Impacts of Hyper-Homocysteinemia and White Matter Hyper-Intensity in Alzheimers Disease Patients with Normal Creatinine: An MRI-Based Study with Longitudinal Follow-up

Huang, Chi‐Wei; Chang, Wen-Neng; Lui, Chun‐Chung; Chen, C. F.; Lu, Cheng-Hsien; Wang, Y. L.; Chen, C.; Juang, Yeong‐Yuh; Lin, Yu-Ting; Tu, Manghui; Chang, Chiung‐Chih

doi:10.2174/156720510792231702

Cited by 31 publications

(32 citation statements)

References 43 publications

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“…Although not consistently reported (e.g. (Huang et al, 2010), studies have found that homocysteine levels in AD can predict rates of cognitive decline (Huang et al, 2013;Oulhaj et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Homocysteine concentrations in the cognitive progression of Alzheimer's disease

Farina

Jernerén

Turner

et al. 2017

Experimental Gerontology

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Section: Introductionmentioning

confidence: 99%

Homocysteine concentrations in the cognitive progression of Alzheimer's disease

Farina

Jernerén

Turner

et al. 2017

Experimental Gerontology

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“…Both deep and periventricular white matter hyperintensities (WMHs) have been reported to be significantly associated with AD degeneration process in both cross-sectional and longitudinal studies [17–19]. The presence of WMHs in AD may reflect multiple physiological and pathological changes such as breakdown of the blood-brain barrier [20], impaired cerebral auto-regulation [21], vasculopathies, and inflammation [22, 23].…”

Section: Introductionmentioning

confidence: 99%

Genetic effect of interleukin-1 beta (C-511T) polymorphism on the structural covariance network and white matter integrity in Alzheimer’s disease

Huang

Hsu

Tsai

et al. 2017

J Neuroinflammation

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BackgroundInflammatory processes play a pivotal role in the degenerative process of Alzheimer’s disease. In humans, a biallelic (C/T) polymorphism in the promoter region (position-511) (rs16944) of the interleukin-1 beta gene has been significantly associated with differences in the secretory capacity of interleukin-1 beta. In this study, we investigated whether this functional polymorphism mediates the brain networks in patients with Alzheimer’s disease.MethodsWe enrolled a total of 135 patients with Alzheimer’s disease (65 males, 70 females), and investigated their gray matter structural covariance networks using 3D T1 magnetic resonance imaging and their white matter macro-structural integrities using fractional anisotropy. The patients were classified into two genotype groups: C-carriers (n = 108) and TT-carriers (n = 27), and the structural covariance networks were constructed using seed-based analysis focusing on the default mode network medial temporal or dorsal medial subsystem, salience network and executive control network. Neurobehavioral scores were used as the major outcome factors for clinical correlations.ResultsThere were no differences between the two genotype groups in the cognitive test scores, seed, or peak cluster volumes and white matter fractional anisotropy. The covariance strength showing C-carriers > TT-carriers was the entorhinal-cingulum axis. There were two peak clusters (Brodmann 6 and 10) in the salience network and four peak clusters (superior prefrontal, precentral, fusiform, and temporal) in the executive control network that showed C-carriers < TT-carriers in covariance strength. The salience network and executive control network peak clusters in the TT group and the default mode network peak clusters in the C-carriers strongly predicted the cognitive test scores.ConclusionsInterleukin-1 beta C-511 T polymorphism modulates the structural covariance strength on the anterior brain network and entorhinal-interconnected network which were independent of the white matter tract integrity. Depending on the specific C-511 T genotype, different network clusters could predict the cognitive tests.Electronic supplementary materialThe online version of this article (doi:10.1186/s12974-017-0791-z) contains supplementary material, which is available to authorized users.

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“…29 Hyperglycemia, increased food intake, and reduced body weight were observed in the test animals. 36 Dioscorea opposita-treated rats with STZ-induced diabetes displayed increased sensitivity to exogenous insulin. These pre-DM conditions observed in the test animals were similar to those in patients with normal insulin levels but poor diabetic responses (i.e., insulin resistance).…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory and hypoglycemic efficacy of Poria cocos and Dioscorea opposita in prediabetes mellitus rats

et al. 2014

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Poria cocos (Fu Ling) and Dioscorea opposita (Chinese Yam) were suggested to have potential benefits in blood sugar control. However, little is known about the underlying mechanisms. In this study, we investigated the anti-inflammatory and hypoglycemic effects of Poria cocos and Dioscorea opposita extracts in prediabetic rats. Fifty streptozotocin-injected rats with a mimic prediabetic status were gavaged with a single dose of either D. opposita (0.35 g kg À1 per day) or P. cocos (0.14 g kg À1 per day), a combination dose comprising single doses of the 2 herbal extracts, or vehicle for a 6-week treatment.Each group contained 10 rats. Blood and selected organ samples were collected during the study. The results indicated that administering the extracts singly or in combination for 6 week, significantly reduced the fasting blood-glucose level. The levels of interleukin-6 in plasma and selected organs significantly decreased during the treatment. The concentration of plasma free fatty acids (FFA) and the ratio of n À 6/n À 3 polyunsaturated fatty acids (PUFAs) were also significantly lowered after the 6 week intervention. The results indicate that administering P. cocos and D. opposita extracts produced anti-inflammatory effects in prediabetic rats by reducing the levels of interleukin-6 and the FFA ratio of n À 6/n À 3 PUFAs.

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Impacts of Hyper-Homocysteinemia and White Matter Hyper-Intensity in Alzheimers Disease Patients with Normal Creatinine: An MRI-Based Study with Longitudinal Follow-up

Cited by 31 publications

References 43 publications

Homocysteine concentrations in the cognitive progression of Alzheimer's disease

Homocysteine concentrations in the cognitive progression of Alzheimer's disease

Genetic effect of interleukin-1 beta (C-511T) polymorphism on the structural covariance network and white matter integrity in Alzheimer’s disease

Anti-inflammatory and hypoglycemic efficacy of Poria cocos and Dioscorea opposita in prediabetes mellitus rats

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