Síndrome metabólica, aterosclerose e inflamação: tríade indissociável?

Barbalho, Sandra Maria; Bechara, Marcelo Dib; Quesada, Karina; Gabaldi, Márcia Rocha; Goulart, Ricardo de Álvares; Tofano, Ricardo José; Gasparini, Rodrigo Galhardi

doi:10.1590/1677-5449.04315

Cited by 55 publications

(43 citation statements)

References 56 publications

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“…As women attend health services more, they are more likely to be diagnosed and treated for possible morbidities, including MS. In addition, the hormonal changes that occur in menopause make them more susceptible to increased waist circumference and the risk of cardiovascular diseases 1 .…”

Section: Discussionmentioning

confidence: 99%

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Profile of elderly persons with metabolic syndrome and factors associated with possible drug interactions

Tavares

Gomes

Rodriguês

et al. 2018

Rev. bras. geriatr. gerontol.

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Objectives: To describe the sociodemographic, clinical and pharmacotherapy characteristics of elderly persons with metabolic syndrome and to identify factors associated with drug interactions among these individuals. Method: A quantitative, analytical and transversal study was carried out among 263 elderly people with metabolic syndrome in the urban area of Uberaba, Minas Gerais, Brazil. Possible drug interactions were identified and classified according to the Micromedex® DrugReax System. The chi-squared test and the multiple logistic regression model were used for analysis ( p<0.05). Results: The majority of the individuals were female (70.7%); aged 60 to 74 years (72.3%); lived with a spouse/ partner (63.9%); had some schooling (74.1%); an individual monthly income of ≤ one minimum wage (77.1%); lived with others (88.2%); had five or more morbidities (89.7%) and exhibited polypharmacy (73.0%); used potentially inappropriate medications (54.4%) and had possible drug interactions (75.3%). Associated with the possible presence of drug interactions were: age range ( p=0.005), polypharmacy ( p<0.001) and use of potentially inappropriate medications ( p=0.006). Conclusion: Possible drug interactions were associated with increased age, polypharmacy and the use of potentially inappropriate medications. This study contributes to knowledge of these possible interactions among elderly people with metabolic syndrome, and as such can be considered an important tool for planning actions to ensure the safety of these individuals who, due to the complexity of their treatment, use multiple medications.

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Section: Discussionmentioning

confidence: 99%

“…It becomes more prevalent as age increases and among individuals with a determined disease, such as type 2 diabetes mellitus (DM2) and SAH 1 .…”

Section: Introductionmentioning

confidence: 99%

Profile of elderly persons with metabolic syndrome and factors associated with possible drug interactions

Tavares

Gomes

Rodriguês

et al. 2018

Rev. bras. geriatr. gerontol.

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“…Weight gain in climacteric is due to the ageing process and estrogenic depletion, with the centralised distribution of fat mass related to ovarian failure 26 , which leads to a change in the hormonal environment previously dominated by estrogen to an environment where there is a predominance of testosterone, favouring androgenicity 27 . Also, inadequate lifestyle habits, such as sedentary lifestyle, consumption of fats and sugars, can lead to physiological and metabolic alterations 28 . The limited perception of body weight and the importance of the control 29 , and the use of medications such as antidepressants, analgesics, and anxiolytics 30 also compete for the appearance of this condition.…”

Section: Discussionmentioning

confidence: 99%

Health Conditions Associated with Overweight in Climacteric Women

Marques

Freitas

Popoff

et al. 2019

Preprint

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31This study aims to investigate the association between health conditions and 32 overweight in climacteric women assisted by primary care professionals. It is a cross-33 sectional study conducted with 874 women from 40 to 65 years of age, selected by 34 probabilistic sampling between August 2014 and August 2015. In addition to the outcome 35 variable, other variables such as overweight/obesity, sociodemographic, reproductive, 36 clinical, eating and behavioural factors were evaluated. Descriptive analyses of the 37 variables investigated through their frequency distributions were performed. Then, 38 bivariate analyses were performed through Poisson regression. For the multiple analyses, 39 the hierarchical Poisson regression was used to identify factors associated with 40 overweight/obesity in the climacteric period. The prevalence of overweight/obesity was 41 74%. Attending public school (PR: 1.30 -95% CI 1.14 -1.50), low schooling (PR: 1.11 42 -95% CI 1.01 -1.23), gout (PR: 1.18 -95% CI 1.16-1.44), kidney disease (PR: 1.18 -43 95% CI 1.05 -1.32), metabolic syndrome -MS (PR: 1.19 -95% CI 1.05 -1.34) and fat 44 intake (PR: 1.12 -95% CI 1.02 -1.23) were considered risk factors for overweight. 45Having the first birth after 18 years (PR: 0.89 -95% CI 0.82 to 0.97) was shown to be a 46 protective factor for overweight and obesity. The presence of overweight and obesity is 47 associated with socio-demographic, reproductive, clinical and eating habits. 48 49 Introduction 50Brazil has been presenting a rapid process of demographic and epidemiological 51 transition, leading to the frequent occurrence of chronic-degenerative diseases¹. The 52 increase in the prevalence of overweight, represented by overweight and obesity, among 53 the elderly female population raises great concern in developed and developing countries. 3 54Since overweight and obesity are risk factors for adverse health events 2 such as 55 disturbances in lipid and glycidic metabolism, psychological stress and sleep alterations, 56 with increasing risk of cardiovascular diseases 3 , musculoskeletal disease, acute 57 myocardial infarction 4 , cancer 5 and worse quality of life in comparison to those who were 58 satisfied with their body weight 6 . 59Overweight and obesity have become a public health problem in the world. The 60 projection for 2025 is that about 2.3 billion adults are overweight, and more than 700 61 million are obese. According to a study conducted in 2016, the rate of overweight among 62 Brazilian women is 50.5%, increasing this frequency with age and up to 64 years 7 . 63Epidemiological data are still scarce associating excess weight with behavioural 64 and clinical variables in climacteric women 8 , using probabilistic samples 9 . Considering 65 that climacteric is an important period of the women life cycle, and that this period is 66 related to the potential peak of fat mass and obesity in this group, the current study aimed 67 to investigate the association between health conditions and excess of weight ratio in 68 climacteri...

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“…Moreover, there is activation of macrophages and increased synthesis of reactive oxygen species (ROS), consequently increasing the synthesis of CRP and promoting a proinflammatory state, which evolves to insulin-resistance, MS and DM. ( 14 )…”

Section: Action Of Immunoinflammatory Mediatorsmentioning

confidence: 99%

Immunoinflammatory mediators in the pathogenesis of diabetes mellitus

Gomes¹,

Accardo²

2019

Einstein (São Paulo)

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Characterized as a metabolic syndrome with multiple consequences for the lives of patients, diabetes mellitus is also classified as a chronic non-communicable disease of great scope in the world. It is a complex disease, with different points of view, including the relation between inflammatory process, obesity and insulin resistance due to the performance of the various immunoinflammatory mediators - called adipokines - on glycemic homeostasis. Recent studies have precisely addressed this aspect for the development of drugs that assist in the protection of pancreatic ß cells from the damages arising from oxidative stress and inflammatory process, in order to control the hyperglycemic picture, which is characteristic of diabetes mellitus .

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Síndrome metabólica, aterosclerose e inflamação: tríade indissociável?

Cited by 55 publications

References 56 publications

Profile of elderly persons with metabolic syndrome and factors associated with possible drug interactions

Profile of elderly persons with metabolic syndrome and factors associated with possible drug interactions

Health Conditions Associated with Overweight in Climacteric Women

Immunoinflammatory mediators in the pathogenesis of diabetes mellitus

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