Impacts of dietary silver nanoparticles and probiotic administration on the microbiota of an in-vitro gut model

Cattò, Cristina; Garuglieri, Elisa; Borruso, Luigimaria; Erba, Daniela; Casiraghi, Maria Cristina; Cappitelli, Francesca; Villa, Federica; Zecchin, Sarah; Zanchi, R.

doi:10.1016/j.envpol.2018.11.019

Cited by 38 publications

(23 citation statements)

References 119 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In one in vitro study, it was observed that the Ag-NPs modified the Firmicutes/Bacteroidetes phylum ratio, increasing Firmicutes and decreasing Bacteroidetes. It was seen that the nanoparticles altered the intestinal microbiota as would a metabolic and inflammatory disease [100]. On the other hand, after exposure of silver nanoparticles (10 nm) to a concentration range of 0-100 µg/mL, a marked decrease in saturated fatty acids was observed, except in palmitic acid, which increased by 26-32%.…”

Section: Staticmentioning

confidence: 98%

Silver Nanoparticles against Foodborne Bacteria. Effects at Intestinal Level and Health Limitations

et al. 2020

View full text Add to dashboard Cite

Foodborne diseases are one of the factors that endanger the health of consumers, especially in people at risk of exclusion and in developing countries. The continuing search for effective antimicrobials to be used in the food industry has resulted in the emergence of nanotechnology in this area. Silver nanoparticles (Ag-NPs) are the nanomaterial with the best antimicrobial activity and therefore, with great potential of application in food processing and packing. However, possible health effects must be properly addressed to ensure food safety. This review presents a detailed description on the main applications of Ag-NPs as antimicrobial agents for food control, as well as the current legislation concerning these materials. Current knowledge about the impact of the dietary exposure to Ag-NPs in human health with special emphasis on the changes that nanoparticles undergo after passing through the gastrointestinal tract and how they alter the oral and gut microbiota, is also summarized. It is concluded that given their potential and wide properties against foodborne pathogens, research in Ag-NPs is of great interest but is not exempt from difficulties that must be resolved in order to certify the safety of their use.

show abstract

Section: Staticmentioning

confidence: 98%

Silver Nanoparticles against Foodborne Bacteria. Effects at Intestinal Level and Health Limitations

et al. 2020

View full text Add to dashboard Cite

show abstract

“…It is important to note that other methods than sequencing and cultivation exist for assessing microbial composition. For instance, some of the studies analyzed functional aspects like metabolites (e.g., SCFA) and gas production to evaluate the gut microbiome [46,50,54,62].…”

Section: Current Methodological Limitations and Future Directionsmentioning

confidence: 99%

“…Cecal amounts of Firmicutes and Bacteroidetes were unchanged by either form of sliver. In a study using in-vitro batch fermentation models inoculated with human fecal matter, treatment with 1 ug/mL Ag NPs increased the F/B ratio [50]. Ag NPs also induced functional differences in cell motility, translation, transport, and xenobiotics degradation.…”

Section: Ag Npsmentioning

confidence: 99%

“…For instance, if NPs tend to create pro-inflammatory states in the gut, probiotics known to have anti-inflammatory effects may be used as therapeutics. In the study using in-vitro batch fermentation models inoculated with human fecal matter, interactions between 1 ug/mL Ag NPs, the intestinal microbiota, and the probiotic Bacillus subtilis were assessed [50]. The F/B ratio increased with Ag NPs but cocultures with the probiotic had the lowest F/B ratio.…”

Section: Potential Systematic Use Of Probiotics and Nps As Therapeutic Agents Against Gut Dysbiosismentioning

confidence: 99%

See 1 more Smart Citation

Nanoparticles in the Food Industry and Their Impact on Human Gut Microbiome and Diseases

Ghebretatios

Schaly

Prakash

2021

IJMS

View full text Add to dashboard Cite

The use of inorganic nanoparticles (NPs) has expanded into various industries including food manufacturing, agriculture, cosmetics, and construction. This has allowed NPs access to the human gastrointestinal tract, yet little is known about how they may impact human health. As the gut microbiome continues to be increasingly implicated in various diseases of unknown etiology, researchers have begun studying the potentially toxic effects of these NPs on the gut microbiome. Unfortunately, conflicting results have limited researcher’s ability to evaluate the true impact of NPs on the gut microbiome in relation to health. This review focuses on the impact of five inorganic NPs (silver, iron oxide, zinc oxide, titanium dioxide, and silicon dioxide) on the gut microbiome and gastrointestinal tract with consideration for various methodological differences within the literature. This is important as NP-induced changes to the gut could lead to various gut-related diseases. These include irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), celiac disease, and colorectal cancer. Research in this area is necessary as the use of NPs in various industries continues to grow along with the number of people suffering from chronic gastrointestinal diseases.

show abstract

“…It is also used as a probiotic to promote the growth of broiler chicken or shrimp. Several studies have shown that the co-administration of nanoparticles and probiotics has no or few effect on the microbiome composition or activity [49,50]. But chronic oral absorption of nanoparticles, as a consequence of nanoparticles in food additives, disturbs the gut microbiome equilibrium and may be responsible for several chronic diseases [51].…”

Section: Plos Onementioning

confidence: 99%

ZnO and TiO2 nanoparticles alter the ability of Bacillus subtilis to fight against a stress

et al. 2020

View full text Add to dashboard Cite

Due to the physicochemical properties of nanoparticles, the use of nanomaterials increases over time in industrial and medical processes. We herein report the negative impact of nanoparticles, using solid growth conditions mimicking a biofilm, on the ability of Bacillus subtilis to fight against a stress. Bacteria have been exposed to sublethal doses of nanoparticles corresponding to conditions that bacteria may meet in their natural biotopes, the upper layer of soil or the gut microbiome. The analysis of the proteomic data obtained by shotgun mass spectrometry have shown that several metabolic pathways are affected in response to nanoparticles, n-ZnO or n-TiO 2 , or zinc salt: the methyglyoxal and thiol metabolisms, the oxidative stress and the stringent responses. Nanoparticles being embedded in the agar medium, these impacts are the consequence of a physiological adaptation rather than a physical cell injury. Overall, these results show that nanoparticles, by altering bacterial physiology and especially the ability to resist to a stress, may have profound influences on a "good bacteria", Bacillus subtilis, in its natural biotope and moreover, on the global equilibrium of this biotope.

show abstract

Impacts of dietary silver nanoparticles and probiotic administration on the microbiota of an in-vitro gut model

Cited by 38 publications

References 119 publications

Silver Nanoparticles against Foodborne Bacteria. Effects at Intestinal Level and Health Limitations

Silver Nanoparticles against Foodborne Bacteria. Effects at Intestinal Level and Health Limitations

Nanoparticles in the Food Industry and Their Impact on Human Gut Microbiome and Diseases

ZnO and TiO2 nanoparticles alter the ability of Bacillus subtilis to fight against a stress

Contact Info

Product

Resources

About