Impacts of Egyptian propolis extract on rat cerebellum intoxicated by aluminum silicate: histopathological studies

Omar, Nahed; Abu-Almaaty, Ali H.; El-Aziz, Yasmin M. Abd; Abdeen, Ahmed; Mohamed, F.; Hashem, Mohamed; Hammad, Seddik

doi:10.1007/s11356-019-05469-4

Cited by 6 publications

(6 citation statements)

References 33 publications

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“…green propolis [35], Brazilian organic propolis [17], Egyptian propolis [37], Indian propolis [38], Korean propolis [32], Lebanese propolis [33], Nepalese propolis [50], propolis from Turkey [41], and Taiwanese green propolis [24]. Among various propolis, the Brazilian propolis is commonly classified into 13 types based on their properties (mainly: color, chemical composition, texture), and on geographic origin [40,51,52].…”

Section: Plant Animal and Environmental Factors Influencing The Chemi...mentioning

confidence: 99%

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Antifungal Properties of Chemically Defined Propolis from Various Geographical Regions

Ożarowski

Karpiński

Alam³

et al. 2022

Microorganisms

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Long-term fungal infections that are difficult to treat require new substances for their prevention, treatment, or as adjuvants during antibiotic therapy. Propolis is a very promising source of natural substances that show a wide range of pharmacological properties, including antifungal activity against various fungal strains. The purpose of the literature review was to summarize recent studies (PubMed, Scopus) on progress in evaluating the antifungal activity of chemically defined propolis extracts. During the selection of studies, only those with results of antifungal activity expressed as minimal inhibitory concentration (MIC) and/or minimal fungicidal concentration (MFC) were analyzed. Moreover, plant, animal and environmental factors influencing the chemical composition of propolis are discussed. Mechanisms of antifungal activity of propolis extracts and research trends in the aspect of developing new therapies and the assessment of drug interactions are indicated. The review of the research results shows that there is great progress in the definition of propolis extracts. After comparing the MIC/MFC values, it was assessed that propolis extracts offer a wide range of activity not only against pathogenic Candida strains but also against risky molds; however, the strength of this activity is varied.

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Section: Plant Animal and Environmental Factors Influencing The Chemi...mentioning

confidence: 99%

“…Propolis has shown mainly antifungal [8,9,[13][14][15][16][17][18][19][20][21][22], antibacterial [10,19,20,23,24], antiviral [20,[25][26][27][28][29], antiparasitic [5,20,30,31], anti-inflammatory [17,[32][33][34] and neuroprotective activity [35][36][37][38], and also anticancer properties [39][40][41][42].…”

Section: Introductionmentioning

confidence: 99%

Antifungal Properties of Chemically Defined Propolis from Various Geographical Regions

Ożarowski

Karpiński

Alam³

et al. 2022

Microorganisms

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“…Aluminum can impact human organs, tissues and cells, such as the alveolar of pulmonary tissues, renal tissues, hepatocytes, blood, the hippocampus and the cerebrum [14][15][16]. Moreover, chronic or long-term exposure to aluminum silicate leads to the sedimentation of the metal in the lung as well as in other tissues and organs, causing many metabolic disorders, histological damages, membrane changes and alterations to diseases [17][18][19]. Exposure to aluminum can also lead to the production of free radicals in the body.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Property of the Egyptian Propolis Extract Versus Aluminum Silicate Intoxication on a Rat’s Lung: Histopathological Studies

et al. 2020

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In this study, we evaluated the inflammatory responses induced by aluminum silicate (AS) cytotoxicity in rat lungs. The prophylactic effect of propolis extract was evaluated in 60 adult male albino rats. The rats were divided into six groups: (1) a normal, healthy control group; (2) a normal group fed with 200 mL of propolis extract/Kg; (3) a low-dose positive control group injected with 5 mg/kg of AS; (4) a treated group given propolis and a low dose of AS; (5) a high-dose positive control group injected with 20 mg/kg of AS; and (6) a treated group given propolis with a high-dose of AS. At the end of the two-month experiment, the rats’ lungs were removed. For each pair of lungs, one portion was subjected to biochemical analysis and the other underwent hematoxylin and eosin (H&E) staining in order to study its histology. The rats that received AS doses displayed significant disorders in their antioxidant contents as well as in their enzymatic activities and their histopathological structures revealed severe damage to their lung tissues. Upon the rats being treated with propolis, the enzymatic and antioxidant contents improved and partial improvements in the lung structures appeared, including minimized congestion, a reduced hemorrhage of blood vessels and preserved bronchioles, alveolar ducts, and alveoli. The prophylactic effectiveness of propolis extract on the cytotoxicity of AS, owing to the antioxidant properties of propolis, were studied.

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“…In addition, it inhibited apoptosis by reducing the expression of genes associated with apoptosis signaling pathways; protein-coding gene Bax , cytochrome - c , cas - 3 , cas - 8 , and p53 genes [ 24 , 25 ]. It was also evident that propolis protected cell membranes and prevented further deterioration of the tissue morphology associated with toxicity [ 23 , 26 , 28 , 33 , 35 , 37 ].…”

Section: Discussionmentioning

confidence: 99%

Can Propolis Be a Useful Adjuvant in Brain and Neurological Disorders and Injuries? A Systematic Scoping Review of the Latest Experimental Evidence

Zulhendri¹,

Perera

Tandean

2021

Biomedicines

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Propolis has been used therapeutically for centuries. In recent years, research has demonstrated its efficacy as a potential raw material for pharmaceuticals and nutraceuticals. The aim of the present scoping review is to examine the latest experimental evidence regarding the potential use of propolis in protecting the brain and treating neurological disorders and injuries. A systematic scoping review methodology was implemented. Identification of the research themes and knowledge gap was performed. After applying the exclusion criteria, a total of 66 research publications were identified and retrieved from Scopus, Web of Science, Pubmed, and Google Scholar. Several key themes where propolis is potentially useful were subsequently identified, namely detoxification, neuroinflammation, ischemia/ischemia-reperfusion injury/traumatic brain injury, Alzheimer’s disease, Parkinson’s disease, and epilepsy models, depression, cytotoxicity, cognitive improvement, regenerative medicine, brain infection, and adverse effects. In conclusion, propolis is shown to have protective and therapeutic benefits in alleviating symptoms of brain and neurological disorders and injuries, demonstrated by various in vitro studies, animal models, and human clinical trials. Further clinical research into this area is needed.

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Impacts of Egyptian propolis extract on rat cerebellum intoxicated by aluminum silicate: histopathological studies

Cited by 6 publications

References 33 publications

Antifungal Properties of Chemically Defined Propolis from Various Geographical Regions

Antifungal Properties of Chemically Defined Propolis from Various Geographical Regions

Antioxidant Property of the Egyptian Propolis Extract Versus Aluminum Silicate Intoxication on a Rat’s Lung: Histopathological Studies

Can Propolis Be a Useful Adjuvant in Brain and Neurological Disorders and Injuries? A Systematic Scoping Review of the Latest Experimental Evidence

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