Soil degradation due to global warming, water scarcity and diminishing natural resources negatively impacts food security. Soil fertility deterioration, particularly phosphorus (P) deficiency, remains a challenge in the arid and semi-arid regions. In this study, field experiments were conducted in different geographical locations to investigate the effects of organic amendments coupled with P fertilization and irrigation on soil physical-chemical properties, and the growth, yield and quality of wheat. Application of P fertilizers combined with organic amendments mitigated soil salinity, increased organic matter content, available water, hydraulic conductivity and available macronutrients, but decreased soil bulk density. Application of organic amendments slightly increased total Cd, Ni and Pb in soil, but Cd and Ni concentration was below allowable limits whilst Pb reached a hazardous level. Soil P fractions were significantly increased with the combined application of mineral P and organic amendments irrespective of salinity and irrigation. Crop growth yield and quality of wheat improved significantly in response to the integrated application of mineral P and organic amendments. In conclusion, the combination of mineral P sources with organic amendments could be successfully used as a costeffective management practice to enhance soil fertility and crop production in the arid and semi-arid regions stressed with water scarcity and natural resource constraints. Saline soils are an important natural resource but the area of degraded saline soils worldwide has rapidly increased due to climate change and limited rainfall, which poses a great challenge to global food security 1,2. This problem may be solved through a targeted remediation program of such soils. Deficit irrigation (DI) is also projected to increase soil salinity and sodicity, particularly in the arid and semi-arid climatic regions 3 , requiring proper management strategies to alleviate soil degradation. Contamination of soils with heavy metals has become a global concern, due to potential hazardous impacts of these elements on soil quality, crop yield and quality 4 , and food safety and human health 5. Application of organic amendments was reported to remediate saline soils, alleviate salinity and sodicity stress on crops 6 , and reduce toxicity of heavy metals 4. Some organic amendments contain heavy metals, and their application benefits require further studies 7. Organic amendments could improve soil properties by accelerating leaching of sodium and other salts and reducing exchangeable sodium percentage (ESP) 8. Moreover, organic amendments enhance soil biological and enzyme activities and increase organism