Precipitation plays an important role in permafrost hydrology; it can alter the hydrothermal condition of the active layer and even influence the permafrost aggradation or degradation. Moisture recycling from evaporation and transpiration can greatly contribute to local precipitation in some regions. This study selected four monitoring sites and used an isotope mixing model to investigate local moisture recycling in permafrost regions of the central Qinghai-Tibet Plateau (QTP). The results showed that the local water vapour flux in the summer and autumn were dominantly influenced by westerlies and the Indian monsoon. Moistures for precipitation in Wudaoliang (WDL) and Fenghuoshan (FHS) mainly came from the western QTP, eastern Tianshan Mountains, western Qilian Mountains, and the surrounding regions. In comparsion, more than half of precipitation at Tanggula (TGL) was mostly sourced from the Indian monsoon. Local moisture recycling ratios at the four sites ranged from 14% ± 3.8% to 31.6% ± 4.8%, and depended on the soil moisture and relative humidity. In particular, the higher soil moisture and relative humidity promoted local moisture recycling, but frozen ground might be a potential influencing factor as well. The moisture recycling ratios of the study area were consistent with the results from both the Qinghai Lake Basin and the Nam Co Basin, but differed from those of the northwestern QTP. This difference may indirectly confirm the great spatial variability in precipitation on the QTP. Moreover, the rising air temperature and ground temperature, increasing precipitation, higher soil moisture, higher vegetation cover, and expanding lakes in the study area may be conductive to enhancing future local moisture recycling by altering ground surface conditions and facilitating the land surface evaporation and plant transpiration.