Impacts of pathogen-host-drug interaction in the evolution and spread of antimicrobial-resistant pathogens

Abstract

BackgroundAntibiotic drugs are unquestionably the most effective form of chemotherapy and have a significant impact on the survival of bacteria. However, microbes have an amazing ability to adapt to these antibiotic drugs. The rapid emergency and evolution of antimicrobial resistant strains of pathogenic bacteria have a serious health risks since the earliest days of antibiotic research because bacteria have an evolved mechanism to overcome the effect of antibiotics and thereby become resistant, which is depending on species type and geographical location [1]. Even though, a

Unraveling resistance mechanisms in combination therapy: A comprehensive review of recent advances and future directions

“…Host-pathogen interactions and microbial ecology: Investigating the impact of host-pathogen interactions and the broader microbial ecology on AMR development will offer a more comprehensive understanding of the factors influencing resistance in bacteria treated with combination strategies. This knowledge will inform the development of targeted therapies that consider the complex interplay between bacteria, the host, and their environment [ 91 , 104 , 105 ].…”