“…Many chemicals added directly and indirectly to natural systems by human activities can be taken up by organisms and then transferred through the food chain, accumulating in tissues of organisms at higher trophic levels, including humans, and impacting their physiology [35]. Substances of concern include those that have long been recognized, such as heavy metals (mercury, aluminum, copper, iron, lead, arsenic, and zinc), as well as emerging toxicants such as pharmaceuticals (e.g., pain relievers, blood pressure modulators, cholesterol reducers, antidepressants, contraceptives, and antibiotics) and active ingredients in personal care products (e.g., detergents, perfumes, and sunscreens) [86]. These contaminants mainly enter the environment via municipal effluent discharges, particularly poorly treated sewage, with other sources including aquaculture, animal husbandry, and horticulture runoff and waste disposal [87].…”