Impacts of circadian rhythm and melatonin on the specific activities of immune and antioxidant enzymes of the Chinese mitten crab (Eriocheir sinensis)

She, Qiuxin; Han, Zhibin; Liang, Shudong; Xu, Wei‐Bin; Li, Xin; Zhao, Yingying; Hua, Wei; Dong, Jing; Li, Yingdong

doi:10.1016/j.fsi.2019.04.011

Cited by 30 publications

(14 citation statements)

References 34 publications

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“…This review summarizes the therapeutic potentials of melatonin in the treatment of diabetes mellitus and its complications, based on findings of recent studies. Page 2 of 20 Pourhanifeh et al Diabetol Metab Syndr (2020) 12:30 regulatory role in sleep disorders and reproduction [13,14]. Furthermore, melatonin has immunomodulatory effect [15], which depends on its capability to increase the cytokines production and its anti-apoptotic and antioxidant properties.…”

Section: Introductionmentioning

confidence: 99%

Melatonin: new insights on its therapeutic properties in diabetic complications

Pourhanifeh

Hosseinzadeh

Dehdashtian

et al. 2020

Diabetol Metab Syndr

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Diabetes and diabetic complications are considered as leading causes of both morbidity and mortality in the world. Unfortunately, routine medical treatments used for affected patients possess undesirable side effects, including kidney and liver damages as well as gastrointestinal adverse reactions. Therefore, exploring the novel therapeutic strategies for diabetic patients is a crucial issue. It has been recently shown that melatonin, as main product of the pineal gland, despite its various pharmacological features including anticancer, anti-aging, antioxidant and antiinflammatory effects, exerts anti-diabetic properties through regulating various cellular mechanisms. The aim of the present review is to describe potential roles of melatonin in the treatment of diabetes and its complications.

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Section: Introductionmentioning

confidence: 99%

Melatonin: new insights on its therapeutic properties in diabetic complications

Pourhanifeh

Hosseinzadeh

Dehdashtian

et al. 2020

Diabetol Metab Syndr

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“…The destruction of gill had a serious impact on the crab's respiration and substance exchange, causing them to be unable to grow normally and even caused death (She et al, 2019). The results of gill damage in this experiment were the same as those in Macrobrachium rosenbergii affected by the organochlorine endosulfan (Nonnotte, Boitel, & Trucho, 1993) and the destruction of crustaceans poisoned with the heavy metal copper (Bhavan & Geraldine, 2000; Nonnotte, Boitel, & Trucho, 1993).…”

Section: Discussionmentioning

confidence: 99%

“…LZM, ACP and AKP are enzymes that represented the first lines of defence of the non‐specific immune response of organisms (She et al, 2019). The activity of LSZ can be considered a measure of the immune status of an animal, providing a measure of the pollution levels in an aquaculture environment (Bayne & Gerwick, 2001).…”

Section: Discussionmentioning

confidence: 99%

Hepatopancreatic necrosis disease (HPND) in Chinese mitten crab Eriocheir sinensis tightly linked to low concentration of two insecticides

Shen

Zhang

et al. 2020

Aquaculture Research

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To date, hepatopancreatic necrosis disease (HPND) in Eriocheir sinensis is causing huge financial losses to the aquaculture industry while the cause of HPND remains unclear. Our previous study has implied that HPND is probably relevant to the damages caused by insecticide residues. In this work, the comparative studies regarding histopathology and trends in immune‐related/detoxifying enzymes activities of the crabs were performed between exposed to the low concentration of insecticides (i.e. β‐cypermethrin 8.52 × 10−12 g/L and trichlorfon 5 × 10−5 g/L) in a long‐term (90‐days) and suffered from HPND. The concentration was obtained by a median‐lethal concentration (LC50) and a safe concentration (SC), and it was 10 times lower than the safe concentration in this experiment. This work's principal aim was to investigate the potential chronic effects of low concentrations of insecticides exposure on crabs and their relevance with HPND. As a result, crabs exposed to the low concentration of insecticides caused similar clinical symptoms and severity in hepatopancreas and other tissue damages like HPND. Meanwhile, catalase (CAT), superoxide dismutase (SOD), malondialdehyde (MDA), acid phosphatase (ACP), alkaline phosphatase (AKP), lysozyme (LZM) and carboxylesterase (CarE) enzymatic activity increased after exposure to the two insecticides and then decreased in the later stages, while the activity of glutathione S‐transferase (GSTs) has barely changed. Results of enzymatic activity indicated that the two insecticides induced oxidative damage to the hepatopancreas of E. sinensis. These evidence indicated that the chronic damage caused by the low concentration of insecticides, which is considered insecticide residue, might be part of the causes of HPND in crabs. The present work may enhance our understanding of the pathogenesis of HPND and provide a theoretical basis for the management of intensive crab aquaculture.

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“…as well as antioxidant capacity ( 30 ). The Trp metabolite melatonin, affects the immune system and antioxidant defense system (ADS) of crustaceans ( 33 , 115 ). When eyestalk-ablated E. sinensis were injected with melatonin, both their immune and antioxidant capacity were enhanced in terms of increased THC and hemocyanin levels, coupled with an elevation in the activities of ALP, ACP, superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and other antioxidant enzymes ( 31 ).…”

Section: Amino Acid Metabolism and Crustacean Immunitymentioning

confidence: 99%

Modulation of Crustacean Innate Immune Response by Amino Acids and Their Metabolites: Inferences From Other Species

et al. 2020

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Aquaculture production of crustaceans (mainly shrimp and crabs) has expanded globally, but disease outbreaks and pathogenic infections have hampered production in the last two decades. As invertebrates, crustaceans lack an adaptive immune system and mainly defend and protect themselves using their innate immune system. The immune system derives energy and metabolites from nutrients, with amino acids constituting one such source. A growing number of studies have shown that amino acids and their metabolites are involved in the activation, synthesis, proliferation, and differentiation of immune cells, as well as in the activation of immune related signaling pathways, reduction of inflammatory response and regulation of oxidative stress. Key enzymes in amino acid metabolism have also been implicated in the regulation of the immune system. Here, we reviewed the role played by amino acids and their metabolites in immune-modulation in crustaceans. Information is inferred from mammals and fish where none exists for crustaceans. Research themes are identified and the relevant research gaps highlighted for further studies.

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Impacts of circadian rhythm and melatonin on the specific activities of immune and antioxidant enzymes of the Chinese mitten crab (Eriocheir sinensis)

Cited by 30 publications

References 34 publications

Melatonin: new insights on its therapeutic properties in diabetic complications

Melatonin: new insights on its therapeutic properties in diabetic complications

Hepatopancreatic necrosis disease (HPND) in Chinese mitten crab Eriocheir sinensis tightly linked to low concentration of two insecticides

Modulation of Crustacean Innate Immune Response by Amino Acids and Their Metabolites: Inferences From Other Species

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