussionmentioning

confidence: 99%

C-reactive protein and cardiometabolic risk factors in overweight or obese children and adolescents

Cardoso

Carvalho

et al. 2014

Rev. Nutr.

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“…There is also evidence in the literature of a positive correlation between elevated CRP-us levels and hyperglycemia, hypertension, smoking and presence of MS or abnormal plasma lipid levels. 6,15,[23][24][25] Hyperglycemia is related to inflammation because of formation of advanced glycation end products (AGEs), which can lead to synthesis of IL-6, to activation of macrophages and to oxidative stress, which culminates in production of CRP, contributing to inflammation. Advanced glycation end products are derived from non-enzymatic reaction of glucose (in addition to oxidation of glucose) with proteins, lipids and nucleic acids, leading to oxidative stress and subsequent development of inflammatory and thrombotic processes.…”

Section: Inflammation: Can It Be Measured?mentioning

confidence: 99%

Síndrome metabólica, aterosclerose e inflamação: tríade indissociável?

et al. 2015

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Populations all over the world are increasingly inactive and are consuming increasing quantities of fats and sugars, which is generally linked to industrially processed foods. The consequences have rapidly manifest as an increase in overweight/obesity and in physiological and metabolic changes, such as the Metabolic Syndrome, which is a series of changes in glycemia, lipids and blood pressure. There is evidence of a close relationship between these changes and inflammatory processes, which can also be linked to oxidative stress. These conditions lead to the pathogenesis of vascular abnormalities or intensify metabolic processes that accompany the metabolic syndrome. The objective of this review is to compare the large number of bibliographic references that show correlations between components of the Metabolic Syndrome and increases in the mediators of inflammation. The publications reviewed were located using the Pubmed, Scopus, Lilacs and Scielo databases and the majority of the articles selected were published within the last 5 years.Keywords: metabolic syndrome ; arteriosclerosis; inflammation. ResumoObserva-se, nas populações mundiais, aumento do sedentarismo e aumento do consumo de gorduras e açúcares, sendo estes vinculados normalmente aos alimentos industrializados. A consequência disso rapidamente se manifestou no aumento do sobrepeso/obesidade e na instalação de alterações fisiológicas e metabólicas, como a Síndrome Metabólica, que é representada por alterações na glicemia, nos lipídeos e na pressão arterial. Há evidências de ligação estreita entre estas alterações e os processos inflamatórios, que também podem estar associados ao estresse oxidativo. Estas condições levam à patogênese das alterações vasculares ou intensificam os processos metabólicos que acompanham a Síndrome Metabólica. O objetivo desta revisão foi comparar as inúmeras referências literárias que mostram correlação entre os componentes da Síndrome Metabólica e o aumento dos mediadores de inflamação. Para isso, utilizou-se Pubmed, Scopus, Lilacs e Scielo como base de dados, sendo que os artigos selecionados dataram principalmente dos últimos cinco anos.Palavras-chave: síndrome metabólica; arteriosclerose; inflamação.

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“…Numerous studies have shown that hsCRP has a positive relationship with body mass index (BMI), overweight/obesity and body adiposity across diverse populations (Ford et al, 2001 in US children; Gildiken et al, 2007 among obese patients; Hodge et al, 2010 in Australian adults; Park et al, 2005 in Korean adults; Rexrode et al, 2003 in US women of age ≥45 years; Silva et al (2010) in Brazilian adolescents). Similarly, hsCRP has been associated with altered blood lipid profiles (Wang et al, 2011 in US overweight university students; Wu et al, 2003 in Taiwanese children) and elevated risk of coronary pathology (Pearson et al, 2003; Ridker et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Nutrient intakes associated with elevated serum C‐reactive protein concentrations in normal to underweight breastfeeding women in Northern Kenya

Fujita

Brindle

et al. 2014

American J Hum Biol

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Objectives Low-grade elevation of C-reactive protein (CRP) is a non-specific inflammatory marker, used as a predictor for cardiovascular disease development and chronic inflammatory risks. Research investigating dietary influences on inflammation has focused primarily on the relationship between dietary characteristics, CRP elevation and BMI in the populations at greatest risk for cardiovascular disease, namely those in the overweight and obese ranges, often in clinical settings and/or among those middle aged or older, leaving little information about normal to underweight populations of reproductive age in ecological settings. This study evaluates impacts of dietary nutrients on serum CRP levels in a population of predominantly underweight to normal weight adult women experiencing the additional nutritional demands of lactation. Methods Data from non-overweight breastfeeding Ariaal women of Kenya collected in 2006 were used (n = 194). Logistic regression models were applied using low-grade CRP elevation (hsCRP > 3 mg/L) as the outcome variable and dietary nutrients, age, BMI, and serum retinol as predictors. Results Models showed that energy intake (Kcal) and age were positive predictors of CRP elevation while folate intake, total vitamin A intake, and serum retinol concentration were protective against CRP elevation. Unlike previous studies among higher BMI populations, this study found no significant effect of dietary lipids/fatty acids or BMI on CRP elevation. Conclusions The effects of specific dietary nutrients on inflammatory status may vary with BMI or, in women, reproductive status. Further research should investigate the role of dietary fats, fatty acids, and antioxidant vitamins across populations with a wide range of BMI, including postpartum women.

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Impacto da proteína-C reativa no risco cardiovascular de adolescentes

Cited by 14 publications

References 26 publications

C-reactive protein and cardiometabolic risk factors in overweight or obese children and adolescents

C-reactive protein and cardiometabolic risk factors in overweight or obese children and adolescents

Síndrome metabólica, aterosclerose e inflamação: tríade indissociável?

Nutrient intakes associated with elevated serum C‐reactive protein concentrations in normal to underweight breastfeeding women in Northern Kenya

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